{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:24:05Z","timestamp":1786955045998,"version":"build-2736575974"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,26]]},"abstract":"<jats:title>Vignette<\/jats:title>\n                  <jats:p>A 38-yr-old primigravida presented at 30\u2009+\u20092 wk gestation with pregnancy-induced hypertension and was found to have severe hypercalcemia (adjusted calcium 3.19\u00a0mmol\/L). Intravenous fluid therapy produced only transient improvement, and recurrent hypercalcemia required repeated inpatient management. PTH was suppressed, while both 25(OH)D\u2083 and 1,25(OH)\u2082D\u2083 (calcitriol) were elevated. Imaging and laboratory investigations revealed no evidence of malignancy or granulomatous disease. Delivery by elective cesarean section was undertaken at 35 wk gestation. The neonate developed transient hypocalcemia with suppressed PTH, requiring brief i.v. calcium supplementation. Maternal hypercalcemia persisted postpartum, and renal imaging revealed nephrolithiasis and nephrocalcinosis. Serum calcium remained elevated during lactation but normalized after weaning. Extended vitamin D metabolite profiling showed an increased 25(OH)D\u2083:24,25(OH)\u2082D\u2083 ratio, and genetic analysis confirmed compound heterozygous pathogenic variants in CYP24A1, encoding vitamin D 24-hydroxylase, the enzyme responsible for calcitriol degradation. The findings established a diagnosis of gestational hypercalcemia due to CYP24A1 deficiency. Normal pregnancy is associated with physiological rises in calcitriol, reduced PTH, and hypercalciuria, features that can mimic or mask this disorder. This case illustrates the diagnostic challenges of recognizing CYP24A1 deficiency in pregnancy.<\/jats:p>","DOI":"10.1093\/jbmr\/zjaf203","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:40:25Z","timestamp":1767789625000},"page":"492-496","source":"Crossref","is-referenced-by-count":0,"title":["Challenges and pitfalls in diagnosing and managing severe gestational hypercalcemia"],"prefix":"10.1093","volume":"41","author":[{"given":"Charlotte","family":"Dewdney","sequence":"first","affiliation":[{"name":"Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh , Edinburgh EH16 4SA ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Penswick","sequence":"additional","affiliation":[{"name":"Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh , Edinburgh EH16 4SA ,","place":["United 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