{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:52:09Z","timestamp":1793033529298,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union within the Horizon Europe MSCA program","award":["101072766"],"award-info":[{"award-number":["101072766"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["CRC1149"],"award-info":[{"award-number":["CRC1149"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["251293561"],"award-info":[{"award-number":["251293561"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["ZJ-L"],"award-info":[{"award-number":["ZJ-L"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["JE 642\/4-2"],"award-info":[{"award-number":["JE 642\/4-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["277277765"],"award-info":[{"award-number":["277277765"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["FOR2407"],"award-info":[{"award-number":["FOR2407"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Catecholamines are known to interact with bone and cartilage cells via binding to adrenergic receptors. Among these, the \u03b22-adrenoceptor (\u03b22-AR) plays a key role in mediating the effects of catecholamines on bone. Mice lacking the \u03b22-AR systemically or specifically in osteoblasts show an increased bone mass. Previous studies further indicated an important influence of catecholamines on transdifferentiation of chondrocytes towards osteoblasts during endochondral ossification. Therefore, in this study, cartilage and bone phenotype as well as fracture healing of mice with a specific knockout of the \u03b22-AR in chondrocytes were investigated. Tibiae and femora of 6-, 12-, and 40-wk-old male and female mice were analyzed. The knockout resulted in a reduced long bone growth, most likely due to a faster transition of proliferative to hypertrophic chondrocytes. The older knockout mice additionally showed an osteopenic bone phenotype due to a reduced number of osteoblasts. Fracture healing after a standardized femur osteotomy was delayed, showing reduced cartilage area at an intermediate time point during fracture healing. Gene expression analysis in an additional in-vitro-experiment identified pathways like \u201cWnt-signaling\u201d and \u201cTGF\u03b2-signaling\u201d to be involved. In conclusion, our data showed an important role of the \u03b22-AR specifically in chondrocytes during long bone growth, bone homeostasis in older animals and fracture healing.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag021","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:48:00Z","timestamp":1770900480000},"source":"Crossref","is-referenced-by-count":4,"title":["\u03b22-adrenoceptor signaling in chondrocytes regulates long bone growth, bone homeostasis, and fracture healing in mice"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9016-5873","authenticated-orcid":false,"given":"Melanie Rebecca","family":"Kuhn","sequence":"first","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]},{"name":"Department of Orthopedic Trauma, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-2613","authenticated-orcid":false,"given":"Melanie","family":"Haffner-Luntzer","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8043-4283","authenticated-orcid":false,"given":"Sandra","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Sachs","sequence":"additional","affiliation":[{"name":"Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Department of Trauma Surgery and Orthopedics, Goethe University Frankfurt, University Hospital , 60528 Frankfurt\/Main ,","place":["Hessen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9095-3950","authenticated-orcid":false,"given":"Gundula","family":"R\u00f6sch","sequence":"additional","affiliation":[{"name":"Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Department of Trauma Surgery and Orthopedics, Goethe University Frankfurt, University Hospital , 60528 Frankfurt\/Main ,","place":["Hessen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-2523","authenticated-orcid":false,"given":"Zsuzsa","family":"Jenei-Lanzl","sequence":"additional","affiliation":[{"name":"Dr. Rolf M. Schwiete Research Unit for Osteoarthritis, Department of Trauma Surgery and Orthopedics, Goethe University Frankfurt, University Hospital , 60528 Frankfurt\/Main ,","place":["Hessen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan Oskar","family":"Reber","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4782-1979","authenticated-orcid":false,"given":"Anita","family":"Ignatius","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6409-9340","authenticated-orcid":false,"given":"Miriam Eva Angelica","family":"Tschaffon-M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Orthopedic Research and Biomechanics, University Medical Center , 89081 Ulm, Baden-W\u00fcrttemberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"issue":"Suppl 3","key":"2026030916362489000_ref1","doi-asserted-by":"publisher","first-page":"S131","DOI":"10.2215\/CJN.04151206","article-title":"Normal bone anatomy and physiology","volume":"3 Suppl 3","author":"Clarke","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"7","key":"2026030916362489000_ref2","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1182\/blood-2004-06-2480","article-title":"Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche","volume":"105","author":"Taichman","year":"2005","journal-title":"Blood."},{"issue":"8","key":"2026030916362489000_ref3","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.3382\/ps.0701806","article-title":"The role of the growth plate in longitudinal bone growth","volume":"70","author":"Pines","year":"1991","journal-title":"Poult Sci"},{"key":"2026030916362489000_ref4","doi-asserted-by":"publisher","first-page":"421746","DOI":"10.1155\/2015\/421746","article-title":"Biology of bone tissue: structure, function, and factors that influence bone cells","volume":"2015","author":"Florencio-Silva","year":"2015","journal-title":"Biomed Res Int"},{"issue":"1","key":"2026030916362489000_ref5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41572-021-00289-8","article-title":"Non-union bone fractures","volume":"7","author":"Wildemann","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"2026030916362489000_ref6","doi-asserted-by":"publisher","first-page":"115607","DOI":"10.1016\/j.bone.2020.115607","article-title":"Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma","volume":"142","author":"Yokomoto-Umakoshi","year":"2021","journal-title":"Bone."