{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:35:45Z","timestamp":1777293345887,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>OI, or bone brittle disease, is characterized by increased mineralization of bone matrix independently of clinical severity. So, a beneficial effect of antiresorptive treatments such as bisphosphonates (BP) is questionable. We aim to compare the bone matrix characteristics before and after BP pamidronate (PAM). Fifty-eight children (9\u2009\u00b1\u20095\u00a0yr-old) with OI (Type I, III, IV, V, VI, XI, or unknown) received intravenous PAM for 2\u00a0yr and underwent transiliac bone biopsies before (n\u2009=\u200957) and after (n\u2009=\u200935) treatment. Compared with age-matched controls, untreated OI was characterized by cortical and cancellous rarefaction. Two years of PAM in OI patients significantly decreased bone remodeling activity, increased cortical thickness, improved the maturation of both organic and mineral matrix, and most of the nanomechanical properties, despite further increase in the degree of mineralization. Overall, in addition to a gain in bone mass, our results showed for the first time that PAM is able to increase the maturation of mineral crystals and collagen matrix contributing to its antifracture efficacy in OI patients.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae161","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T21:14:40Z","timestamp":1733951680000},"source":"Crossref","is-referenced-by-count":3,"title":["Improvement of bone properties in children with osteogenesis imperfecta after pamidronate: a bone biopsy study"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6487-0337","authenticated-orcid":false,"given":"Delphine","family":"Farlay","sequence":"first","affiliation":[{"name":"INSERM UMR 1033, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1 , F-69008 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Cornier","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1 , F-69008 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Rizzo","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1 , F-69008 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-9856","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Cormier-Daire","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics and Reference Centre for Constitutional Bone Diseases, INSERM U1163, Universit\u00e9 de Paris , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maelle","family":"Charpi\u00e9","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics and Reference Centre for Constitutional Bone Diseases, INSERM U1163, Universit\u00e9 de Paris , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziella","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Necker-Enfants Malades Hospital , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hina","family":"Simonnet","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Physique et de R\u00e9adaptation p\u00e9diatrique H\u00f4pital Armand-Trousseau , F-75012 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Badoud","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospital , CH-1211 Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maude","family":"Gerbaix","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Department of Internal Medicine Specialties, Geneva University Hospital , CH-1211 Geneva ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-7361","authenticated-orcid":false,"given":"Pascale","family":"Chavassieux","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1 , F-69008 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"INSERM UMR 1033, Univ Lyon, Universit\u00e9 Claude Bernard Lyon 1 , F-69008 Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"issue":"9","key":"2025012714212222100_ref1","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrendo.2011.81","article-title":"New perspectives on osteogenesis imperfecta","volume":"7","author":"Forlino","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"2025012714212222100_ref2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J Med Genet"},{"issue":"1","key":"2025012714212222100_ref3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40348-020-00101-9","article-title":"Osteogenesis imperfecta-pathophysiology and therapeutic options","volume":"7","author":"Etich","year":"2020","journal-title":"Mol Cell Pediatr"},{"issue":"5","key":"2025012714212222100_ref4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jbmr.5650060512","article-title":"Osteogenesis imperfecta: changes in noncollagenous proteins in bone","volume":"6","author":"Vetter","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2025012714212222100_ref5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s00223-007-9045-x","article-title":"Abnormal mineral-matrix interactions are a significant