{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:43:47Z","timestamp":1790045027747,"version":"4.0.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2019-01295"],"award-info":[{"award-number":["2019-01295"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","award":["190165"],"award-info":[{"award-number":["190165"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tartrate-resistant acid phosphatase (TRAP) is an enzyme predominantly expressed in osteoclasts, where it plays a pivotal role in bone remodeling. Deficiency in TRAP leads to severe skeletal impairments such as osteopetrosis in humans and mice. While mechanical loading is known to promote bone mass and growth, the role of TRAP in this adaptive process remains unclear. Here, we applied axial tibial loading and micro-CT analysis to investigate differences in anabolic response to mechanical loading in 16-wk-old male TRAP KO (TRAP\u2212\/\u2212) and WT littermate control mice. In WT mice, mechanical loading enhanced the tibial periosteally enclosed area, trabecular bone volume fraction, trabecular thickness, and trabecular number, indicating a robust anabolic response to mechanical strain. In contrast, TRAP\u2212\/\u2212 mice failed to increase cortical bone and displayed markedly reduced trabecular bone formation under the same loading conditions. Analysis of epiphyseal growth plate bony bridges revealed that the number of bridges in lateral tibiae was reduced in TRAP\u2212\/\u2212 mice compared to that in WT control mice following mechanical loading, signifying an impaired mechanoadaptive response. Serum alkaline phosphatase concentrations in TRAP\u2212\/\u2212 mice were similar to those in WT controls, indicating that the inability to respond to mechanical load in TRAP\u2212\/\u2212 mice is due to TRAP\u2019s specific role in the bone\u2019s adaptive responses to mechanical loading, possibly involving partially impaired osteoblastic bone formation. These findings highlight TRAP as a mediator of bone adaptation to mechanical loading. Understanding the functions of TRAP in mechanoadaptation could direct therapeutic strategies aimed at improving bone strength and treating conditions associated with TRAP dysfunction.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziaf073","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:32:20Z","timestamp":1745418740000},"source":"Crossref","is-referenced-by-count":3,"title":["Tartrate-resistant acid phosphatase augments the bone anabolic response to mechanical loading in male mice"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-0468","authenticated-orcid":false,"given":"Bhavik","family":"Rathod","sequence":"first","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet , 141 52 Huddinge ,","place":["Sweden"]},{"name":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet , National Pandemic Center, Stockholm, 17165 Solna,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasmik Jasmine","family":"Samvelyan","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical Technology Research Centre, The Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University , CM1 1SQ Chelmsford ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchita","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet , 141 52 Huddinge ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bock","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet , 141 52 Huddinge 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Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Sahlgrenska Academy at The University of Gothenburg , 413 46 Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2123-7838","authenticated-orcid":false,"given":"Per","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Division of Clinical Chemistry, Department of Biomedical and Clinical Sciences, Link\u00f6ping University , 581 85 Link\u00f6ping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Andersson","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet , 141 52 Huddinge ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara 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