{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:21:59Z","timestamp":1789525319917,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>People with HIV (PLWH) are living longer with antiretroviral therapy (ART) but HIV increases the risk of age-associated diseases including osteoporosis. A cross-sectional study of men and women \u226540 years was conducted in Harare, Zimbabwe. Sociodemographic data, HIV status\/treatment, and anthropometry were collected. Outcomes were peripheral quantitative computed tomography (pQCT): total volumetric bone mineral density v(BMD), trabecular vBMD, cross-sectional area (CSA), compressive bone strength (BSIc), cortical vBMD, cortical thickness, proximal CSA, and polar stress-strain index (pSSI). Sex-stratified linear regression determined differences by HIV status, minimally adjusted for age and wealth-index (WI), and further adjusted for height and weight. Linear regression adjusted for age and WI assessed associations between HIV- and ART-duration, TDF-use, and viral suppression on bone. 1101 participants (PLWH 20.3%; Male 48.6%), aged mean(SD) 62.4(14.1) years, had pQCT data. HIV-related bone impairments, robust to full adjustment for age, wealth-index, height, and weight were observed. Men with HIV (MLWH) had lower radial total vBMD (-7.1% [-10.9; -3.2]%), trabecular vBMD (-11.3% [-16.9%; -5.6%]), and BSIc (-12.0% [-18.7%; -5.4]%) than HIV-negative men. Trabecular findings were similar in women with HIV (WLWH), plus lower cortical vBMD (-1.4 [-2.3; -0.6]%) and thickness (-7.2 [-11.1; -3.3]% were also seen. Tibial pQCT findings were broadly consistent. In WLWH , years since HIV-diagnosis were associated with lower radius total vBMD (-1.9% per-year [-3.2%; -0.6%]), trabecular vBMD (-4.2% [-6.5%; -2.0%]), BSIc (-3.9% [-6.2%; -1.6%]), cortical vBMD (-0.3% [-0.6%; -0.1%]), and thickness (-1.6% [-2.7%; -0.5%]). In MLWH, years since HIV-diagnosis were associated with smaller proximal tibia CSA (-1.0% [-1.9%; -0.2%]) and TDF-use with lower tibia cortical vBMD (-1.4% [-2.8%; -0.1%]). Older Zimbabwean PLWH have markedly lower trabecular vBMD compared to HIV-negative peers additional cortical compartment impairments were evident in women. These data add to the growing evidence that women with HIV in particular may be at increased risk of age-associated osteoporotic fragility fracture relatively early in their life-course.<\/jats:p>","DOI":"10.1093\/jbmr\/zjag082","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T11:42:32Z","timestamp":1778240552000},"page":"848-858","source":"Crossref","is-referenced-by-count":2,"title":["Sex-specific bone architectural deficits among older adults living with HIV: a cross-sectional study from Zimbabwe"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9695-6378","authenticated-orcid":false,"given":"M\u00edche\u00e1l","family":"\u00d3 Breasail","sequence":"first","affiliation":[{"name":"Department of Medicine, School of Clinical Sciences, Faculty of Medicine, Monash Medical Centre, Nursing and Health Sciences, Monash University , Clayton, VIC ,","place":["Australia"]},{"name":"Global Musculoskeletal Research Group, 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