contributor to fragility in oim\/oim bone","volume":"81","author":"Miller","year":"2007","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"2025012714212222100_ref6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0945-053X(94)90200-3","article-title":"Ultrastructural studies of bones from patients with osteogenesis imperfecta","volume":"14","author":"Traub","year":"1994","journal-title":"Matrix Biol"},{"key":"2025012714212222100_ref7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.bone.2014.04.030","article-title":"Mechanical and mineral properties of osteogenesis imperfecta human bones at the tissue level","volume":"65","author":"Imbert","year":"2014","journal-title":"Bone"},{"issue":"9","key":"2025012714212222100_ref8","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1210\/jc.2016-1334","article-title":"Non-lethal type VIII osteogenesis imperfecta has elevated bone matrix mineralization","volume":"101","author":"Fratzl-Zelman","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2025012714212222100_ref9","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00223-008-9113-x","article-title":"Evidence that abnormal high bone mineralization in growing children with osteogenesis imperfecta is not associated with specific collagen mutations","volume":"82","author":"Roschger","year":"2008","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"2025012714212222100_ref10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s002239900600","article-title":"The mineralization density of iliac crest bone from children with osteogenesis imperfecta","volume":"64","author":"Boyde","year":"1999","journal-title":"Calcif Tissue Int"},{"issue":"1-4","key":"2025012714212222100_ref11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/03008209609029199","article-title":"Mineral changes in a mouse model of osteogenesis imperfecta detected by Fourier transform infrared microscopy","volume":"35","author":"Camacho","year":"1996","journal-title":"Connect Tissue Res"},{"key":"2025012714212222100_ref12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bone.2014.12.023","article-title":"Unique micro- and nano-scale mineralization pattern of human osteogenesis imperfecta type VI bone","volume":"73","author":"Fratzl-Zelman","year":"2015","journal-title":"Bone"},{"issue":"6","key":"2025012714212222100_ref13","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.bone.2012.03.007","article-title":"Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice","volume":"50","author":"Vanleene","year":"2012","journal-title":"Bone"},{"issue":"sup1","key":"2025012714212222100_ref14","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3109\/03008207.2014.923860","article-title":"Multi-scale analysis of bone chemistry, morphology and mechanics in the oim model of osteogenesis imperfecta","volume":"55","author":"Bart","year":"2014","journal-title":"Connect Tissue Res"},{"issue":"6","key":"2025012714212222100_ref15","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/jbmr.2172","article-title":"How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone","volume":"29","author":"Carriero","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2025012714212222100_ref16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2362.1995.tb01706.x","article-title":"Hydroxylation of collagen type I: evidence that both lysyl and prolyl residues are overhydroxylated in osteogenesis imperfecta","volume":"25","author":"Lehmann","year":"1995","journal-title":"Eur J Clin Investig"},{"issue":"2","key":"2025012714212222100_ref17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ajmg.1320450219","article-title":"Possible role of overglycosylation in the type I collagen triple helical domain in the molecular pathogenesis of osteogenesis imperfecta","volume":"45","author":"Tenni","year":"1993","journal-title":"Am J Med Genet"},{"issue":"1","key":"2025012714212222100_ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1302\/1863-2548.13.180190","article-title":"Current concepts in osteogenesis imperfecta: bone structure, biomechanics and medical management","volume":"13","author":"Nijhuis","year":"2019","journal-title":"J Child Orthop"},{"issue":"2","key":"2025012714212222100_ref19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI118428","article-title":"Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering","volume":"97","author":"Fratzl","year":"1996","journal-title":"J Clin Invest"},{"issue":"5","key":"2025012714212222100_ref20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S8756-3282(01)00594-4","article-title":"Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)","volume":"29","author":"Grabner","year":"2001","journal-title":"Bone"},{"key":"2025012714212222100_ref21","doi-asserted-by":"publisher","first-page":"104377","DOI":"10.1016\/j.jmbbm.2021.104377","article-title":"Intrafibrillar