{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T20:29:00Z","timestamp":1769545740024,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["#R01DE029850"],"award-info":[{"award-number":["#R01DE029850"]}]},{"name":"National Institute of Health","award":["#R35 DE034346"],"award-info":[{"award-number":["#R35 DE034346"]}]},{"name":"National Institute of Health","award":["#R01DE025222-05S2"],"award-info":[{"award-number":["#R01DE025222-05S2"]}]},{"name":"National Institute of Health","award":["#R01AR083445"],"award-info":[{"award-number":["#R01AR083445"]}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["EDUC4-12756"],"award-info":[{"award-number":["EDUC4-12756"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Temporomandibular joint disorders (TMDs) are a group of clinical conditions characterized by chronic jaw dysfunction and persistent orofacial pain, affecting approximately one-third of the adult population. Anterior displacement of the articular disc (ADD), which leads to joint instability and mechanical overload, is strongly linked to arthrogenous TMD. However, the cellular and molecular mechanisms triggered by ADD, and how they contribute to joint derangement, remain poorly understood. Clinical treatments for this chronic condition are also limited. Although several animal models exist for ADD, most are difficult to validate and rely on species that lack advanced genetic tools. To address this, we developed a reproducible and compatible surgical murine model of ADD, which is suitable for lineage tracing, reporter analyses, and gene modification techniques. Here, we describe a procedure for generating unilateral surgical ADD in adult mice and validate this model using MRI. Whole-mount skeletal staining and histology reveal degeneration of the condylar cartilage, erosion of the temporal bone, and disc fibrosis by 15\u00a0d post-surgery (dps), compared to controls. Overall, this genetically tractable murine model offers a powerful platform for dissecting the mechanisms of ADD and identifying new cellular and molecular targets for TMD therapy.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag002","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:36:01Z","timestamp":1768566961000},"source":"Crossref","is-referenced-by-count":0,"title":["A reproducible mouse model of TMJ anterior disc displacement"],"prefix":"10.1093","volume":"10","author":[{"given":"Maria","family":"Pacheco-Vergara","sequence":"first","affiliation":[{"name":"Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Gioia","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Ko","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi S","family":"Sta Maria","sequence":"additional","affiliation":[{"name":"Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]},{"name":"Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-8763","authenticated-orcid":false,"given":"Francesca V","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-1575","authenticated-orcid":false,"given":"Amy E","family":"Merrill","sequence":"additional","affiliation":[{"name":"Center for Craniofacial Molecular Biology, Department of Biomedical Sciences, Herman Ostrow School of Dentistry, University of Southern California , Los Angeles, CA 90033 ,","place":["United States"]},{"name":"Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033 ,","place":["United 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Paper commissioned by the Committee on Temporomandibular Disorders (TMDs): From research discoveries to clinical treatment in temporomandibular disorders: Priorities for Research and Care (see Appendix C)","author":"Slade","year":"2020"},{"issue":"7","key":"2026012703121066500_ref12","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1111\/odi.14266","article-title":"Temporomandibular joint osteoarthritis: a review of animal models induced by surgical interventions","volume":"29","author":"Zhou","year":"2023","journal-title":"Oral Dis"},{"issue":"1","key":"2026012703121066500_ref13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.2334\/josnusd.19-0093","article-title":"A rat model for inducing temporomandibular anterior disc displacement experimentally","volume":"62","author":"Nguyen","year":"2020","journal-title":"J Oral Sci"},{"issue":"11","key":"2026012703121066500_ref14","first-page":"3806","article-title":"Characterization of a rat model with temporomandibular 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