},{"issue":"17","key":"2026030916362489000_ref7","doi-asserted-by":"publisher","first-page":"8615","DOI":"10.1073\/pnas.1819218116","article-title":"Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via beta-AR signaling","volume":"116","author":"Haffner-Luntzer","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2026030916362489000_ref8","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.1038\/s41467-023-38616-0","article-title":"Neutrophil-derived catecholamines mediate negative stress effects on bone","volume":"14","author":"Tschaffon-Muller","year":"2023","journal-title":"Nat Commun"},{"key":"2026030916362489000_ref9","doi-asserted-by":"publisher","first-page":"997745","DOI":"10.3389\/fendo.2022.997745","article-title":"Myeloid cell-derived catecholamines influence bone turnover and regeneration in mice","volume":"13","author":"Kuhn","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1-2","key":"2026030916362489000_ref10","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.abb.2008.11.012","article-title":"Beta2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms","volume":"482","author":"Aitken","year":"2009","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"2026030916362489000_ref11","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jcp.21761","article-title":"Functional alpha1- and beta2-adrenergic receptors in human osteoblasts","volume":"220","author":"Huang","year":"2009","journal-title":"J Cell Physiol"},{"issue":"3","key":"2026030916362489000_ref12","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.bone.2009.05.004","article-title":"Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members","volume":"45","author":"Takarada","year":"2009","journal-title":"Bone."},{"issue":"3","key":"2026030916362489000_ref13","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/art.33449","article-title":"Substance P and norepinephrine modulate murine chondrocyte proliferation and apoptosis","volume":"64","author":"Opolka","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"2","key":"2026030916362489000_ref14","first-page":"94","article-title":"Adrenergic control of bone remodeling and its implications for the treatment of osteoporosis","volume":"8","author":"Bonnet","year":"2008","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"9","key":"2026030916362489000_ref15","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1517\/13543784.17.9.1281","article-title":"The effect of beta-blockers on bone metabolism as potential drugs under investigation for osteoporosis and fracture healing","volume":"17","author":"Graham","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"issue":"7032","key":"2026030916362489000_ref16","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature."},{"issue":"3","key":"2026030916362489000_ref17","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/s0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell."},{"issue":"4","key":"2026030916362489000_ref18","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1084\/jem.20102608","article-title":"Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual","volume":"208","author":"Kajimura","year":"2011","journal-title":"J Exp Med"},{"issue":"743","key":"2026030916362489000_ref19","doi-asserted-by":"publisher","first-page":"eadk9129","DOI":"10.1126\/scitranslmed.adk9129","article-title":"Increased beta(2)-adrenergic signaling promotes fracture healing through callus neovascularization in mice","volume":"16","author":"Jahn","year":"2024","journal-title":"Sci Transl Med"},{"issue":"7","key":"2026030916362489000_ref20","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1083\/jcb.200809113","article-title":"The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity","volume":"183","author":"Hinoi","year":"2008","journal-title":"J Cell Biol"},{"issue":"2","key":"2026030916362489000_ref21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<145::AID-GENE14>3.0.CO;2-C","article-title":"Col2a1-directed expression of Cre recombinase in differentiating chondrocytes in transgenic mice","volume":"26","author":"Ovchinnikov","year":"2000","journal-title":"Genesis."},{"issue":"6","key":"2026030916362489000_ref22","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol"},{"issue":"11","key":"2026030916362489000_ref23","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1002\/jor.21148","article-title":"Fracture healing in mice under controlled rigid and flexible conditions using an adjustable external fixator","volume":"28","author":"Rontgen","year":"2010","journal-title":"J Orthop Res"},{"issue":"7","key":"2026030916362489000_ref24","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2026030916362489000_ref25","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1002\/jbmr.4797","article-title":"Wnt1 boosts fracture healing by enhancing bone formation in the fracture callus","volume":"38","author":"Haffner-Luntzer","year":"2023","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2026030916362489000_ref26","doi-asserted-by":"publisher","first-page":"e23489","DOI":"10.1096\/fj.202301424RR","article-title":"Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via plat","volume":"38","author":"Ahmad","year":"2024","journal-title":"FASEB J"},{"issue":"2","key":"2026030916362489000_ref27","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/jcb.21646","article-title":"Beta2-adrenergic receptors expressed on murine chondrocytes stimulate cellular growth and inhibit the expression of Indian hedgehog and collagen type X","volume":"104","author":"Lai","year":"2008","journal-title":"J Cell Biochem"},{"issue":"3","key":"2026030916362489000_ref28","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s11914-020-00570-x","article-title":"The actions of IGF-1 in the growth plate and its role in postnatal bone elongation","volume":"18","author":"Racine","year":"2020","journal-title":"Curr Osteoporos Rep"},{"issue":"3","key":"2026030916362489000_ref29","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1152\/physiolgenomics.00022.2007","article-title":"Disruption of insulin-like growth factor-I expression in type IIalphaI collagen-expressing cells reduces bone length and width in mice","volume":"30","author":"Govoni","year":"2007","journal-title":"Physiol Genomics"},{"issue":"2","key":"2026030916362489000_ref30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.yexcr.2004.11.012","article-title":"Cell responses to FGFR3 signalling: growth, differentiation and apoptosis","volume":"304","author":"L'Hote","year":"2005","journal-title":"Exp Cell Res"},{"issue":"2","key":"2026030916362489000_ref31","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","article-title":"Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia","volume":"78","author":"Shiang","year":"1994","journal-title":"Cell."