{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:04:18Z","timestamp":1776780258317,"version":"3.51.2"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Osteoporotic Fractures in Men"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG027810"],"award-info":[{"award-number":["U01 AG027810"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042124"],"award-info":[{"award-number":["U01 AG042124"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042139"],"award-info":[{"award-number":["U01 AG042139"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042140"],"award-info":[{"award-number":["U01 AG042140"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042143"],"award-info":[{"award-number":["U01 AG042143"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042145"],"award-info":[{"award-number":["U01 AG042145"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AG042168"],"award-info":[{"award-number":["U01 AG042168"]}]},{"name":"NIH Roadmap for Medical Research","award":["U01 AR066160"],"award-info":[{"award-number":["U01 AR066160"]}]},{"name":"NIH Roadmap for Medical Research","award":["R01 AG066671"],"award-info":[{"award-number":["R01 AG066671"]}]},{"name":"NIH Roadmap for Medical Research","award":["UL1 TR000128"],"award-info":[{"award-number":["UL1 TR000128"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The vitamin D metabolite ratio (VMR), calculated as the ratio of 24,25(OH)2D3 to 25(OH)D, is a marker of vitamin D stores that may provide a more accurate reflection of bone health outcomes than 25(OH)D alone. In this analysis, we examined the relationship between VMR and 25(OH)D with bone turnover markers (BTM\u2019s) and changes in volumetric BMD (Tt.BMD) in older community-dwelling men participating in the Osteoporotic Fractures in Men (MrOS) study. Tt.BMD was measured at the distal radius and tibia by HR-pQCT at 2 separate visits approximately 6\u00a0yr apart. Bone turnover markers were measured at the time of the first HR-pQCT scan and included PTH, C-terminal telopeptide of type I collagen (CTX-I), and N-terminal propeptide of type I procollagen (PINP). Linear regression was used to evaluate the association of VMR and 25(OH)D with BTM\u2019s and annualized percent change in Tt.BMD. The mean (SD) age of the 254 men was 83(3)\u00a0yr, with an eGFR of 71(14) mL\/min\/1.73\u00a0m2. Mean VMR and 25(OH)D were 6.5(2.2) (ng\/mL)\/(ng\/mL) and 39(14) ng\/mL, respectively. Both the VMR and 25(OH)D were inversely associated with PTH concentrations (p\u2009&amp;lt;\u2009.02 for both). In fully adjusted models, a 2-fold higher VMR was associated with a 34% [12%; 55%] lower CTX-I and a 16% [1.3%;30%] lower PINP while 25(OH)D was not associated with these BTMs. The relationship of VMR with BTM\u2019s appeared stronger among men with CKD (eGFR &amp;lt;60\u00a0mL\/min\/1.73\u00a0m2) than in persons with normal renal function. Neither VMR nor 25(OH)D were associated with annualized change in Tt.BMD in fully adjusted models.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag044","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:57:59Z","timestamp":1773838679000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of the vitamin D metabolite ratio with bone turnover markers and changes in volumetric BMD"],"prefix":"10.1093","volume":"10","author":[{"given":"Emma","family":"Mulligan","sequence":"first","affiliation":[{"name":"Division of Nephrology-Hypertension, University of California, San Diego , San Diego, CA 92093 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri","family":"Blackwell","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center Research Institute and Department of Epidemiology and Biostatistics, University of California San Francisco , San Fransisco, CA 94143 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-0243","authenticated-orcid":false,"given":"Andrew N","family":"Hoofnagle","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Pathology and Medicine and the Kidney Research Institute, University of Washington , Seattle, WA 98104 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia Alison","family":"Potok","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, University of California, San Diego , San Diego, CA 92093 ,","place":["United States"]},{"name":"Nephrology Section, Veterans Affairs San Diego Healthcare System , San Diego, CA 92161 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-4408","authenticated-orcid":false,"given":"Jane A","family":"Cauley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh , Pittsburgh, PA 15261 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-4944","authenticated-orcid":false,"given":"Andrew J","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California, San Francisco , San Francisco, CA 94143 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-3036","authenticated-orcid":false,"given":"Kristine","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Center for Care Delivery and Outcomes Research, Minneapolis Veterans Affairs Healthcare System , Minneapolis, MN 55417 ,","place":["United States"]},{"name":"Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota , Minneapolis, MN 55455 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-5573","authenticated-orcid":false,"given":"Deborah M","family":"Kado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Stanford University , Palo Alto, CA 94305 ,","place":["United States"]},{"name":"Geriatric Research Education and Clinical Center (GRECC), Veterans Affairs Healthcare System , Palo Alto, CA 94304 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim H","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology-Hypertension, University of California, San Diego , San Diego, CA 92093 ,","place":["United States"]},{"name":"Nephrology Section, Veterans Affairs San Diego Healthcare System , San Diego, CA 92161 ,","place":["United 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