{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:55:22Z","timestamp":1784994922609,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vitamin D deficiency during infancy has been associated with increased bone turnover rate and bone mineral loss. However, few studies have examined bone turnover markers (BTMs) for both bone formation and resorption in infants with vitamin D deficiency. Here, we analyzed serum concentrations of 25OHD, intact parathormone (iPTH), and BTMs including total alkaline phosphatase (ALP), tartrate-resistant acid phosphatase isoform 5b (TRACP-5b), and serum type I collagen N-telopeptide (NTx) as well as basic clinical characteristics of 456 infants (626 samples) aged less than 12\u00a0mo born at Saitama City Hospital, Japan (latitude 35.9\u00b0 North) between January 2021 and December 2022. One hundred sixteen infants (147 samples) were classified as having vitamin D deficiency (25OHD\u2009&amp;lt;\u200912.0\u00a0ng\/mL), and 340 infants (479 samples) had sufficient vitamin D levels (25OHD\u2009\u2265\u200912.0\u00a0ng\/mL). In addition to 25OHD and ALP, both TRACP-5b and sNTx were measured in 331 infants (418 samples), while 90 infants (105 samples) had only TRACP-5b measured and 101 infants (103 samples) had only sNTx measured. Statistical comparison of 104 subjects each in the vitamin D deficiency and sufficiency groups after matching for the background characteristics revealed that the vitamin D deficiency group had significantly higher levels of ALP and iPTH compared with the sufficiency group (P\u2009=\u2009&amp;lt;.0001, .0012, respectively). However, no significant differences were found in TRACP-5b and NTx levels between the 2 groups (P\u2009=\u2009.19, .08, respectively). Our findings suggest discordant responses between bone formation and resorption markers in subclinical vitamin D deficiency during infancy.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae033","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T21:57:14Z","timestamp":1710799034000},"source":"Crossref","is-referenced-by-count":3,"title":["Discordant responses of bone formation and absorption markers in Japanese infants with vitamin D deficiency: a comprehensive matched case\u2013control study"],"prefix":"10.1093","volume":"8","author":[{"given":"Keigo","family":"Takahashi","sequence":"first","affiliation":[{"name":"Saitama City Hospital Division of Neonatology, Department of Pediatrics, , Saitama, 336-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Saitama City Hospital Division of Neonatology, Department of Pediatrics, , Saitama, 336-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Hara-Isono","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine Department of Pediatrics, , Tokyo, 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Nitta","sequence":"additional","affiliation":[{"name":"Saitama Medical Center, Dokkyo Medical University Department of Pediatrics, , Saitama, 343-0845, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Nagano","sequence":"additional","affiliation":[{"name":"Nihon University School of Medicine Department of Pediatrics and Child Health, , Tokyo, 173-8610, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Arimitsu","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine Department of Pediatrics, , Tokyo, 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,18]]},"reference":[{"key":"2024041503555888000_ref1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/B978-0-12-809965-0.00040-9","volume-title":"Vitamin D","author":"Cooper","year":"2018","edition":"4th"},{"key":"2024041503555888000_ref2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/CBO9780511544712.016","volume-title":"Neonatal Nutrition and Metabolism","author":"Itani","year":"2006","edition":"2nd ed."},{"issue":"2","key":"2024041503555888000_ref3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00223-022-00964-2","article-title":"Bone turnover markers in children: from laboratory challenges to clinical interpretation","volume":"112","author":"Ladang","year":"2023","journal-title":"Calcif Tissue 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