},{"issue":"4","key":"2026030916362489000_ref32","doi-asserted-by":"publisher","first-page":"E633","DOI":"10.1152\/ajpendo.00515.2010","article-title":"\u03b22-adrenergic receptors inhibit the expression of collagen type II in growth plate chondrocytes by stimulating the AP-1 factor Jun-B","volume":"300","author":"Mitchell","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"2026030916362489000_ref33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052902","article-title":"Bone mass and osteoblast activity are sex-dependent in mice lacking the Estrogen receptor alpha in chondrocytes and osteoblast progenitor cells","volume":"23","author":"Steppe","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"15","key":"2026030916362489000_ref34","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154280","article-title":"Sex\/gender- and age-related differences in beta-adrenergic receptor Signaling in cardiovascular diseases","volume":"11","author":"Liccardo","year":"2022","journal-title":"J Clin Med"},{"issue":"3","key":"2026030916362489000_ref35","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1254\/fpj.145.140","article-title":"Regulation of bone metabolism by sympathetic nervous system","volume":"145","author":"Togari","year":"2015","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"33","key":"2026030916362489000_ref36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302703111","article-title":"Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation","volume":"111","author":"Yang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"2026030916362489000_ref37","doi-asserted-by":"publisher","first-page":"e1004820","DOI":"10.1371\/journal.pgen.1004820","article-title":"Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice","volume":"10","author":"Zhou","year":"2014","journal-title":"PLoS Genet"},{"issue":"1","key":"2026030916362489000_ref38","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41413-024-00342-8","article-title":"Wnt\/beta-catenin signaling components and mechanisms in bone formation, homeostasis, and disease","volume":"12","author":"Hu","year":"2024","journal-title":"Bone Res"},{"issue":"1","key":"2026030916362489000_ref39","doi-asserted-by":"publisher","first-page":"e1009233","DOI":"10.1371\/journal.pgen.1009233","article-title":"Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways","volume":"17","author":"Tang","year":"2021","journal-title":"PLoS Genet"},{"issue":"13","key":"2026030916362489000_ref40","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1042\/BCJ20200036","article-title":"Runx1 up-regulates chondrocyte to osteoblast lineage commitment and promotes bone formation by enhancing both chondrogenesis and osteogenesis","volume":"477","author":"Tang","year":"2020","journal-title":"Biochem J"},{"key":"2026030916362489000_ref41","doi-asserted-by":"publisher","first-page":"16009","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-beta and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res"},{"issue":"Pt 3","key":"2026030916362489000_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00407.x","article-title":"Human ageing and the sympathoadrenal system","volume":"528","author":"Seals","year":"2000","journal-title":"J Physiol"},{"issue":"6","key":"2026030916362489000_ref43","doi-asserted-by":"publisher","first-page":"e10496","DOI":"10.1002\/jbm4.10496","article-title":"Single-cell RNA-sequencing reveals the breadth of osteoblast heterogeneity","volume":"5","author":"Yoshioka","year":"2021","journal-title":"JBMR Plus"},{"key":"2026030916362489000_ref44","doi-asserted-by":"publisher","first-page":"730095","DOI":"10.3389\/fcell.2021.730095","article-title":"Connective tissue growth factor from periosteal tartrate acid phosphatase-positive monocytes direct skeletal stem cell renewal and fate during bone healing","volume":"9","author":"Bai","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"2026030916362489000_ref45","doi-asserted-by":"publisher","first-page":"e1150","DOI":"10.1371\/journal.pone.0001150","article-title":"Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration","volume":"2","author":"Behonick","year":"2007","journal-title":"PLoS One"},{"issue":"17","key":"2026030916362489000_ref46","doi-asserted-by":"publisher","first-page":"4123","DOI":"10.1242\/dev.00559","article-title":"Altered fracture repair in the absence of MMP9","volume":"130","author":"Colnot","year":"2003","journal-title":"Development."}],"container-title":["JBMR Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbmrplus\/advance-article-pdf\/doi\/10.1093\/jbmrpl\/ziag021\/66901554\/ziag021.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article-pdf\/10\/4\/ziag021\/66901554\/ziag021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article-pdf\/10\/4\/ziag021\/66901554\/ziag021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:36:33Z","timestamp":1773088593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmrplus\/article\/doi\/10.1093\/jbmrpl\/ziag021\/8483865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2,28]]}},"URL":"https:\/\/doi.org\/10.1093\/jbmrpl\/ziag021","relation":{},"ISSN":["2473-4039"],"issn-type":[{"value":"2473-4039","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,4]]},"published":{"date-parts":[[2026,2,14]]},"article-number":"ziag021"}}