{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:02:51Z","timestamp":1787508171904,"version":"build-2736575974"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/100013220","name":"Ultragenyx","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>X-linked hypophosphatemia (XLH) is a rare inherited disorder characterized by elevated levels of FGF23, chronic hypophosphatemia, impaired bone mineralization, and chronic long-term manifestations. Treatment for XLH has been mainly focused on normalizing its biochemical abnormalities. Despite treatment, patients with XLH often present impaired physical function and decreased quality of life (QoL). We hypothesize that physical functionality and QoL are more strongly associated with chronic pain and decreased muscle mass than persistent biochemical abnormalities or exposure to conventional treatment. We conducted an observational, cross-sectional study with patients with XLH. Clinical records and biochemical parameters were assessed. QoL surveys SF36v.2 and WOMAC were applied. Functional status was measured by a physiatrist and an occupational therapist. Appendicular lean mass (ALM) was measured and compared with age and sex-matched healthy controls. Enthesopathies and osteoarthritis were evaluated. Pain was assessed using the Brief Pain Inventory, the Visual Analog Scale, and the Doleur Neuropathique-4 scales. Muscle strength was evaluated by the quadriceps muscle isometric strength (QMS) and physical performance with the 6-Minute Walk Test (6MWT) and the Functional Independence Measure (FIM) scale. A total of 30 patients were included: 21 females; median age of 32\u00a0yr. All participants had significant functional deficits, chronic pain, and reduced QoL. Limitations in daily activities were significantly associated with higher severity of pain, decreased ALM, lower QMS, and less distance in 6MWT (p\u00a0&amp;lt;\u2009.05). Neither FIM scale, phosphate levels, FGF23, nor the lifetime exposure to conventional treatment was associated with these functional variables. In conclusion, impaired physical functionality in patients with XLH was associated with lower muscle mass, lower muscle strength, and severe chronic pain. These findings highlight the importance of, in addition to optimizing the biochemical control of the disease, expanding patient care including pain prevention and management as well as comprehensive physical therapy and rehabilitation.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziaf018","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T23:19:56Z","timestamp":1738279196000},"source":"Crossref","is-referenced-by-count":2,"title":["Factors associated with impaired physical functionality in X-linked hypophosphatemia"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9238-1204","authenticated-orcid":false,"given":"Danisa","family":"Ivanovic-Zuvic","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital del Salvador , Santiago , 7500922,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Madison","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago, 8330023,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9309-9147","authenticated-orcid":false,"given":"Macarena","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile , Santiago, 8330023,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L","family":"Oyanadel","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Pontificia Universidad Cat\u00f3lica de Chile , Santiago, 8330023,","place":["Chile"]},{"name":"Department of Physical Medicine and Rehabilitation, San Borja Arriar\u00e1n Hospital , Santiago , 8360160,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gattini","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Hospital Cl\u00ednico Universidad de Chile , Santiago , 8380000,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Pontificia Universidad Cat\u00f3lica de Chile , Santiago, 8330023,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Cifr\u00e9","sequence":"additional","affiliation":[{"name":"Biomechanics Unit, Innovation Center, Cl\u00ednica MEDS , Santiago , 7550557,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Biomechanics Unit, Innovation 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