{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:39:27Z","timestamp":1785451167426,"version":"3.56.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceutical Company Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypoparathyroidism is a rare endocrine disorder characterized by low serum calcium and elevated serum phosphorus levels. Patients who do not recover parathyroid function after surgeries or have nonsurgical causes involving congenital and metabolic diseases, require long-term use of active vitamin D and calcium supplementation as conventional therapy in Japan. This study aimed to estimate prevalence of chronic hypoparathyroidism and investigate its disease etiology, patient characteristics, and treatment in Japan, using a health insurance claim database. Individuals who were available in the 4-yr observation period spanning 2015\u20132018 (2015\u20132017 for look-back and 2018 for prevalence estimation) were eligible for the denominator. Chronic hypoparathyroidism was defined as individuals who had both a record of prescription of conventional therapy for hypoparathyroidism in 2018 and a record of relevant surgery, radiotherapy, or disease at least 6\u00a0mo apart. Among the denominator (N\u2009=\u20092\u2009241\u2009717), 509 patients with chronic hypoparathyroidism were identified (mean age of 49\u00a0yr). The standardized prevalence of chronic hypoparathyroidism in 2018 was 38.3 (95% CI: 33.4\u201343.6) per 100\u2009000 individuals, with 37.0 (32.2\u201342.3) and 1.2 (0.8\u20132.0) per 100\u2009000 for postoperative and nonoperative causes, respectively. Six percent of the patients had chronic kidney disease as a comorbidity. Chronic hypoparathyroidism had heterogenous causes, with thyroid malignancy and 22q11.2 deletion syndrome being the most common postoperative and nonoperative causes, respectively. The mean duration of prescribed vitamin D and calcium was 963 and 629\u00a0d, respectively, during the 4-yr period. The prevalence of chronic hypoparathyroidism was similar but slightly higher than estimates reported for the United States and Europe, which may be due to the differences in study designs and high healthcare accessibility in Japan. Our study suggests that there is a nonnegligible number of patients, ~48\u2009500 patients, with chronic hypoparathyroidism in Japan.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae100","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T23:44:24Z","timestamp":1722037464000},"source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and characteristics of postoperative and nonoperative chronic hypoparathyroidism in Japan: a nationwide retrospective analysis"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-6304","authenticated-orcid":false,"given":"Miyuki","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Patient Safety & Pharmacovigilance Japan , Takeda Development Center Japan, , Osaka 540-8645, Japan"},{"name":"Takeda Pharmaceutical Company Limited , Takeda Development Center Japan, , Osaka 540-8645, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Patient Safety & Pharmacovigilance Japan , Takeda Development Center Japan, , Osaka 540-8645, Japan"},{"name":"Takeda Pharmaceutical Company Limited , Takeda Development Center Japan, , Osaka 540-8645, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Endocrine Center, Toranomon Hospital , Tokyo 105-8470, Japan"},{"name":"Okinaka Memorial Institute for Medical Research , Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Sugitani","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Nippon Medical School Graduate School of Medicine , Tokyo 113-8603, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Osaka University Graduate School of Medicine , Osaka 565-0871, Japan"},{"name":"Department of Pediatrics, ISEIKAI International General Hospital , Osaka 530-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia","family":"Castriota","sequence":"additional","affiliation":[{"name":"Global Evidence and Outcomes , Data Science Institute, , Cambridge, MA 02142, United States"},{"name":"Takeda Pharmaceutical Company Limited , Data Science Institute, , Cambridge, MA 02142, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olulade","family":"Ayodele","sequence":"additional","affiliation":[{"name":"Global Evidence and Outcomes , Data Science Institute, , Cambridge, MA 02142, United States"},{"name":"Takeda Pharmaceutical Company Limited , Data Science Institute, , Cambridge, MA 02142, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Patient Safety & Pharmacovigilance Japan , Takeda Development Center Japan, , Osaka 540-8645, Japan"},{"name":"Takeda Pharmaceutical Company Limited , Takeda Development Center Japan, , Osaka 540-8645, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"issue":"10","key":"2024082707555584100_ref1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2024082707555584100_ref2","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1210\/jc.2015-3908","article-title":"Epidemiology and diagnosis of hypoparathyroidism","volume":"101","author":"Clarke","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2024082707555584100_ref3","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1007\/s12325-021-01658-1","article-title":"Risk of chronic kidney disease and estimated glomerular filtration rate decline in patients with chronic hypoparathyroidism: a retrospective cohort study","volume":"38","author":"Gosmanova","year":"2021","journal-title":"Adv Ther"},{"issue":"11","key":"2024082707555584100_ref4","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1002\/jbmr.2273","article-title":"Postsurgical hypoparathyroidism - risk of fractures, psychiatric diseases, cancer, cataract, and infections","volume":"29","author":"Underbjerg","year":"2014","journal-title":"J Bone Miner Res"},{"key":"2024082707555584100_ref5","volume-title":"Fukukoujousen Kinou Teikashou (Shitei Nanbyou 235)"},{"issue":"12","key":"2024082707555584100_ref6","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1210\/jc.2012-1808","article-title":"Long-term follow-up of patients with hypoparathyroidism","volume":"97","author":"Mitchell","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2024082707555584100_ref7","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1080\/13696998.2019.1624081","article-title":"Clinical burden and healthcare resource utilization among patients with chronic hypoparathyroidism, overall and by adequately vs not adequately controlled disease: a multi-country chart review","volume":"22","author":"Chen","year":"2019","journal-title":"J Med Econ"},{"issue":"12","key":"2024082707555584100_ref8","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/jbmr.2004","article-title":"Prevalence and incidence of hypoparathyroidism in the United States using a large claims database","volume":"28","author":"Powers","year":"2013","journal-title":"J Bone Miner Res"},{"key":"2024082707555584100_ref9","first-page":"S182","article-title":"Co-morbid medical conditions associated with prevalent hypoparathyroidism: a population-based study","volume":"26","author":"Clarke","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2024082707555584100_ref10","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/jbmr.1979","article-title":"Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study","volume":"28","author":"Underbjerg","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2024082707555584100_ref11","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/jbmr.2501","article-title":"The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study","volume":"30","author":"Underbjerg","year":"2015","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024082707555584100_ref12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s00223-018-0405-5","article-title":"Prevalence of chronic hypoparathyroidism in a Mediterranean region as estimated by the analysis of anonymous healthcare database","volume":"103","author":"Cianferotti","year":"2018","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"2024082707555584100_ref13","first-page":"51","article-title":"Prevalence of postsurgical hypoparathyroidism in Japan: estimated from the data of multiple institutes. Nihon niokeru jutsugosei fukukojosen kinou teikashou no hindo chosa. 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