{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:30:32Z","timestamp":1792672232369,"version":"4.5.0"},"reference-count":145,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R03DE028411"],"award-info":[{"award-number":["R03DE028411"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE032334"],"award-info":[{"award-number":["R01DE032334"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypophosphatasia (HPP) is an inherited error in metabolism resulting from loss-of-function variants in the ALPL gene, which encodes tissue-nonspecific alkaline phosphatase (TNAP). TNAP plays a crucial role in biomineralization of bones and teeth, in part by reducing levels of inorganic pyrophosphate (PPi), an inhibitor of biomineralization. HPP onset in childhood contributes to rickets, including growth plate defects and impaired growth. In adulthood, osteomalacia from HPP contributes to increased fracture risk. HPP also affects oral health. The dentoalveolar complex, that is, the tooth and supporting connective tissues of the surrounding periodontia, include 4 unique hard tissues: enamel, dentin, cementum, and alveolar bone, and all can be affected by HPP. Premature tooth loss of fully rooted teeth is pathognomonic for HPP. Patients with HPP often have complex oral health issues that require multidisciplinary dental care, potentially involving general or pediatric dentists, periodontists, prosthodontists, and orthodontists. The scientific literature to date has relatively few reports on dental care of individuals with HPP. Animal models to study HPP included global Alpl knockout mice, Alpl mutation knock-in mice, and mice with tissue-specific conditional Alpl ablation, allowing for new studies on pathological mechanisms and treatment effects in dental and skeletal tissues. Enzyme replacement therapy (ERT) in the form of injected, recombinant mineralized tissue-targeted TNAP has been available for nearly a decade and changed the prognosis for those with HPP. However, effects of ERT on dental tissues remain poorly defined and limitations of the current ERT have prompted exploration of gene therapy approaches to treat HPP. Preclinical gene therapy studies are promising and may contribute to improved oral health in HPP.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziae180","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T23:24:42Z","timestamp":1735687482000},"source":"Crossref","is-referenced-by-count":17,"title":["Dental manifestations of hypophosphatasia: translational and clinical advances"],"prefix":"10.1093","volume":"9","author":[{"given":"Elis J","family":"Lira dos Santos","sequence":"first","affiliation":[{"name":"Division of Biosciences, College of Dentistry, The Ohio State University , Columbus, OH , 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma F","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Division of Biosciences, College of Dentistry, The Ohio State University , Columbus, OH , 43210,","place":["United States"]},{"name":"Department of Biologic and Materials Sciences and Prosthodontics, School of Dentistry, University of Michigan , Ann Arbor, MI , 48109,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitrin","family":"Kramer","sequence":"additional","affiliation":[{"name":"Cleft Palate-Craniofacial Clinic , Nationwide Children's Hospital, Columbus, OH , 43205,","place":["United States"]},{"name":"Division of Orthodontics, College of Dentistry, The Ohio State University , Columbus, OH , 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-0576","authenticated-orcid":false,"given":"Brian L","family":"Foster","sequence":"additional","affiliation":[{"name":"Division of Biosciences, College of Dentistry, The Ohio State University , Columbus, OH , 43210,","place":["United 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