{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:04:46Z","timestamp":1785542686002,"version":"3.56.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK125252"],"award-info":[{"award-number":["R01 DK125252"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rochester Epidemiology Project"},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R33 AG058738"],"award-info":[{"award-number":["R33 AG058738"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mayo Clinic Research Committee"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In a previous study, we observed decreased 1,25-dihydroxyvitamin D levels, secondary hyperparathyroidism, and increased bone turnover markers in living kidney donors (LKDs) at 3\u00a0months and 36\u00a0months after kidney donation. In our recent survey-based study, we found no increased risk of fractures of all types but observed significantly more vertebral fractures in LKDs compared with matched controls. To elucidate the long-term effects of kidney donation on bone health, we recruited 139 LKDs and 139 age and sex matched controls from the survey-based participants for further mechanistic analyses. Specifically, we assessed whether LKDs had persistent abnormalities in calcium- and phosphorus-regulating hormones and related factors, in bone formation and resorption markers, and in density and microstructure of bone compared with controls. We measured serum markers, bone mineral density (BMD), bone microstructure and strength (via high-resolution peripheral quantitative computed tomography and micro-finite element analysis [HRpQCT]), and advanced glycation end-products in donors and controls. LKDs had decreased 1,25-dihydroxyvitamin D concentrations (donors mean 33.89\u00a0pg\/mL vs. controls 38.79\u00a0pg\/mL, percent difference\u2009=\u2009-12.6%; P\u00a0&amp;lt;\u2009.001), increases in both parathyroid hormone (when corrected for ionized calcium; donors mean 52.98\u00a0pg\/mL vs. controls 46.89\u00a0pg\/mL,% difference 13%; P\u00a0=\u2009.03) and ionized calcium levels (donors mean 5.13\u00a0mg\/dL vs. controls 5.04\u00a0mg\/dL; P\u00a0&amp;lt;\u2009.001), and increases in several bone resorption and formation markers versus controls. LKDs and controls had similar measures of BMD; however, HRpQCT suggested that LKDs have a statistically insignificant tendency toward thinner cortical bone and lower failure loads as measured by micro-finite element analysis. Our findings suggest that changes in the hormonal mileu after kidney donation and the long-term cumulative effects of these changes on bone health persist for decades after kidney donation and may explain later-life increased rates of vertebral fractures.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae067","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T17:06:44Z","timestamp":1715620004000},"source":"Crossref","is-referenced-by-count":2,"title":["Persistent changes in calcium-regulating hormones and bone turnover markers in living kidney donors more than 20\u00a0years after donation"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-9061","authenticated-orcid":false,"given":"Brandon R","family":"Grossardt","sequence":"first","affiliation":[{"name":"Division of Clinical Trials and Biostatistics , Department of Quantitative Health Sciences, , Rochester, MN 55905 , United States"},{"name":"Mayo Clinic , Department of Quantitative Health Sciences, , Rochester, MN 55905 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal","family":"Maradit Kremers","sequence":"additional","affiliation":[{"name":"Division of Epidemiology , Department of Quantitative Health Sciences, , Rochester, MN 55905 , United States"},{"name":"Mayo Clinic , Department of Quantitative Health Sciences, , Rochester, MN 55905 , United States"},{"name":"Department of Orthopedics, Mayo Clinic , Rochester, MN 55905 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R","family":"Miller","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation Clinical Research and Regeneration, Mayo Clinic , Rochester, MN 55905 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertram L","family":"Kasiske","sequence":"additional","affiliation":[{"name":"Division of Nephrology , Department of Medicine, , Minneapolis, MN 55415 , United States"},{"name":"Hennepin County Medical Center , Department of Medicine, , Minneapolis, MN 55415 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J","family":"Matas","sequence":"additional","affiliation":[{"name":"Division of Transplantation , Department of Surgery, , Minneapolis, MN 55455 , United States"},{"name":"University of Minnesota , Department of Surgery, , Minneapolis, MN 55455 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology , Diabetes and Metabolism, Department of Medicine and Kogod Center on Aging, , Rochester, MN 55905 , United States"},{"name":"Mayo Clinic , Diabetes and Metabolism, Department of Medicine and Kogod Center on Aging, , Rochester, MN 55905 , United States"},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic , Rochester, MN 55905 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter K","family":"Kremers","sequence":"additional","affiliation":[{"name":"Division of Clinical Trials and Biostatistics , Department of Quantitative Health Sciences, , Rochester, MN 55905 , United States"},{"name":"Mayo Clinic , Department of Quantitative Health Sciences, , Rochester, MN 55905 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Amer","sequence":"additional","affiliation":[{"name":"William J. von Liebig Center for Transplantation Clinical Research and Regeneration, Mayo Clinic , Rochester, MN 55905 , United States"},{"name":"Division of Nephrology and Hypertension , Department of Medicine, , Rochester, MN 55905 , United States"},{"name":"Mayo Clinic , Department of Medicine, , Rochester, MN 55905 , United 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