{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:56:16Z","timestamp":1790898976079,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Central giant cell granuloma (CGCG) is a rare lesion of the maxilla and\/or mandible affecting young adults. Traditionally, first-line management includes surgery, however surgery portends significant associated risks, including risk of disfigurement, especially given the young age of patients affected and the facial placement of the lesion. Medical therapy has been previously described; however, there is uncertainty regarding choice, duration of medical therapy, and risk of recurrence. RANKL inhibition through denosumab has previously been described in a related condition, giant cell tumor of bone, and has been used in CGCG in other small case series. Here, we propose the usage of denosumab as a neo-adjuvant treatment prior to surgical resection. We describe a denosumab regimen of 120\u00a0mg monthly s.c. with a stepwise increase in dosing interval depending on individual clinical, biochemical, and radiological response to treatment, to 2-monthly, 3-monthly, and 6-monthly. Twelve patients were included in this longitudinal study, and clinical and radiologic response was seen in all patients after a mean of 3 and 6 denosumab doses, respectively. Neoadjuvant denosumab use led to complete remission in the majority of cases. Adverse events included hypocalcemia and hypercalcemia, with no cases of medication related osteonecrosis of the jaw. This study demonstrates efficacy of denosumab in the treatment of CGCG both as initial and final treatment and as neo-adjuvant treatment prior to surgical resection.<\/jats:p>","DOI":"10.1093\/jbmr\/zjag097","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:19:13Z","timestamp":1781612353000},"source":"Crossref","is-referenced-by-count":1,"title":["Central giant cell granuloma: a decade of institutional experience and curative potential of neoadjuvant denosumab"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1656-4305","authenticated-orcid":false,"given":"Chih Ying","family":"Ko","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology, Westmead Hospital , Sydney, NSW 2145 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedley","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Douglas Hanly Moir , Sydney, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Westmead Hospital , Sydney, NSW 2145 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Manzie","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Chris O\u2019Brien Lifehouse Hospital , Sydney, NSW 2050 ,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Westmead Hospital , Sydney, NSW 2145 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel A","family":"Vanderniet","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, NSW 2050 ,","place":["Australia"]},{"name":"Institute of Endocrinology and Diabetes, The Children\u2019s Hospital at Westmead , Sydney, NSW 2145 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Ji Jina","family":"Rhou","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Westmead Hospital , Sydney, NSW 2145 ,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, NSW 2050 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8746-5529","authenticated-orcid":false,"given":"Christian M","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology, Westmead Hospital , Sydney, NSW 2145 ,","place":["Australia"]},{"name":"Faculty of Medicine and Health, University of Sydney , Sydney, NSW 2050 ,","place":["Australia"]},{"name":"Department of Endocrinology, Royal North Shore Hospital , Sydney, NSW 2065 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"issue":"3","key":"2026100119513093200_ref1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.joms.2005.11.006","article-title":"Giant-cell granuloma in the temporal bone: a case report and review of the literature","volume":"64","author":"Dimitrakopoulos","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"issue":"1","key":"2026100119513093200_ref2","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/ams.ams_232_18","article-title":"Management of central giant cell granulomas of the jaws: an unusual case report with critical appraisal of existing 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