{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:00:05Z","timestamp":1790146805998,"version":"4.0.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction: Discontinuation of denosumab can lead to a rebound increase in bone resorption, which may result in multiple vertebral fractures. Current guidelines recommend retreatment with denosumab or administration of zoledronate in this setting. Materials and methods: We report a series of 4 patients who developed vertebral fractures following denosumab withdrawal and were subsequently treated with romosozumab, a dual-action agent with anabolic and antiresorptive properties. Results: All patients showed progressive improvement in BMD and microarchitecture, with suppression of bone turnover markers and no new clinical fractures during treatment and follow-up. Discussion: Although limited by the uncontrolled design and small sample size, these observations suggest that romosozumab might be considered as a potential therapeutic approach for selected patients with post-denosumab rebound fractures.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziaf186","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T13:00:53Z","timestamp":1765026053000},"source":"Crossref","is-referenced-by-count":1,"title":["Romosozumab after rebound vertebral fractures induced by denosumab discontinuation: a case series"],"prefix":"10.1093","volume":"10","author":[{"given":"Marcelo","family":"Sarli","sequence":"first","affiliation":[{"name":"Department of Endocrinology, IDIM, \u00a0 Buenos Aires , C1012AAR,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanina","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IDIM, \u00a0 Buenos Aires , C1012AAR,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Abdala","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IDIM, \u00a0 Buenos Aires , C1012AAR,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Armanelli","sequence":"additional","affiliation":[{"name":"Department of Bone and Mineral Metabolism, Facultad de Medicina, Universidad del Salvador , Buenos Aires , C1055AAG,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia","family":"Bocci","sequence":"additional","affiliation":[{"name":"Department of Bone and Mineral Metabolism, Facultad de Medicina, Universidad del Salvador , Buenos Aires , C1055AAG,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Jerkovich","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IDIM, \u00a0 Buenos Aires , C1012AAR,","place":["Argentina"]},{"name":"Department of Endocrinology, Hospital General de Agudos Dr. Juan A. Fern\u00e1ndez , Buenos Aires , C1425AGP,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-1847","authenticated-orcid":false,"given":"Mar\u00eda Bel\u00e9n","family":"Zanchetta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, IDIM, \u00a0 Buenos Aires , C1012AAR,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"8","key":"2026012703122587900_ref1","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med"},{"issue":"1","key":"2026012703122587900_ref2","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3390\/jcm10010152","article-title":"Denosumab discontinuation and the rebound phenomenon: a narrative review","volume":"10","author":"Anastasilakis","year":"2021","journal-title":"J Clin Med"},{"issue":"1","key":"2026012703122587900_ref3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1210\/clinem\/dgaa756","article-title":"Fracture risk and management of discontinuation of denosumab therapy: a systematic review and position statement by ECTS","volume":"106","author":"Tsourdi","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2026012703122587900_ref4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1002\/jcph.239","article-title":"Multiple doses of sclerostin antibody romosozumab in healthy men and postmenopausal women with low bone mass: a randomized, double-blind, placebo-controlled study","volume":"54","author":"Padhi","year":"2014","journal-title":"J Clin Pharmacol"},{"issue":"2","key":"2026012703122587900_ref5","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/jbmr\/zjae179","article-title":"Romosozumab following denosumab improves lumbar spine bone mineral density and trabecular bone score greater than denosumab continuation in postmenopausal women","volume":"40","author":"Hong","year":"2025","journal-title":"J Bone Miner Res"},{"key":"2026012703122587900_ref6","doi-asserted-by":"publisher","first-page":"100288","DOI":"10.1016\/j.bonr.2020.100288","article-title":"Romosozumab was not effective in preventing multiple spontaneous clinical vertebral fractures after denosumab discontinuation: a case report","volume":"13","author":"Kashii","year":"2020","journal-title":"Bone Rep"},{"issue":"5","key":"2026012703122587900_ref7","doi-asserted-by":"publisher","first-page":"105754","DOI":"10.1016\/j.jbspin.2024.105754","article-title":"Progression of multiple vertebral fractures after denosumab discontinuation under treatment with romosozumab. 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