{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:04:46Z","timestamp":1781175886885,"version":"3.54.1"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NIAMS","award":["R01 AR078764"],"award-info":[{"award-number":["R01 AR078764"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Low back pain derived from intervertebral disc (IVD) degeneration is a debilitating spinal condition that, despite its prevalence, does not have any intermediary guidelines for pharmacological treatment between palliative care and invasive surgery. The development of treatments for the IVD is complicated by the variety of resident cell types needed to maintain the regionally distinct structural properties of the IVD that permit the safe, complex motions of the spine. Osteoporosis of the spine increases the risk of vertebral bone fracture that can increase the incidence of back pain. Fortunately, there are a variety of pharmacological treatments for osteoporosis that target osteoblasts, osteoclasts and\/or osteocytes to build bone and prevent vertebral fracture. Of particular note, clinical and preclinical studies suggest that commonly prescribed osteoporosis drugs like bisphosphonates, intermittent parathyroid hormone, anti-sclerostin antibody, selective estrogen receptor modulators and anti-receptor activator of nuclear factor-kappa B ligand inhibitor denosumab may also relieve back pain. Here, we cite clinical and preclinical studies and include unpublished data to support the argument that a subset of these therapeutics for osteoporosis may alleviate low back pain by also targeting the IVD.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae048","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T22:51:13Z","timestamp":1713394273000},"source":"Crossref","is-referenced-by-count":8,"title":["Osteoporosis treatments for intervertebral disc degeneration and back pain: a perspective"],"prefix":"10.1093","volume":"8","author":[{"given":"Neharika","family":"Bhadouria","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , United States"},{"name":"School of Mechanical Engineering, Purdue University , West Lafayette, IN 47907 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-845X","authenticated-orcid":false,"given":"Nilsson","family":"Holguin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Icahn School of Medicine at Mount Sinai , New York, NY 10029 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"issue":"6","key":"2024050707495271200_ref1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/annrheumdis-2013-204344","article-title":"The global burden of musculoskeletal conditions for 2010: an overview of methods","volume":"73","author":"Hoy","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2024050707495271200_ref2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.spinee.2011.09.002","article-title":"Low back pain in the United States: incidence and risk factors for presentation 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