{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:20:43Z","timestamp":1780338043568,"version":"3.54.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"KU Leuven Internal Funds","award":["C24\/16\/027"],"award-info":[{"award-number":["C24\/16\/027"]}]},{"name":"Excellence of Science programme","award":["40007553"],"award-info":[{"award-number":["40007553"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Knee osteoarthritis is a whole joint disease highlighting the coupling of cartilage and bone adaptations. However, the structural properties of the subchondral bone plate (SBP) and underlying subchondral trabecular bone (STB) in the femoral compartment have received less attention compared to the tibial side. Furthermore, how the properties in the femoral compartment relate to those in the corresponding tibial site is unknown. Therefore, this study aimed to quantify the structural bone and cartilage morphology in the femoral compartment and investigate its association with those of the tibial plateau. Specifically, tibial plateaus and femoral condyles were retrieved from 28 patients with end-stage knee-osteoarthritis (OA) and varus deformity. The medial condyle of tibial plateaus and the distal part of the medial femoral condyles were micro-CT scanned (20.1\u00a0\u03bcm\/voxel). Cartilage thickness (Cart.Th), SBP, and STB microarchitecture were quantified. Significant (P\u00a0&amp;lt;\u2009&amp;lt;.001; 0.79\u2009\u2264\u00a0r\u00a0\u2264\u20090.97) correlations with a relative difference within 10% were found between the medial side of the femoral and tibial compartments. The highest correlations were found for SBP porosity (r\u00a0=\u20090.97, mean absolute difference of 0.50%, and mean relative difference of 9.41%) and Cart.Th (r\u00a0=\u20090.96, mean absolute difference of 0.18\u00a0mm, and relative difference of 7.08%). The lowest correlation was found for trabecular thickness (r\u00a0=\u20090.79, mean absolute difference of 21.07\u00a0\u03bcm, and mean relative difference of 5.17%) and trabecular number (r\u00a0=\u20090.79, mean absolute difference of 0.18\u00a0mm\u22121, and relative difference of 5.02%). These findings suggest that the distal femur is affected by OA in a similar way as the proximal tibia. Given that bone adaptation is a response to local mechanical forces, our results suggest that varus deformity similarly affects the stress distribution of the medial tibial plateau and the medial distal femur.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae014","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:26:56Z","timestamp":1706833616000},"source":"Crossref","is-referenced-by-count":3,"title":["Correlation between tibial and femoral bone and cartilage changes in end-stage knee osteoarthritis"],"prefix":"10.1093","volume":"8","author":[{"given":"Fahimeh","family":"Azari","sequence":"first","affiliation":[{"name":"Biomechanics Section , Mechanical Engineering, , Leuven , Belgium"},{"name":"KU Leuven , Mechanical Engineering, , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Colyn","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, AZ Turnhout , Turnhout , Belgium"},{"name":"Faculty of Medicine and Life Sciences, Hasselt University , Diepenbeek , Belgium"},{"name":"Limburg Clinical Research Center, ZOL Genk , Genk , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Bellemans","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Life Sciences, Hasselt University , Diepenbeek , Belgium"},{"name":"GRIT Belgian Sports Clinic , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Scheys","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University Hospitals Leuven , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Harry","family":"van Lenthe","sequence":"additional","affiliation":[{"name":"Biomechanics Section , Mechanical Engineering, , Leuven , Belgium"},{"name":"KU Leuven , Mechanical Engineering, , Leuven , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"issue":"9859","key":"2024041108502113000_ref1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"issue":"9","key":"2024041108502113000_ref2","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/jor.23474","article-title":"Systematic mapping of the subchondral bone 3D microarchitecture in the human tibial plateau: variations with joint alignment","volume":"35","author":"Roberts","year":"2017","journal-title":"J Orthop 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