{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:23:52Z","timestamp":1780892632937,"version":"3.54.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R21AG044858"],"award-info":[{"award-number":["R21AG044858"]}]},{"name":"National Institute of Health","award":["R15AG055029"],"award-info":[{"award-number":["R15AG055029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The magnitude of bone formation and remodeling is linked to both the magnitude of strain placed on the bone and the perfusion of bone. It was previously reported that an increase in bone perfusion and bone density occurs in the femur of old rats with moderate aerobic exercise training. This study determined the acute and chronic effects of static muscle stretching on bone blood flow and remodeling. Old male Fischer 344 rats were randomized to either a naive or stretch-trained group. Static stretching of ankle flexor muscles was achieved by placement of a dorsiflexion splint on the left ankle for 30\u00a0min\/d, 5d\/wk for 4wk. The opposite hindlimb served as a contralateral control (nonstretched) limb. Bone blood flow was assessed during and after acute stretching in naive rats, and at rest and during exercise in stretch-trained rats. Vascular reactivity of the nutrient artery of the proximal tibia was also assessed in stretch-trained rats. MicroCT analysis was used to assess bone volume and micro-architecture of the trabecular bone of both tibias near that growth plate. In naive rats, static stretching increased blood flow to the proximal tibial metaphasis. Blood flow to the proximal tibial metaphysis during treadmill exercise was higher in the stretched limb after 4\u00a0wk of daily stretching. Daily stretching also increased tibial bone weight and increased total volume in both the proximal and distal tibial metaphyses. In the trabecular bone immediately below the proximal tibial growth plate, total volume and bone volume increased, but bone volume\/total volume was unchanged and trabecular connectivity decreased. In contrast, intravascular volume increased in this region of the bone. These data suggest that blood flow to the tibia increases during bouts of static stretching of the hindlimb muscles, and that 4\u00a0wk of daily muscle stretching leads to bone remodeling and an increase in intravascular volume of the tibial bone.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziad019","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T22:03:52Z","timestamp":1704405832000},"source":"Crossref","is-referenced-by-count":4,"title":["Adaptations of bone and bone vasculature to muscular stretch training"],"prefix":"10.1093","volume":"8","author":[{"given":"Julia","family":"Eazer","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Florida State University , Tallahassee, Fl, 32304 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Barsoum","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Florida State University , Tallahassee, Fl, 32304 , United 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