{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:45:38Z","timestamp":1767980738757,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018286","name":"Dutch Arthritis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic nonbacterial osteitis (CNO) is a rare auto-inflammatory bone disease affecting children and adults. Adult CNO is characterized by painful bone lesions, primarily of the anterior chest wall. There is no approved therapy for adult CNO. Current off-label treatments include intravenous bisphosphonates, which have been shown to alleviate pain through decreasing bone turnover. However, no adequately powered randomized controlled trials (RCTs) have been conducted. This double-blind, placebo-controlled RCT investigates the efficacy of intravenous pamidronate to decrease bone pain in adult CNO patients. Recruiting at the Dutch national referral center for CNO, adult patients with persistent bone pain despite non-steroidal anti-inflammatory drugs, or optionally other standard-of-care treatments are randomized to receive two courses of intravenous pamidronate (at 0 and 3\u00a0mo, 30\u00a0mg daily, on 3 consecutive d) or placebo. From 6\u00a0mo onwards, all patients receive open-label pamidronate for another two courses. The primary outcome is change in score for maximum pain from 0 to 6\u00a0mo. Secondary outcomes include change in quantitative intralesional bone turnover as measured on sodium-fluoride positron emission computed tomography ([18F]NaF-PET\/CT), inflammation markers, shoulder function, general health, quality of life, fatigue, physical, and work activity. The pamidronate for pain in adult chronic nonbacterial osteitis trial addresses the need for evidence-based treatments in adult CNO. Results will directly impact daily clinical practice, either validating the use of intravenous pamidronate in CNO at the dose used in this trial or prompting the search for alternative regimens or agents. This trial was registered in EudraCT (reference 2020-001068-27) and the Dutch Trial Register (reference NL68020.058.20).<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae114","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T20:04:45Z","timestamp":1724789085000},"source":"Crossref","is-referenced-by-count":6,"title":["Pamidronate for pain in adult chronic nonbacterial osteitis: protocol of a randomized, double-blind, placebo-controlled trial"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-9521","authenticated-orcid":false,"given":"Anne T","family":"Leerling","sequence":"first","affiliation":[{"name":"Department of Internal Medicine , Division of Endocrinology, , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Leiden University Medical Center , Division of Endocrinology, , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Center for Bone Quality, Leiden University Medical Center , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Department of Clinical Epidemiology, Leiden University Medical Center , Leiden, 2333 ZA,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Navas","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Center for Bone Quality, Leiden University Medical Center , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Department of Radiology , section of Nuclear Medicine, , Leiden, ZA 2333,","place":["the Netherlands"]},{"name":"Leiden University Medical Center , section of Nuclear Medicine, , Leiden, ZA 2333,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits","family":"Smit","sequence":"additional","affiliation":[{"name":"Center for Bone Quality, Leiden University Medical Center , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Department of Radiology , section of Nuclear Medicine, , Leiden, ZA 2333,","place":["the 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Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-127X","authenticated-orcid":false,"given":"Natasha M","family":"Appelman-Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Division of Endocrinology, , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Leiden University Medical Center , Division of Endocrinology, , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Center for Bone Quality, Leiden University Medical Center , Leiden, 2333 ZA,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf M","family":"Dekkers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine , Division of Endocrinology, , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Leiden University Medical Center , Division of Endocrinology, , Leiden, 2333 ZA,","place":["the Netherlands"]},{"name":"Department of Clinical 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