{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:12:25Z","timestamp":1766139145308,"version":"3.41.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"AgNovos Bioscience"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this study, QCT was used to analyze the AGN1 Local Osteo-Enhancement Procedure (LOEP) as a treatment to form bone in the proximal femurs of patients with osteoporosis. Using this minimally invasive procedure, a resorbable triphasic AGN1 implant material was injected into the left femurs of 12 women with post-menopausal osteoporosis. Computed tomography scans were taken before treatment (baseline) and at 12\u00a0wk, 24\u00a0wk, and 5-7\u00a0yr after treatment. Quantitative computed tomography was used to investigate the resorption of AGN1 within the treated proximal femurs and to analyze the treatment\u2019s impact on integral, trabecular, and cortical bone. The untreated right femurs were used as controls. Data illustrated an increase in trabecular volumetric BMD (trab vBMD) of treated hips at all timepoints (baseline: 22\u2009\u00b1\u200921\u00a0mg\/cm3 vs 217\u2009\u00b1\u200956\u00a0mg\/cm3, 161\u2009\u00b1\u200918\u00a0mg\/cm3, and 121\u2009\u00b1\u200937\u00a0mg\/cm3 at 12-wk, 24-wk, and 5- to 7-yr timepoints, respectively), and an increase in integral vBMD of 65% at the 12-wk timepoint and 34% at the 5- to 7-yr timepoint. The increase in trab vBMD was observed in the location where the AGN1 implant material bolus was injected, and at the 5- to 7-yr timepoint, no significant BMD change was observed in the trabecular regions surrounding the original implantation zone (treated: 32\u2009\u00b1\u200916\u00a0mg\/cm3, control: 31\u2009\u00b1\u200916\u00a0mg\/cm3). This QCT study provides a more detailed understanding of the resorption and transformation of the AGN1 implant material into bone and supports, with some limitations, that the AGN1 LOEP treatment can locally increase trabecular bone density in weakened areas of the proximal femur where strength increase is most needed to reduce the risk of hip fragility fracture.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziaf036","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T21:54:03Z","timestamp":1743803643000},"source":"Crossref","is-referenced-by-count":1,"title":["AGN1 local osteo-enhancement procedure increases proximal femur volumetric bone mineral density of women with post-menopausal osteoporosis as assessed by quantitative computed tomography analysis"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2003-4388","authenticated-orcid":false,"given":"Michelle","family":"Chin","sequence":"first","affiliation":[{"name":"AgNovos Healthcare , Rockville, MD 20855,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Hill","sequence":"additional","affiliation":[{"name":"AgNovos Healthcare , Rockville, MD 20855,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-4926","authenticated-orcid":false,"given":"Bryan","family":"Huber","sequence":"additional","affiliation":[{"name":"AgNovos Healthcare , Rockville, MD 20855,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Howe","sequence":"additional","affiliation":[{"name":"AgNovos Healthcare , Rockville, MD 20855,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Engelke","sequence":"additional","affiliation":[{"name":"Department of Medical Physics (IMP) , Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg (FAU), Henkestr. 91, 91052, Erlangen,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"issue":"1","key":"2025042806561454900_ref1","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","author":"Sozen","year":"2017","journal-title":"Eur J Rheumatol"},{"issue":"8","key":"2025042806561454900_ref2","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1002\/jbmr.2888","article-title":"A crisis in the treatment of osteoporosis","volume":"31","author":"Khosla","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2025042806561454900_ref3","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/jbmr.3074","article-title":"Addressing the crisis in the treatment of osteoporosis: a path forward","volume":"32","author":"Khosla","year":"2017","journal-title":"J Bone Miner 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and all-cause mortality","volume":"38","author":"Sing","year":"2023","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2025042806561454900_ref8","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11657-016-0292-1","article-title":"Unmet needs and current and future approaches for osteoporotic patients at high risk of hip fracture","volume":"11","author":"Ferrari","year":"2016","journal-title":"Arch Osteoporos"},{"issue":"1","key":"2025042806561454900_ref9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.57582\/IJBF.220201.016","article-title":"Osteo-enhancement procedures in hip fracture prevention: definition and local interventions","volume":"2","author":"Guido","year":"2022","journal-title":"Int J Bone Fragility"},{"key":"2025042806561454900_ref10","doi-asserted-by":"publisher","first-page":"116246","DOI":"10.1016\/j.bone.2021.116246","article-title":"AGN1 implant material to treat bone loss: resorbable implant forms normal bone with and without alendronate in a canine critical size humeral defect model","volume":"154","author":"Shaul","year":"2021","journal-title":"Bone"},{"issue":"5","key":"2025042806561454900_ref11","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s00198-019-05230-0","article-title":"Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study","volume":"31","author":"Howe","year":"2020","journal-title":"Osteoporos Int"},{"issue":"3","key":"2025042806561454900_ref12","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00198-015-3324-6","article-title":"QCT of the proximal femur\u2014which parameters should be measured to discriminate hip fracture?","volume":"27","author":"Museyko","year":"2016","journal-title":"Osteoporos 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