{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:08:15Z","timestamp":1789416495418,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#5R01DK122558"],"award-info":[{"award-number":["#5R01DK122558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The goal of this study is to investigate the causes of skeletal fragility in type 1 diabetic (T1D) women. We hypothesize that bone fragility in diabetic individuals is partly due to changes in mineral and\/or intrinsic material properties in the osteocyte lacunar\/peri-lacunar regions of bone tissue. Studies of bone material properties in T1D are limited, and BMD alone does not explain the elevated fracture risk in T1D women (Cases). Innovative instruments with nanoscale resolution, including a laser scanning microscope, an atomic force microscope that is integrated with infrared spectroscopy, and a nanoindenter, were used for the characterization of the material properties surrounding osteocyte lacunae. In trabecular bone tissue, the compositional Mineral Matrix Area (MMA) and MMP ratios (for both near- &amp; far-lacunae), along with material strength variables (Modulus, Hardness for both near- &amp; far-lacunae), were lower in T1D compared to Controls. While the material compositional ratio of mineral maturity, crystallinity, and area was higher, the mineral maturity, crystallinity peak, and hardness tended to be higher in \u201clacunae-near\u201d than \u201clacunae-far\u201d for all the biopsies. Furthermore, the higher mineral matrix (MMA) and material strength (modulus, hardness) in peri-lacunar regions of Controls may suggest its increased brittleness or differences in properties as compared to T1D. We postulate that the difference between Cases (T1D) and Controls in modulus and hardness could be due to the variation in mineral exchange (diffusion) rate within the perilacunar space.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag139","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:36:03Z","timestamp":1787052963000},"source":"Crossref","is-referenced-by-count":0,"title":["Nanoscale investigation of bone tissue near lacunae of trabecular bone in type-1 diabetic postmenopausal women"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2833-0469","authenticated-orcid":false,"given":"Maxwyll","family":"McConnell","sequence":"first","affiliation":[{"name":"University of Nebraska-Lincoln , Lincoln, NE 68588-0526 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Qian","sequence":"additional","affiliation":[{"name":"University of Nebraska-Lincoln , Lincoln, NE 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NE 68122 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A","family":"Turner","sequence":"additional","affiliation":[{"name":"University of Nebraska-Lincoln , Lincoln, NE 68588-0526 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam A","family":"Dubrow","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center, Creighton University , Omaha, NE 68122 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M","family":"Lappe","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center, Creighton University , Omaha, NE 68122 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Recker","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center, Creighton University , Omaha, NE 68122 ,","place":["United 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