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Rapamycin is an FDA-approved immunosuppressant that inhibits the mechanistic target of rapamycin (mTOR) complex, extends lifespan, and protects against aging-related diseases in multiple species; however, the impact of rapamycin on skeletal tissue is incompletely understood. We evaluated the effects of a short-term, low-dosage, interval rapamycin treatment on bone microarchitecture and strength in young-adult (3 mo old) and aged female (20 mo old) C57BL\/6 mice. Rapamycin (2\u00a0mg\/kg body mass) was administered via intraperitoneal injection 1\u00d7\/5\u00a0d for a duration of 8\u00a0wk; this treatment regimen has been shown to induce geroprotective effects while minimizing the side effects associated with higher rapamycin dosages and\/or more frequent or prolonged delivery schedules. Aged femurs exhibited lower cancellous bone mineral density, volume, trabecular connectivity density and number, higher trabecular thickness and spacing, and lower cortical thickness compared to young-adult mice. Rapamycin had no impact on assessed microCT parameters. Flexural testing of the femur revealed that both yield strength and ultimate strength were lower in aged mice compared to young-adult mice. There were no effects of rapamycin on these or other measures of bone biomechanics. Age, but not rapamycin, altered local and global measures of bone turnover. These data demonstrate that short-term, low-dosage interval rapamycin treatment does not negatively or positively impact the skeleton of young-adult and aged mice.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae001","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:05:40Z","timestamp":1704927940000},"source":"Crossref","is-referenced-by-count":10,"title":["Rapamycin does not alter bone microarchitecture or material properties quality in young-adult and aged female C57BL\/6 mice"],"prefix":"10.1093","volume":"8","author":[{"given":"Connor C","family":"Devine","sequence":"first","affiliation":[{"name":"Chemical and Biological Engineering Department , , Bozeman, MT 59718 , United States"},{"name":"Montana State University , , Bozeman, MT 59718 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenna C","family":"Brown","sequence":"additional","affiliation":[{"name":"Mechanical and Industrial Engineering Department , , Bozeman, MT 59718 , United States"},{"name":"Montana State University , , Bozeman, MT 59718 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kat O","family":"Paton","sequence":"additional","affiliation":[{"name":"Translational Biomarkers Core Laboratory , , Bozeman, MT 59718 , United States"},{"name":"Center for American Indian and Rural Health Equity, Montana State University , , Bozeman, MT 59718 , United States"},{"name":"Biology of Aging Laboratory , , Bozeman, MT 59718 , United States"},{"name":"Center for American Indian and Rural Health Equity, Montana State University , , Bozeman, MT 59718 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea M","family":"Heveran","sequence":"additional","affiliation":[{"name":"Mechanical and Industrial Engineering Department , , Bozeman, MT 59718 , United States"},{"name":"Montana State University , , Bozeman, MT 59718 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A","family":"Martin","sequence":"additional","affiliation":[{"name":"Translational Biomarkers Core Laboratory , , Bozeman, MT 59718 , United States"},{"name":"Center for American Indian and Rural Health Equity, Montana State University , , Bozeman, MT 59718 , United States"},{"name":"Biology of Aging Laboratory , , Bozeman, MT 59718 , United States"},{"name":"Center for American Indian and Rural Health Equity, Montana State University , , Bozeman, MT 59718 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"issue":"11","key":"2024050604565147000_ref1","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1002\/jbmr.488","article-title":"Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop","volume":"26","author":"Khosla","year":"2011","journal-title":"J Bone Miner 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