{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T03:04:02Z","timestamp":1780023842036,"version":"3.53.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012807","name":"Midwestern University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Marfan syndrome (MFS), caused by mutations in the Fbn1 gene, is associated with skeletal fragility; yet, the geometric and mechanical consequences for long bones remain underexplored. We examined femoral geometry and rigidity in male and female Fbn1^C1041G\/+ (MFS) and WT C57BL\/6\u00a0J (littermate control) mice (n\u2009=\u20095\/sex\/genotype) at 6 mo of age using high-resolution micro-CT. Femur length, cortical and medullary areas, cross-sectional circularity, and derived rigidity indices (IMAX, IMIN) were quantified across 3 diaphyseal locations. Marfan syndrome mice had significantly longer femora than controls, with more circular cross-sections regardless of sex. Male MFS mice displayed endosteal expansion, reduced cortical bone (\u221218% to 30%), and lower bending rigidity, indicating weakened structural resistance. In contrast, female MFS mice maintained or exceeded control rigidity values despite geometric alterations. These findings reveal pronounced sex-dependent skeletal effects in MFS, suggesting that cortical bone loss and estimated mechanical weakening are male-biased features, potentially linked to hormonal influences and altered bone remodeling. Such differences may contribute to differential fracture risk and have implications for targeted interventions in connective tissue disorders.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag072","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:35:32Z","timestamp":1776339332000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-dependent alterations of the femoral geometry in a mouse model of Marfan syndrome"],"prefix":"10.1093","volume":"10","author":[{"given":"Gina","family":"Agostini-Walesch","sequence":"first","affiliation":[{"name":"College of Dental Medicine, Midwestern University , Glendale, AZ 85308,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Arizona College of Osteopathic Medicine, Midwestern University , Glendale, AZ 85308,","place":["United 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