{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:38Z","timestamp":1787009078469,"version":"build-2736575974"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Canada Research Chair in Biomineralization","award":["R01DE032334"],"award-info":[{"award-number":["R01DE032334"]}]},{"name":"Canada Research Chair in Biomineralization","award":["P01AG081167"],"award-info":[{"award-number":["P01AG081167"]}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs program","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Quebec FRQ-S McGill University Centre for Structural Biology Research"},{"name":"Quebec FRQ-S Network for Intersectorial Research in Sustainable Oral and Bone Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>X-linked hypophosphatemia (XLH) is caused by inactivating mutations in PHEX, leading to disturbed mineral metabolism, rickets, and osteomalacia. Dentoalveolar defects affecting dentin, cementum, and alveolar bone, contribute to dental abscesses and periodontal breakdown. Limited efficacy of current therapies for ameliorating XLH-associated dentoalveolar effects suggests mechanisms of disease that remain unchecked. Increased production and abnormal distribution of osteopontin (OPN) is thought to contribute to XLH-associated mineralization defects. Osteopontin is a secreted phosphoprotein and mineralization inhibitor, and a substrate of PHEX. To investigate the potential role of OPN in the pathology of XLH-associated dentoalveolar defects, a genetic approach was used to ablate or diminish Spp1\/OPN in the Hyp mouse model of XLH. One or both Spp1 alleles in Hyp mice were deleted and tissues were analyzed at 60\u00a0d postnatally (dpn). Micro-CT showed no differences in volumes or densities of dentin and alveolar bone in Hyp mice lacking one or both Spp1 alleles, as compared to control Hyp mice. Histological assessment showed no improvements in cementum or periodontal ligament attachment, and dynamic mechanical analysis revealed no normalization of periodontal mechanical properties. While OPN may play a role in regulating dentoalveolar mineralization, diminishing OPN alone was not sufficient to substantially ameliorate XLH-associated defects.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziaf170","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:03:58Z","timestamp":1761393838000},"source":"Crossref","is-referenced-by-count":2,"title":["Genetic reduction or deletion of osteopontin in osteomalacic\n                    <i>Hyp<\/i>\n                    mice fails to ameliorate dentoalveolar defects"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1848-0335","authenticated-orcid":false,"given":"Aonjittra","family":"Phanrungsuwan","sequence":"first","affiliation":[{"name":"Division of Biosciences , College of Dentistry, The Ohio State University, Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bella","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Division of Biosciences , College of Dentistry, The Ohio State University, Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinju","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, College of Dentistry, The Ohio State University , Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Sweet","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, College of Dentistry, The Ohio State University , Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-6694","authenticated-orcid":false,"given":"Flavia Amadeu","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Sanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Gyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Orthodontics, College of Dentistry, The Ohio State University , Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-6916","authenticated-orcid":false,"given":"Eva S","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-2671","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Sanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute , La Jolla, CA 92037,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-965X","authenticated-orcid":false,"given":"Marc D","family":"McKee","sequence":"additional","affiliation":[{"name":"Faculty of Dental Medicine and Oral Health Sciences, McGill University , Montreal, QC H3A 0C7 ,","place":["Canada"]},{"name":"Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, School of Biomedical Sciences, McGill University , Montreal, QC H3A 0C7 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3444-0576","authenticated-orcid":false,"given":"Brian L","family":"Foster","sequence":"additional","affiliation":[{"name":"Division of Biosciences , College of Dentistry, The Ohio State University, Columbus, OH 43210,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"issue":"1","key":"2025112411164923300_ref1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11154-017-9408-1","article-title":"X-linked hypophosphatemia and growth","volume":"18","author":"Fuente","year":"2017","journal-title":"Rev Endocr Metab Disord"},{"issue":"2","key":"2025112411164923300_ref2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/ng1095-130","article-title":"A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. 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