mineralization deficiency and osteogenesis imperfecta mouse bone fragility","volume":"117","author":"Maghsoudi-Ganjeh","year":"2021","journal-title":"J Mech Behav Biomed Mater"},{"issue":"6","key":"2025012714212222100_ref22","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00198-009-0861-x","article-title":"Influence of remodeling on the mineralization of bone tissue","volume":"20","author":"Boivin","year":"2009","journal-title":"Osteoporos Int"},{"issue":"4","key":"2025012714212222100_ref23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jbspin.2004.08.011","article-title":"Benefits of pamidronate in children with osteogenesis imperfecta: an open prospective study","volume":"72","author":"Forin","year":"2005","journal-title":"Joint Bone Spine"},{"issue":"3","key":"2025012714212222100_ref24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bone.2006.02.071","article-title":"Pamidronate does not adversely affect bone intrinsic material properties in children with osteogenesis imperfecta","volume":"39","author":"Weber","year":"2006","journal-title":"Bone"},{"issue":"1","key":"2025012714212222100_ref25","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2025012714212222100_ref26","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1172\/JCI111096","article-title":"Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss","volume":"72","author":"Parfitt","year":"1983","journal-title":"J Clin Invest"},{"issue":"2","key":"2025012714212222100_ref27","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3233\/XST-150481","article-title":"Validation of a novel microradiography device for characterization of bone mineralization","volume":"23","author":"Montagner","year":"2015","journal-title":"J Xray Sci Technol"},{"key":"2025012714212222100_ref28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4131029","article-title":"Automation of the peak fitting method in bone FTIR microspectroscopy spectrum analysis: human and mice bone study","volume":"2018","author":"Gardegaront","year":"2018","journal-title":"J Spectrosc"},{"key":"2025012714212222100_ref29","doi-asserted-by":"publisher","first-page":"101623","DOI":"10.1016\/j.bonr.2022.101623","article-title":"Material and nanomechanical properties of bone structural units of cortical and trabecular iliac bone tissues from untreated postmenopausal osteoporotic women","volume":"17","author":"Farlay","year":"2022","journal-title":"Bone Rep"},{"issue":"2","key":"2025012714212222100_ref30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S8756-3282(99)00257-4","article-title":"Normative data for iliac bone histomorphometry in growing children","volume":"26","author":"Glorieux","year":"2000","journal-title":"Bone"},{"issue":"17","key":"2025012714212222100_ref31","doi-asserted-by":"crossref","first-page":"9928","DOI":"10.3390\/ijms23179928","article-title":"Biomechanical, microstructural and material properties of tendon and bone in the young oim mice model of osteogenesis imperfecta","volume":"23","author":"Chretien","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2025012714212222100_ref32","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1172\/JCI0215952","article-title":"The effects of intravenous pamidronate on the bone tissue of children and adolescents with osteogenesis imperfecta","volume":"110","author":"Rauch","year":"2002","journal-title":"J Clin Invest"},{"issue":"1","key":"2025012714212222100_ref33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/(SICI)1097-4636(199904)45:1&lt;48::AID-JBM7&gt;3.0.CO;2-5","article-title":"Elastic properties of microstructural components of human bone tissue as measured by nanoindentation","volume":"45","author":"Rho","year":"1999","journal-title":"J Biomed Mater Res"},{"issue":"10","key":"2025012714212222100_ref34","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0021-9290(99)00111-6","article-title":"Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur","volume":"32","author":"Zysset","year":"1999","journal-title":"J Biomech"},{"issue":"2","key":"2025012714212222100_ref35","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.jbiomech.2013.11.022","article-title":"The effect of hydration on mechanical anisotropy, topography and fibril organization of the osteonal lamellae","volume":"47","author":"Faingold","year":"2014","journal-title":"J Biomech"},{"issue":"9","key":"2025012714212222100_ref36","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1359\/jbmr.070607","article-title":"Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength","volume":"22","author":"Ammann","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2025012714212222100_ref37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF02556213","article-title":"Changes in apatite crystal size in bones of patients with osteogenesis