{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:06:13Z","timestamp":1789200373471,"version":"build-2803163510"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Impact and resistance exercise have potent osteogenic effects and may positively affect cartilage through tissue deformation. These effects may be mediated through inhibitors of Wnt signaling, such as sclerostin and Dickkopf WNT signaling pathway inhibitor 1 (DKK1), which may also play a role in cartilage metabolism. This study evaluated the effect of acute bouts of impact and resistance exercise on biomarkers of bone turnover, signaling, and cartilage metabolism. Healthy young men completed impact or resistance exercise and a control trial in random order. Impact exercise involved 120 maximum-effort multidirectional jumps and hops. Resistance exercise involved 120 high load lower limb lifts. Jumps and lifts were interspersed with 1-3\u00a0s pauses. In control trial, participants rested in a supine position for same duration as exercise trial. Blood samples were taken before, immediately, and 24\u00a0h post-exercise\/rest and analyzed for sclerostin, DKK1, C-terminal telopeptide of type I collagen (CTX-I), procollagen I N-terminal propeptide (PINP), procollagen II C-terminal propeptide (PIICP), and cartilage oligomeric matrix protein. Repeated measures ANOVA compared time points, trials, and their interaction. Participants were 26 men, mean (SD) age 23.4 (2.9) yr. Impact exercise increased PINP immediately post-exercise (by mean [95% CI] + 10.8[4.8, 17.2]%, p\u2009=\u2009.002) and 24\u00a0h later (+7.4 [0.0, 15.3]%, p\u2009=\u2009.05), whereas resistance exercise had no effect. A transient increase in sclerostin immediately post-exercise occurred in the impact exercise trial only (+36.3 [24.6, 49.3]%, p\u00a0&amp;lt;\u2009.001). Both exercise modes transiently increased DKK1 immediately post-exercise (impact +32.4 [23.1, 42.4]%, p\u00a0&amp;lt;\u2009.001; resistance +30.3 [22.8, 38.4]%, p\u00a0&amp;lt;\u2009.001). Cartilage oligomeric matrix protein increased immediately after resistance exercise only (+36.2 [16.0, 59.8]%, p\u00a0&amp;lt;\u2009.001). Neither form of exercise affected CTX-I. Impact and resistance exercise transiently increased Wnt signaling inhibitors. Resistance exercise increased a marker of cartilage turnover but did not affect markers of bone turnover. Impact exercise did not affect cartilage turnover markers. Increases in bone formation but not resorption markers may reflect positive adaptation to impact loading.<\/jats:p>","DOI":"10.1093\/jbmr\/zjaf128","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:53:28Z","timestamp":1758196408000},"page":"282-292","source":"Crossref","is-referenced-by-count":3,"title":["Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8052-8742","authenticated-orcid":false,"given":"Benjamin","family":"Boxer","sequence":"first","affiliation":[{"name":"National Centre of Sports and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University , Loughborough, LE11 3TU ,","place":["United Kingdom"]},{"name":"The Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Loughborough University , Loughborough, LE11 3TU ,","place":["United 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Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University , Loughborough, LE11 3TU ,","place":["United Kingdom"]},{"name":"The Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Loughborough University , Loughborough, LE11 3TU ,","place":["United Kingdom"]},{"name":"Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Afyonkarahisar Health Sciences University , D\u00f6rtyol Neighborhood, 2078 Street, Afyonkarahisar, 03030 ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Brooke-Wavell","sequence":"additional","affiliation":[{"name":"National Centre of Sports and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University , Loughborough, LE11 3TU ,","place":["United Kingdom"]},{"name":"National Institute for Health and Care Research (NIHR) Leicester Biomedical Research Centre ,","place":["United 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