{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:37:08Z","timestamp":1786725428429,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Research Supporting Program of the Korean Association"},{"name":"Study of the Liver and The Korean Liver Foundation","award":["KASLKLF2022-05"],"award-info":[{"award-number":["KASLKLF2022-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Large-scale studies on the risk of fragility fractures in patients with primary biliary cholangitis (PBC) are limited due to low incidence. We aimed to investigate whether PBC is associated with fragility fractures using real-world nationwide data. The Korean National Health Insurance Service claims data from 2007 to 2020 were analyzed in this population-based cohort study. Patients with PBC (n\u2009=\u20094951) were matched with controls (n\u2009=\u200919\u2009793) using a 1:4 ratio based on age, sex, and follow-up duration. The primary outcome was fragility fracture, which comprised fractures of the vertebra, hip, distal radius, and proximal humerus. The incidence rates (IRs) and hazard ratios (HRs) were determined to assess the impact of PBC on fragility fractures. During the median follow-up period of 5.37\u00a0years, 524 patients in the PBC group had fragility fractures (IR, 18.59\/1000 person-years [PYs]). After adjusting for covariates, PBC increased the risk of fragility fractures by 1.63-fold (95% confidence interval, 1.20\u20132.22; P\u2009=\u2009.002). The vertebra and hip were particularly susceptible to fracture in patients with PBC, with adjusted HRs of 1.77 and 2.23, respectively. In the subgroup analysis, the risk of fragility fracture was 2.53-fold higher in men and 1.59-fold higher in women with PBC than that in the respective matched control groups. Considering the morbidity and mortality related to fragility fractures, increasing awareness of fragility fracture risk and implementing appropriate preventive measures in patients with PBC are imperative.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae056","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T20:56:48Z","timestamp":1713560208000},"source":"Crossref","is-referenced-by-count":4,"title":["Increased risk of fragility fractures in patients with primary biliary cholangitis"],"prefix":"10.1093","volume":"8","author":[{"given":"Jihye","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology , Department of Internal Medicine, Yeouido St. Mary\u2019s Hospital, College of Medicine, , Seoul, 07345 , Republic of Korea"},{"name":"The Catholic University of Korea , Department of Internal Medicine, Yeouido St. Mary\u2019s Hospital, College of Medicine, , Seoul, 07345 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Jee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics , Asan Medical Center, , Seoul, 05505 , Republic of Korea"},{"name":"University of Ulsan College of Medicine , Asan Medical Center, , Seoul, 05505 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics , Asan Medical Center, , Seoul, 05505 , Republic of Korea"},{"name":"University of Ulsan College of Medicine , Asan Medical Center, , Seoul, 05505 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonggi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology , Liver Center, Asan Medical Center, , Seoul, 05505 , Republic of Korea"},{"name":"University of Ulsan College of Medicine , Liver Center, Asan Medical Center, , Seoul, 05505 , Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"issue":"1","key":"2024060913315573800_ref1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2017.03.022","article-title":"EASL clinical practice guidelines: the diagnosis and management of patients with primary biliary cholangitis","volume":"67","author":"Hirschfield","year":"2017","journal-title":"J Hepatol"},{"issue":"1","key":"2024060913315573800_ref2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/hep.30145","article-title":"Primary biliary cholangitis: 2018 practice guidance from the American Association for the Study of Liver 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