imperfecta","volume":"49","author":"Vetter","year":"1991","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"2025012714212222100_ref38","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jbmr.5650080203","article-title":"Collagen crosslinks and mineral crystallinity in bone of patients with osteogenesis imperfecta","volume":"8","author":"Vetter","year":"1993","journal-title":"J Bone Miner Res"},{"key":"2025012714212222100_ref39","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.bone.2013.11.023","article-title":"Mineral particle size in children with osteogenesis imperfecta type I is not increased independently of specific collagen mutations","volume":"60","author":"Fratzl-Zelman","year":"2014","journal-title":"Bone"},{"issue":"8","key":"2025012714212222100_ref40","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1007\/s00198-012-2228-y","article-title":"Bone mineralization: from tissue to crystal in normal and pathological contexts","volume":"24","author":"Bala","year":"2013","journal-title":"Osteoporos Int"},{"issue":"6","key":"2025012714212222100_ref41","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S8756-3282(00)00269-6","article-title":"Static and dynamic bone histomorphometry in children with osteogenesis imperfecta","volume":"26","author":"Rauch","year":"2000","journal-title":"Bone"},{"issue":"29","key":"2025012714212222100_ref42","doi-asserted-by":"publisher","first-page":"295102","DOI":"10.1088\/0957-4484\/18\/29\/295102","article-title":"Molecular nanomechanics of nascent bone: fibrillar toughening by mineralization","volume":"18","author":"Buehler","year":"2007","journal-title":"Nanotechnology"},{"issue":"4","key":"2025012714212222100_ref43","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/jbmr.2835","article-title":"Bone material properties in osteogenesis imperfecta","volume":"31","author":"Bishop","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"5-6","key":"2025012714212222100_ref44","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s10354-021-00818-w","article-title":"Bone properties in osteogenesis imperfecta: what can we learn from a bone biopsy beyond histology?","volume":"171","author":"M\u00e4hr","year":"2021","journal-title":"Wien Med Wochenschr"},{"issue":"24","key":"2025012714212222100_ref45","doi-asserted-by":"publisher","first-page":"eaba4171","DOI":"10.1126\/sciadv.aba4171","article-title":"Mapping the 3D orientation of nanocrystals and nanostructures in human bone: indications of novel structural features","volume":"6","author":"Gr\u00fcnewald","year":"2020","journal-title":"Sci Adv"},{"issue":"6","key":"2025012714212222100_ref46","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1177\/00220345010800061501","article-title":"Intrafibrillar mineral may be absent in dentinogenesis imperfecta type II (DI-II)","volume":"80","author":"Kinney","year":"2001","journal-title":"J Dent Res"},{"issue":"5","key":"2025012714212222100_ref47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/8756-3282(95)00076-P","article-title":"The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix","volume":"16","author":"Landis","year":"1995","journal-title":"Bone"},{"key":"2025012714212222100_ref48","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jmbbm.2013.03.020","article-title":"Intrafibrillar plasticity through mineral\/collagen sliding is the dominant mechanism for the extreme toughness of antler bone","volume":"28","author":"Gupta","year":"2013","journal-title":"J Mech Behav Biomed Mater"},{"key":"2025012714212222100_ref49","doi-asserted-by":"publisher","first-page":"116580","DOI":"10.1016\/j.bone.2022.116580","article-title":"Accelerated mineralization kinetics in children with osteogenesis imperfecta type 1","volume":"166","author":"Misof","year":"2023","journal-title":"Bone"},{"issue":"1","key":"2025012714212222100_ref50","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/10255842.2011.607444","article-title":"Interaction of microstructure and microcrack growth in cortical bone: a finite element study","volume":"16","author":"Mischinski","year":"2013","journal-title":"Comput Methods Biomech Biomed Engin"}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbmrplus\/advance-article-pdf\/doi\/10.1093\/jbmrpl\/ziae161\/61039065\/ziae161.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article-pdf\/9\/2\/ziae161\/61039065\/ziae161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article-pdf\/9\/2\/ziae161\/61039065\/ziae161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:21:48Z","timestamp":1737987708000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/doi\/10.1093\/jbmrpl\/ziae161\/7921112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/jbmrpl\/ziae161","relation":{},"ISSN":["2473-4039"],"issn-type":[{"value":"2473-4039","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2024,12,11]]},"article-number":"ziae161"}}