{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:32:27Z","timestamp":1788888747105,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A650188"],"award-info":[{"award-number":["N42A650188"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Faculty of Pharmaceutical Sciences, Chulalongkorn University","award":["Phar2567_RG006"],"award-info":[{"award-number":["Phar2567_RG006"]}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cannabidiol (CBD) effects on bone metabolism in postmenopausal osteoporosis remain unclear. While endocannabinoids and phytocannabinoids bind to receptors in bone cells, direct evidence of CBD\u2019s bone-protective effects is lacking. We evaluated the effects of CBD on bone metabolism in ovariectomized (OVX) rat model of estrogen deficiency. Twelve-week study with treatment initiated 2\u00a0wk after the surgery was conducted. Five experimental groups were established: sham-operated with vehicle (SHM\/VEH), sham with CBD (SHM\/CBD5), OVX with vehicle (OVX\/VEH), OVX with 17\u03b2-estradiol (OVX\/E2), and OVX with CBD (OVX\/CBD5). Cannabidiol was administered at 5\u00a0mg\/kg\/d via osmotic pumps. Micro-CT of the distal femur revealed that trabecular bone mass in OVX\/CBD5 decreased similarly to OVX\/VEH, indicating no protective effect. Serum bone turnover markers showed increased bone resorption in OVX\/CBD5 compared to OVX\/VEH. Gene expression analysis revealed that estrogen significantly reduced Ctsk gene expression compared to OVX\/VEH, while CBD showed no significant differences. No significant changes were observed in cannabinoid receptor expression or bone metabolism in sham-operated rats receiving CBD. While CBD (5\u00a0mg\/kg\/d) was well-tolerated, it did not mitigate OVX-induced bone loss in skeletally mature rats. Consequently, CBD should not be considered a monotherapy for postmenopausal osteoporosis, though it appears safe for other potential medical applications.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziaf197","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T12:43:56Z","timestamp":1767098636000},"source":"Crossref","is-referenced-by-count":1,"title":["Long-term cannabidiol treatment did not restore bone microstructural defects in skeletally mature ovariectomized Sprague-Dawley rats"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0308-1690","authenticated-orcid":false,"given":"Krittikan","family":"Chanpaisaeng","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University , Bangkok 10330 ,","place":["Thailand"]},{"name":"Food Biotechnology Research Team, National Center for Genetic Engineering and Biotechnology , Pathum Thani 12120 ,","place":["Thailand"]},{"name":"Center of Excellence for Preclinical Toxicity and Efficacy Assessment of Medicines and Chemicals, Chulalongkorn University , Bangkok 10330 ,","place":["Thailand"]},{"name":"Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol University , Bangkok 10400 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C","family":"Fleet","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Texas , Austin, TX 78712 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visut","family":"Rawiwet","sequence":"additional","affiliation":[{"name":"Central Animal Facility, Faculty of Science, Mahidol University , Bangkok 10400 ,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthaporn","family":"Phonsatta","sequence":"additional","affiliation":[{"name":"Food Biotechnology Research Team, 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Bangkok 10400 ,","place":["Thailand"]},{"name":"Department of Physiology, Faculty of Science, Mahidol University , Bangkok 10400 ,","place":["Thailand"]},{"name":"Institute of Molecular Biosciences, Mahidol University , Nakhon Pathom 73170 ,","place":["Thailand"]},{"name":"The Academy of Science, The Royal Society of Thailand , Bangkok 10210,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"2026012703123907400_ref1","volume-title":"Bone Health and Osteoporosis: a Report of the Surgeon General","author":"Office of the Surgeon General (US)","year":"2004"},{"key":"2026012703123907400_ref2","volume-title":"World Population Prospects 2022: Summary of Results","author":"United Nations Department of Economic and Social Affairs PD","year":"2022"},{"key":"2026012703123907400_ref3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bone.2017.01.024","article-title":"The 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