{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:46Z","timestamp":1753877086844,"version":"3.41.2"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006313","name":"Swedish Childhood Cancer Foundation","doi-asserted-by":"publisher","award":["ST2013-0008","TJ2020-0069","PR2021-0090"],"award-info":[{"award-number":["ST2013-0008","TJ2020-0069","PR2021-0090"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mary B\u00e9ves Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Children with hemato-oncological diseases may have significant skeletal morbidity, not only during and after treatment but also at the time of diagnosis before cancer treatment. This study was designed to evaluate the vitamin D status and circulating bone metabolic markers and their determinants in children at the time of diagnostic evaluation for hemato-oncological disease.<\/jats:p>\n               <jats:p>This cross-sectional study included 165 children (91 males, median age 6.9\u00a0yr range 0.2\u201317.7\u00a0yr). Of them, 76 patients were diagnosed with extracranial or intracranial solid tumors, 83 with leukemia, and 6 with bone marrow failure. Bone metabolism was assessed by measuring serum 25OHD, PTH, bone alkaline phosphatase, intact N-terminal propeptide of type I procollagen, and C-terminal cross-linked telopeptide of type I collagen.<\/jats:p>\n               <jats:p>Vitamin D deficiency was found in 30.9% of children. Lower 25OHD levels were associated with older age, lack of vitamin D supplementation, season outside summer, and a country of parental origin located between latitudes \u221245\u00b0 and 45\u00b0. Children diagnosed with leukemia had lower levels of markers of bone formation and bone resorption than those who had solid tumors or bone marrow failure.<\/jats:p>\n               <jats:p>In conclusion, vitamin D deficiency was observed in one-third of children with newly diagnosed cancer. Bone turnover markers were decreased in children with leukemia, possibly because of the suppression of osteoblasts and osteoclasts by leukemic cells. The identification of patients with suboptimal vitamin D status and compromised bone remodeling at cancer diagnosis may aid in the development of supportive treatment to reduce the adverse effects of cancer and its treatment.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae017","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T20:57:16Z","timestamp":1708808236000},"source":"Crossref","is-referenced-by-count":2,"title":["Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-3299","authenticated-orcid":false,"given":"Natalja","family":"Jackmann","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University and University Children\u2019s Hospital , Uppsala 75185 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University and University Children\u2019s Hospital , Uppsala 75185 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauliina","family":"Utriainen","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital , Helsinki 00014 , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-7838","authenticated-orcid":false,"given":"Per","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry , and Department of Biomedical and Clinical Sciences, , Link\u00f6ping 58183 , Sweden"},{"name":"Link\u00f6ping University , and Department of Biomedical and Clinical Sciences, , Link\u00f6ping 58183 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arja","family":"Harila","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University and University Children\u2019s Hospital , Uppsala 75185 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-3134","authenticated-orcid":false,"given":"Diana","family":"Atanasova","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry , and Department of Biomedical and Clinical Sciences, , Link\u00f6ping 58183 , Sweden"},{"name":"Link\u00f6ping University , and Department of Biomedical and Clinical Sciences, , Link\u00f6ping 58183 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Rinaldo","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health, Karolinska Institute , Stockholm 17177 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Frisk","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Uppsala University and University Children\u2019s Hospital , Uppsala 75185 , Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-001X","authenticated-orcid":false,"given":"Outi","family":"M\u00e4kitie","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital , Helsinki 00014 , Finland"},{"name":"Department of Molecular Medicine and Surgery , Karolinska Institute, and Clinical Genetics, , Stockholm 17177 , Sweden"},{"name":"Karolinska University Hospital , Karolinska Institute, and Clinical Genetics, , Stockholm 17177 , 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