{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:10:12Z","timestamp":1764601812648,"version":"3.41.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Helsinki University Hospital Research","award":["TYH2020334"],"award-info":[{"award-number":["TYH2020334"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Primary hyperparathyroidism (PHPT) associated with multiple endocrine neoplasia type 1 (MEN1) impairs bone mineral density and causes osteoporosis already in young patients. We aimed to investigate bone mineral density (BMD) in a contemporary cohort of patients with MEN1-related PHPT after long-term follow-up and compare these results with that of healthy controls. Thirty-five patients with genetically confirmed MEN1 were diagnosed with MEN1 at mean age 28.7\u2009\u00b1\u200913.6\u00a0years. Thirty-two (91.4%) underwent primary parathyroidectomy at mean age 33.3\u2009\u00b1\u200913.7\u00a0years; 12 had undergone at least 2 surgeries with on average 7.3\u2009\u00b1\u20095.9\u00a0years between the operations. BMD was assessed by DXA at the end of mean follow-up, 13.2\u00a0years after the primary parathyroidectomy and compared with that of 35 age- and gender-matched controls. More than 10\u00a0years after the first parathyroidectomy, mean BMD in patients with MEN1 is in the normal range. However, it is still significantly lower compared with healthy controls.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae129","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T18:56:33Z","timestamp":1729623393000},"source":"Crossref","is-referenced-by-count":3,"title":["Bone mineral density over ten years after primary parathyroidectomy in multiple endocrine neoplasia type 1"],"prefix":"10.1093","volume":"8","author":[{"given":"Emma","family":"Kuusela","sequence":"first","affiliation":[{"name":"Endocrinology , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Helsinki University Hospital and University of Helsinki, ENDO-ERN (European Reference Network on Rare Endocrine Conditions) , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2358-1181","authenticated-orcid":false,"given":"Iiro","family":"Kostiainen","sequence":"additional","affiliation":[{"name":"Endocrinology , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Helsinki University Hospital and University of Helsinki, ENDO-ERN (European Reference Network on Rare Endocrine Conditions) , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Ritvonen","sequence":"additional","affiliation":[{"name":"Endocrinology , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Helsinki University Hospital and University of Helsinki, ENDO-ERN (European Reference Network on Rare Endocrine Conditions) , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Heart and Lung Center , , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Helsinki University Hospital and Helsinki University , , FIN-00290 Helsinki ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5033-6432","authenticated-orcid":false,"given":"Eeva M","family":"Ryh\u00e4nen","sequence":"additional","affiliation":[{"name":"Endocrinology , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Helsinki University Hospital and University of Helsinki, ENDO-ERN (European Reference Network on Rare Endocrine Conditions) , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0161","authenticated-orcid":false,"given":"Camilla","family":"Schalin-J\u00e4ntti","sequence":"additional","affiliation":[{"name":"Endocrinology , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]},{"name":"Helsinki University Hospital and University of Helsinki, ENDO-ERN (European Reference Network on Rare Endocrine Conditions) , Abdominal Center, , FIN-00290 Helsinki ,","place":["Finland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"issue":"4","key":"2024112110465073000_ref1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41574-021-00468-3","article-title":"Clinical aspects of multiple endocrine neoplasia type 1","volume":"17","author":"Al-Salameh","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"8","key":"2024112110465073000_ref2","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3390\/cells10081895","article-title":"Bone and mineral metabolism phenotypes in MEN1-related and sporadic primary hyperparathyroidism, before and after 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