{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:14:35Z","timestamp":1783527275873,"version":"3.55.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019783","name":"National Agency for Research and Development","doi-asserted-by":"crossref","award":["DOCTORADO BECAS CHILE\/2019-72200405"],"award-info":[{"award-number":["DOCTORADO BECAS CHILE\/2019-72200405"]}],"id":[{"id":"10.13039\/100019783","id-type":"DOI","asserted-by":"crossref"}]},{"name":"EUR IMCBio","award":["ANR-17-EURE-0023"],"award-info":[{"award-number":["ANR-17-EURE-0023"]}]},{"name":"SFRI-STRAT\u2019US project","award":["ANR 20-SFRI-0012"],"award-info":[{"award-number":["ANR 20-SFRI-0012"]}]},{"name":"IdEx Unistra","award":["ANR-10-IDEX-0002"],"award-info":[{"award-number":["ANR-10-IDEX-0002"]}]},{"name":"Interdisciplinary Thematic Institute IMCBio"},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE17-0009"],"award-info":[{"award-number":["ANR-21-CE17-0009"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Ministry of Health","award":["PHRC 2008N\u00b04266"],"award-info":[{"award-number":["PHRC 2008N\u00b04266"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Teeth are established as targets for vitamin D metabolites but have retained less attention than the well-defined bone cell metabolism. Here, we report that VDRgem mice, which bear a point-mutated vitamin D receptor (VDR) unresponsive to the endogenous bioactive vitamin D, are more severely affected and have a greater severity of tooth and alveolar bone defects than VDR-null mice. Transcriptional profiling of postnatal day 5 VDRgem and VDR-null mutant incisors revealed vitamin D ligand signaling targets that promote mineralization, induce alveolar bone growth, and assure dentin integrity. RNA-sequencing analysis of VDRgem mutants uniquely showed defects in developmental targets\u2014notably Hedgehog and Wnt signaling reductions. Micro-CT (\u03bcCT) and microscopy analysis of adult VDRgem mice unravels severely reduced alveolar bone density, with abnormal root and pulp morphology. VDRgem mutants have severely hypocalcified alveolar bone and dentin\u2014comparatively worse than VDR-null mice\u2014as confirmed by SEM and mineral analysis. This genetically confirmed that vitamin D, acting through its receptor, enables bone and tooth to accumulate enough calcium and phosphorous for structural integrity. In addition, enamel structure is defective in VDRgem mice, displaying hypomineralized areas. Collectively, the severe defects in VDRgem tooth and alveolar bone demonstrate the importance of vitamin D actions at early stages of tooth development.<\/jats:p>","DOI":"10.1093\/jbmr\/zjag093","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:49:54Z","timestamp":1780487394000},"source":"Crossref","is-referenced-by-count":0,"title":["Impaired vitamin D signaling reveals novel targets in tooth and alveolar bone"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3967-3996","authenticated-orcid":false,"given":"Alexandra","family":"Jimenez-Armijo","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U1258, CNRS-UMR7104, Universit\u00e9 de Strasbourg , Illkirch-Graffenstaden, 67404 ,","place":["France"]},{"name":"Centre de r\u00e9f\u00e9rence des maladies rares orales et dentaires, CRMR O-Rares, Fili\u00e8re Sant\u00e9 Maladies rares TETECOU, European Reference Network ERN CRANIO, H\u00f4pitaux Universitaires de Strasbourg (HUS), P\u00f4le de M\u00e9decine et Chirurgie Bucco-dentaires, H\u00f4pital Civil , Strasbourg, 67091 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naji","family":"Kharouf","sequence":"additional","affiliation":[{"name":"Laboratoire de Biomat\u00e9riaux et Bioing\u00e9nierie, INSERM UMR_S 1121, Universit\u00e9 de Strasbourg , Strasbourg, 67000 ,","place":["France"]},{"name":"Facult\u00e9 de Chirurgie Dentaire-Robert Frank, Universit\u00e9 de Strasbourg , Strasbourg, 67000 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supawich","family":"Morkmued","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U1258, CNRS-UMR7104, Universit\u00e9 de Strasbourg , Illkirch-Graffenstaden, 67404 ,","place":["France"]},{"name":"Pediatrics Division, 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Inserm AP-HP , Paris, 75006 ,","place":["France"]},{"name":"Centre de Recherche des Cordeliers, Universit\u00e9 Paris Cit\u00e9, Sorbonne Universit\u00e9, INSERM U1138, Molecular Oral Physiopathology , Paris, 75006 ,","place":["France"]},{"name":"Department of Oral Biology, Dental Faculty, Universit\u00e9 Paris Cit\u00e9 , Paris, 75006 ,","place":["France"]},{"name":"Centre de r\u00e9f\u00e9rence des maladies rares orales et dentaires, CRMR O-Rares, Fili\u00e8re Sant\u00e9 Maladies rares TETECOU, European Reference Network ERN CRANIO, H\u00f4pital Rothschild, AP-HP , Paris, 75012 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Laverny","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), INSERM U1258, CNRS-UMR7104, Universit\u00e9 de Strasbourg , Illkirch-Graffenstaden, 67404 ,","place":["France"]},{"name":"OSCAR, French Network for Rare Bone 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