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The aims of this study were to determine if physiological and behavioral nutrition-related factors differ between people with and without AIS, and to quantify their relationship with AIS, in unbiased cohort sample. BMI, presence of an eating disorder, leptin, adiponectin, BMD, vitamin D, lean mass, and fat mass were compared between those with and without AIS at ages 8, 10, 14, 17, and 20\u00a0years, and multiple logistic regression was performed between these variables and AIS. Lower total body BMD (median, 1.0\u00a0g\/cm2 vs 1.1\u00a0g\/cm2; p\u2009=\u2009.03) and lean mass (median, 38.8\u00a0kg vs 46.0\u00a0kg; p\u2009=\u2009.04) at age 20\u00a0years were observed in those with AIS compared to those without scoliosis. At age 20, the odds of AIS were 3.23 times higher for adolescents with an eating disorder compared to those with no eating disorder (95% CI, 1.02\u20138.63) when adjusted for BMI. Every 1\u00a0kg\/m2 increase in BMI decreased the odds of AIS by 0.88 times (95% CI, 0.76\u20130.98), after adjusting for eating disorder diagnosis. In conclusion, lower BMI in mid-adolescence and presence of eating disorder outcomes, lower BMD, and lower lean mass in late adolescence were associated with the presence of AIS. Current data do not explain the mechanisms for these associations but suggest that serum leptin, adiponectin, and vitamin D are unlikely to be contributing factors. Conclusive determination of the prevalence of eating disorders in AIS will require further studies with larger sample sizes.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziad013","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T20:29:10Z","timestamp":1704313750000},"source":"Crossref","is-referenced-by-count":9,"title":["Comparison of physiological and behavioral nutrition-related factors in people with and without adolescent idiopathic scoliosis, from cohort data at 8 to 20\u00a0years"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-3383","authenticated-orcid":false,"given":"Phoebe T T","family":"Ng","sequence":"first","affiliation":[{"name":"The University of Queensland, Laboratory for Motor Control and Pain Research, School of Biomedical Sciences , St. Lucia, 4072, QLD , Australia"},{"name":"KK Women\u2019s and Children\u2019s Hospital , Physiotherapy Department, 229899 , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4976-7483","authenticated-orcid":false,"given":"Kylie","family":"Tucker","sequence":"additional","affiliation":[{"name":"The University of Queensland, Laboratory for Motor Control and Pain Research, School of Biomedical Sciences , St. Lucia, 4072, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2074-6999","authenticated-orcid":false,"given":"Syeda Farah","family":"Zahir","sequence":"additional","affiliation":[{"name":"The University of Queensland, Centre for Health Services Research, Faculty of Medicine , Woolloongabba, 4102, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4926-3077","authenticated-orcid":false,"given":"Maree T","family":"Izatt","sequence":"additional","affiliation":[{"name":"Queensland University of Technology at the Centre for Children\u2019s Health Research, Biomechanics and Spine Research Group , South Brisbane, 4101, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-4128","authenticated-orcid":false,"given":"Leon","family":"Straker","sequence":"additional","affiliation":[{"name":"Curtin University, School of Allied Health , Perth, 6102, WA , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-9697","authenticated-orcid":false,"given":"Andrew","family":"Claus","sequence":"additional","affiliation":[{"name":"The University of Queensland, School of Health and Rehabilitation Sciences , St. Lucia, 4072, QLD , Australia"},{"name":"Royal Brisbane and Women\u2019s Hospital, Tess Cramond Pain and Research Centre , Herston, 4029, QLD , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,4]]},"reference":[{"issue":"8","key":"2024032909000614800_ref1","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1002\/jbmr.2207","article-title":"Association between components of body composition and scoliosis: a prospective cohort study reporting differences identifiable before the onset of scoliosis","volume":"29","author":"Clark","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024032909000614800_ref2","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s00586-012-2465-y","article-title":"Body composition in adolescent idiopathic scoliosis","volume":"22","author":"Ramirez","year":"2013","journal-title":"Eur Spine J"},{"issue":"8","key":"2024032909000614800_ref3","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.spinee.2013.09.034","article-title":"Association between body mass index, body height, and the prevalence of spinal deformities","volume":"14","author":"Hershkovich","year":"2014","journal-title":"Spine J"},{"issue":"1","key":"2024032909000614800_ref4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/10640260701773660","article-title":"The prevalence of eating disorders in adolescents with idiopathic scoliosis","volume":"16","author":"Alborghetti","year":"2007","journal-title":"Eat Disord"},{"issue":"1","key":"2024032909000614800_ref5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jadohealth.2007.08.008","article-title":"Do chronic medical conditions increase the risk of eating disorder? 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