{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:09:44Z","timestamp":1786982984624,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Mereo BioPharma, Shriners Hospitals for Children"},{"name":"FRQS Programme de bourses de chercheur"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Osteogenesis imperfecta (OI) is characterized by bone fragility with frequent fractures, especially in children. Some studies have used peripheral-QCT (pQCT) to examine bone density in children with OI and one cross-sectional study used HR-pQCT in 9 children with OI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We compared bone density, microstructure, and strength changes over 1\u00a0yr at the metaphysis and diaphysis of the radius and tibia, as well as lumbar spine (LS) bone mass and area, in 20 children with OI under bisphosphonate treatment and 20 age- and sex-matched controls. For the double-stack metaphyseal scans, we developed an algorithm to correct stack misalignment. For the LS, we used DXA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the tibial metaphysis, children with OI had lower baseline total and trabecular volumetric BMD (vBMD), trabecular and cortical microstructure, and strength. At the radial metaphysis, baseline trabecular microstructure and strength were lower in children with OI. At the tibial and radial diaphysis, children with OI had lower bone area and strength. At the tibial and radial metaphysis, 1-yr increases in most measurements were similar for both groups. Cortical vBMD and trabecular separation (radius) only increased in the OI group. Trabecular vBMD, volume fraction (tibia), number (tibia), and total vBMD (radius) only increased in the control group. At the tibia and radius diaphysis, cortical vBMD increased in the OI group. Tibial Ct.Po decreased in children with OI. At the LS, the OI group had lower bone mass, density, and area, but similar longitudinal changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>In summary, baseline trabecular bone density, trabecular and cortical microstructure, and strength were lower in metaphyseal regions of children with OI. At diaphysis, children with OI had lower bone area and strength. While longitudinal changes over 1\u00a0yr were generally comparable, certain outcomes demonstrated differences. These data are essential for powering future clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jbmr\/zjaf112","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:54:07Z","timestamp":1758196447000},"page":"638-650","source":"Crossref","is-referenced-by-count":1,"title":["Bone microstructural and strength changes over 1\u00a0year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-976X","authenticated-orcid":false,"given":"Seyedmahdi","family":"Hosseinitabatabaei","sequence":"first","affiliation":[{"name":"Research Centre, Shriners Hospitals for Children-Canada , Montreal, QC H4A 0A9,","place":["Canada"]},{"name":"Department of Biomedical Engineering, McGill University , Montreal, QC H3A 2B4 ,","place":["Canada"]},{"name":"Faculty of Dental Medicine and Oral Health Sciences, McGill 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,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-3372","authenticated-orcid":false,"given":"Elizabeth A","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Research Centre, Shriners Hospitals for Children-Canada , Montreal, QC H4A 0A9,","place":["Canada"]},{"name":"Faculty of Dental Medicine and Oral Health Sciences, McGill University , Montreal, QC H3A 1G1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6616-3484","authenticated-orcid":false,"given":"Francis H","family":"Glorieux","sequence":"additional","affiliation":[{"name":"Research Centre, Shriners Hospitals for Children-Canada , Montreal, QC H4A 0A9,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrick","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"Research Centre, Shriners Hospitals for Children-Canada , 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