{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:26:32Z","timestamp":1787023592173,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme under Marie Sk\u0142odowska-Curie Grant","award":["860898"],"award-info":[{"award-number":["860898"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Microvascular diseases (MVD) in type 2 diabetes mellitus (T2D) are associated with alterations in the bone microarchitecture, but their association with fracture risk is unclear. We investigated whether MVD (retinopathy, nephropathy, and neuropathy) are associated with higher fracture risk in persons with T2D.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>We identified 10\u2009491 persons with T2D, enrolled in the Danish Centre for Strategic Research in Type 2 Diabetes cohort between 2010 and 2022. The primary outcomes were any hospital-diagnosed fracture (except facial and cranial), and major osteoporotic fractures (MOF), defined as clinical vertebral, hip, humerus, and forearm fractures, in persons with hospital-diagnosed MVD vs without MVD. We used Cox proportional hazard models to calculate crude and adjusted hazard ratios (aHRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow-up of 7.6\u00a0yr IQR (3.5; 9.7), the rates of any fracture were higher in persons with T2D and MVD vs no MVD (aHR 1.31; 95% CI [1.15; 1.51]). Similarly, MOF rate was elevated in persons with MVD (aHR 1.33 [1.09; 161]). The rates for any fracture and MOF were highest in persons with neuropathy (aHR 1.49 [1.24; 1.78] and aHR 1.54 [1.19; 1.99], respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Fracture risk is elevated in persons with T2D complicated by MVD, particularly in those with neuropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jbmrpl\/ziag102","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T16:34:28Z","timestamp":1781627668000},"source":"Crossref","is-referenced-by-count":0,"title":["Elevated fracture risk in a Danish cohort with type 2 diabetes mellitus and microvascular diseases"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-592X","authenticated-orcid":false,"given":"Mohamad I","family":"Nasser","sequence":"first","affiliation":[{"name":"Department of Endocrinology and 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University Diabetes Center, Lund University , Lund, 221 84 ,","place":["Sweden"]},{"name":"Department of Endocrinology, Sk\u00e5ne University Hospital , Malm\u00f6, 214 28 ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3179-1186","authenticated-orcid":false,"given":"Jens Steen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark , Odense, 5230 ,","place":["Denmark"]},{"name":"Steno Diabetes Center Odense, Odense University Hospital , Odense, 5260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-4224","authenticated-orcid":false,"given":"Kurt","family":"H\u00f8jlund","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark , Odense, 5230 ,","place":["Denmark"]},{"name":"Steno Diabetes Center Odense, Odense University Hospital , Odense, 5260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-5780","authenticated-orcid":false,"given":"Michael H","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Medicine , University of Copenhagen, Copenhagen, 2200 ,","place":["Denmark"]},{"name":"Steno Diabetes Center Zealand , Holbaek, 4300 ,","place":["Denmark"]},{"name":"Department of Regional Health Research, University of Southern Denmark , Odense, 5230 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-2967","authenticated-orcid":false,"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark, Aalborg University Hospital , Aalborg, 9260 ,","place":["Denmark"]},{"name":"Department of Endocrinology, Aalborg University Hospital , Aalborg, 9260 ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aalborg University Hospital , Aalborg, 9260 ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-3366","authenticated-orcid":false,"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Academic Unit of Bone Metabolism, University of Sheffield , Sheffield, S5 7AS ,","place":["United Kingdom"]},{"name":"Mellanby Centre for Musculoskeletal Research, University of Sheffield , Sheffield, S5 7AS ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5608-1589","authenticated-orcid":false,"given":"Morten","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Molecular Endocrinology Laboratory (KMEB), Odense University Hospital , Odense, 5230 ,","place":["Denmark"]},{"name":"Department of Clinical Research, 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