{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:07:05Z","timestamp":1772446025872,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["18-CE14-0018-01"],"award-info":[{"award-number":["18-CE14-0018-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DGE20111123012"],"award-info":[{"award-number":["DGE20111123012"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["SPF202209015771"],"award-info":[{"award-number":["SPF202209015771"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Endocrinologie et de Diab\u00e9tologie P\u00e9diatrique"},{"name":"French Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>X-linked hypophosphatemia (XLH), the most common form of genetic rickets (1\/20000 births), results in the disruption of skeletal and dental mineralization. Oral features include dentinomalacia, spontaneous dental abscesses, and a high susceptibility to periodontitis. The association of phosphate supplementation and active vitamin D analogs (PO4\/VitD) aims to counteract the consequences of FGF23 excess and the impaired production of active vitamin D. Despite a significant improvement in the long bone phenotype, the impact on dentoalveolar tissues remains poorly documented. Here, we aimed to determine whether the PO4\/VitD treatment improves dental features in the Hyp mouse model of XLH and in XLH patients. Hyp mice were treated with oral phosphate supplementation and calcitriol injections from 3 wk to 3 mo and were compared with untreated Hyp and WT mice. Histological analyses were also performed on teeth from patients with XLH treated with PO4\/VitD and on control teeth. Micro-CT analyses showed that the PO4\/VitD treatment did not significantly correct dentin\/cementum volume and density, pulp chamber enlargement, and alveolar bone parameters in Hyp mice. Histological analyses also revealed that dentinomalacia and periodontal attachment were not rescued by the treatment. Remarkably, permanent teeth from XLH patients treated with PO4\/VitD during childhood displayed a significant reduction in predentin thickness and a thinner layer of globular dentin. Taken together, our data show that the PO4\/VitD treatment does not significantly improve dentoalveolar features in Hyp mice treated at the prepubertal stage. However, the impact observed on dentin in human teeth supports the interest of this treatment regarding the occurrence of spontaneous dental abscesses.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag011","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T12:41:15Z","timestamp":1769258475000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of oral phosphate supplements and active vitamin D treatment on dentoalveolar features of X-linked hypophosphatemia"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6811-8318","authenticated-orcid":false,"given":"Julien","family":"Po","sequence":"first","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]},{"name":"Service de M\u00e9decine Bucco-dentaire, AP-HP, H\u00f4pital Louis-Mourier , F-92700 Colombes ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis J","family":"Lira dos Santos","sequence":"additional","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axelle","family":"Cauliez","sequence":"additional","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volha V","family":"Zhukouskaya","sequence":"additional","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-002X","authenticated-orcid":false,"given":"Agnes","family":"Linglart","sequence":"additional","affiliation":[{"name":"Inserm U1185, AP-HP, DMU SEA, Endocrinology and Diabetes for Children, Reference Center for Rare Diseases of the Calcium and Phosphate Metabolism, OSCAR fili\u00e8re, EndoRare, and BOND ERN, Bic\u00eatre Hospital, Paris-Saclay University , F-94270 Le Kremlin-Bic\u00eatre ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3463-3936","authenticated-orcid":false,"given":"Catherine","family":"Chaussain","sequence":"additional","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]},{"name":"AP-HP, Reference Center for Rare Disorders of the Calcium and Phosphate Metabolism, Dental Medicine Department, Bretonneau Hospital, GHN-Universit\u00e9 Paris Cit\u00e9 , F-75018 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Bardet","sequence":"additional","affiliation":[{"name":"Inserm, Sant\u00e9 Orale, Universit\u00e9 Paris Cit\u00e9 and Sorbonne Paris Nord , F-92120 Montrouge ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"issue":"5","key":"2026030204262817600_ref1","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/s41581-024-00926-x","article-title":"Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia","volume":"21","author":"Haffner","year":"2025","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"2026030204262817600_ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13023-019-1014-8","article-title":"FGF23 and its role in X-linked hypophosphatemia-related morbidity","volume":"14","author":"Beck-Nielsen","year":"2019","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"2026030204262817600_ref3","doi-asserted-by":"publisher","first-page":"R13","DOI":"10.1530\/EC-13-0103","article-title":"Therapeutic management of hypophosphatemic rickets from infancy to adulthood","volume":"3","author":"Linglart","year":"2014","journal-title":"Endocr Connect"},{"issue":"4","key":"2026030204262817600_ref4","first-page":"531","article-title":"Dental problems in hypophosphatemic rickets, a cross sectional study","volume":"22","author":"Rabbani","year":"2012","journal-title":"Iran J Pediatr"},{"issue":"1","key":"2026030204262817600_ref5","doi-asserted-by":"crossref","first-page":"e210564","DOI":"10.1530\/EC-21-0564","article-title":"Oral health-related quality of life in patients with X-linked hypophosphatemia: a qualitative exploration","volume":"11","author":"Nguyen","year":"2022","journal-title":"Endocr Connect"},{"issue":"3","key":"2026030204262817600_ref6","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1067\/mpd.2003.119","article-title":"Dental abnormalities in patients with familial hypophosphatemic vitamin D-resistant rickets: prevention by early treatment with 1-hydroxyvitamin D","volume":"142","author":"Chaussain-Miller","year":"2003","journal-title":"J Pediatr"},{"key":"2026030204262817600_ref7","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.bone.2017.07.026","article-title":"Tissue-specific mineralization defects in the periodontium of the Hyp mouse model of X-linked hypophosphatemia","volume":"103","author":"Coyac","year":"2017","journal-title":"Bone"},{"issue":"2","key":"2026030204262817600_ref8","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/jbmr.1767","article-title":"Tooth root dentin mineralization defects in a mouse model of hypophosphatasia","volume":"28","author":"Foster","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2026030204262817600_ref9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00467-005-2077-4","article-title":"Hypophosphatemic rickets: results of a long-term follow-up","volume":"21","author":"Vaisbich","year":"2006","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"2026030204262817600_ref10","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1210\/JC.2015-2199","article-title":"Conventional therapy in adults with X-linked hypophosphatemia: effects on enthesopathy and dental disease","volume":"100","author":"Connor","year":"2015","journal-title":"J Clin 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