{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T08:16:03Z","timestamp":1787991363785,"version":"build-2784847793"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Augustinus Foundation"},{"name":"FWO scientific research network","award":["W000321N"],"award-info":[{"award-number":["W000321N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 2 diabetes mellitus (T2DM) is common in patients with chronic kidney disease (CKD). Both conditions are associated with an increased fracture risk, with the proposed etiology including impaired bone quantity and quality. This cross-sectional study examined the bone phenotype in patients with T2DM and kidney failure and explored the role of glycemic control on the bone phenotype. To do so, laboratory parameters of mineral metabolism (including sclerostin) and bone turnover markers (BTM) (bone-specific alkaline phosphatase [BALP], trimeric pro-collagen type I N-terminal propeptide [intact P1NP], and tartrate-resistant acid phosphatase isoform 5b [TRACP5b]) were assessed in 647 patients with kidney failure, of which 102 had T2DM (median hemoglobin A1c [HbA1c] of 6.2%), at the time of kidney transplantation. Patients with type 1 DM were excluded. BMD (n\u2009=\u2009555) by densitometry, and bone histomorphometry (n\u2009=\u2009188) were available for subsets, and correlations between HbA1c and both BTM and BMD were examined. This study found that intact P1NP was lower (68 vs 82\u00a0\u03bcg\/L, p\u2009=\u2009.03) while sclerostin was higher (2.1 vs 1.8\u00a0ng\/mL, p\u2009=\u2009.04) in T2DM versus non-T2DM in an unadjusted analysis. BMD at the lumbar spine (Z-score: \u22120.066 vs \u22120.760, p\u2009&amp;lt;\u2009.001) and femoral neck (Z-score: \u22120.680 vs \u22120.965, p\u2009=\u2009.04) were higher in T2DM, and T2DM was in multivariable regression analysis identified as a significant determinant of lumbar spine BMD, independent of age, sex, and BMI. Bone histomorphometric parameters did not differ between groups. A correlation between HbA1c and BTM and BMD was present, but only in non-T2DM (BALP [\u03c1\u2009=\u2009\u22120.12, p\u2009=\u2009.007], intact P1NP [\u03c1\u2009=\u20090.14, p\u2009=\u2009.002], TRACP5b [\u03c1\u2009=\u2009\u22120.13, p\u2009=\u2009.003], BMD at the lumbar spine [\u03c1\u2009=\u20090.12, p\u2009=\u2009.008], femoral neck [\u03c1\u2009=\u20090.11, p\u2009=\u2009.02], and total hip [\u03c1\u2009=\u20090.17, p\u2009&amp;lt;\u2009.001]). In conclusion, patients with kidney failure and T2DM have preserved BMD compared with patients without diabetes. Our findings suggest a role for hyperglycemia as a determinant of the bone phenotype.<\/jats:p>","DOI":"10.1093\/jbmr\/zjag019","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:37:55Z","timestamp":1769603875000},"page":"988-997","source":"Crossref","is-referenced-by-count":1,"title":["Bone phenotype in patients with kidney failure with and without type 2 diabetes"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6695-7513","authenticated-orcid":false,"given":"Sabina Chaudhary","family":"Hauge","sequence":"first","affiliation":[{"name":"Department of Nephrology, Copenhagen University Hospital \u2013 Herlev and Gentofte , 2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-2615","authenticated-orcid":false,"given":"Hanne Skou","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Aalborg University Hospital , 9000 Aalborg ,","place":["Denmark"]},{"name":"Institute of Clinical Medicine, Aarhus University ,","place":["8200 Aarhus N, Denmark"]},{"name":"Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group , KU Leuven, 3000 Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Claes","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group , KU Leuven, 3000 Leuven ,","place":["Belgium"]},{"name":"Department of Medicine, Division of Nephrology, University Hospital Leuven , 3000 Leuven ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-443X","authenticated-orcid":false,"given":"Anja","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Department of Biomedical 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