{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:25:05Z","timestamp":1787505905858,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"DOI":"10.13039\/501100003593","name":"Brazilian Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["2019\/14583-4"],"award-info":[{"award-number":["2019\/14583-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Brazilian Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["402626\/2021-4"],"award-info":[{"award-number":["402626\/2021-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Muscle weakness is a common symptom in CKD patients, and the pathway by which secondary hyperparathyroidism (SHPT) affects muscle function is unknown. Osteopontin (OPN), a bone matrix protein stimulated by PTH and phosphate, has been associated with inflammatory muscle diseases. In this observational and prospective cohort study, we evaluated 30 patients with severe SHPT (39\u2009\u00b1\u200912\u00a0yr; 18 women), before and 6\u00a0mo after parathyroidectomy (PTx). We examined the relationships among CKD\u2013mineral and bone disorder parameters; myokine and inflammatory cytokine levels; and changes in resting energy expenditure (REE), muscle function, BMD, and muscle-related proteins. At baseline, the patients showed low gene expression of muscle turnover markers and irisin, as well as high protein expression of OPN, transforming growth factor beta (TGF-\u03b2), and fibroblast growth factor 21. Six months after PTx, REE and muscle mass had not changed, but physical performance, muscle strength, and bone mass improved, more so in patients undergoing total PTx. Also, there were reductions in the protein expression of OPN (11 vs 3%, p=.01) and TGF-\u03b2 (21 vs 7%, p=.002) in muscle, together with a significant increase in irisin muscular levels (30 vs 35\u00a0pg\/mg, p=.02). The gain in bone mass and the increase in irisin levels correlated with a reduction in PTH. The levels of interleukin (IL)-1\u03b2, tumor necrosis factor alpha, and IL-17 (markers of myositis) were also lower after PTx. Our data suggest that SHPT plays a role in CKD-induced muscle dysfunction, indirectly, via release of bone-specific proteins, which is partially reverted with PTx.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae084","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T19:07:37Z","timestamp":1719342457000},"source":"Crossref","is-referenced-by-count":5,"title":["The role of osteopontin and osteocyte-derived factors in secondary hyperparathyroidism-induced myopathy"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-9727","authenticated-orcid":false,"given":"Eduardo J","family":"Duque","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley F","family":"Crispilho","sequence":"additional","affiliation":[{"name":"Department of Post Graduation, Universidade Nove de Julho , S\u00e3o Paulo, SP, 01156-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivone B","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner V","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleonice","family":"Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzia","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 K","family":"Teng","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla M","family":"Avesani","sequence":"additional","affiliation":[{"name":"Karolinska Institute Division of Renal Medicine \u2013 Baxter Novum, Department of Clinical Science, Intervention and Technology, , Stockholm, 141 86, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel K","family":"Shinjo","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Rheumatology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosilene M","family":"Elias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"},{"name":"Department of Post Graduation, Universidade Nove de Julho , S\u00e3o Paulo, SP, 01156-050, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda","family":"Jorgetti","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M A","family":"Moys\u00e9s","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Renal 16 (LIM 16), Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo Nephrology Department, , S\u00e3o Paulo, SP, 01246-903, 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