{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:08:17Z","timestamp":1789398497314,"version":"build-2803163510"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bruck syndrome is a rare autosomal recessive form of OI caused by biallelic variants in FKBP10 or PLOD2, and characterized by fragility fractures with congenital or progressive joint contractures. We describe 13 patients from 2 tertiary pediatric centers in the United Arab Emirates and report exploratory health-related quality-of-life data using the Pediatric Quality of Life Inventory (PedsQL). Published molecularly confirmed cases were reviewed solely to contextualize the cohort. The cohort comprised 13 patients (7 female and 6 male; median age, 4\u00a0yr; range, 13 mo-14\u00a0yr) from 11 unrelated families, including 2 sibling pairs. Twelve patients had FKBP10 variants and 1 had PLOD2 variants. FKBP10 c.831dup was identified in 10 patients from 8 unrelated families of Emirati, Sudanese, and Indian backgrounds. Recurrent long-bone fractures occurred in 11 patients (85%), joint contractures in 6 (46%), and vertebral deformity in 9 (69%). Mobility ranged from independent ambulation to nonambulatory status, including among patients carrying c.831dup. The PedsQL domain scores (mean\u2009\u00b1\u2009SD) were 47.2\u2009\u00b1\u200923.7 for physical functioning, 72.7\u2009\u00b1\u200919.3 for emotional functioning, 57.7\u2009\u00b1\u200922.5 for social functioning, and 64.5\u2009\u00b1\u200925.0 for school functioning. Physical functioning had the lowest mean domain score; these findings are descriptive because of the small, age-heterogeneous cohort, and the limitations of a single generic instrument. This 2-center case series expands the reported phenotypic and functional spectrum of FKBP10- and PLOD2-related diseases. The FKBP10 c.831dup variant was identified across 3 national backgrounds in the UAE cohort and has been reported in other populations, supporting its interpretation as a recurrent variant brought into homozygosity by regional consanguinity rather than a UAE-specific founder mutation. The variability in skeletal severity, mobility, and functional outcome, including among patients sharing the same variant, highlights the need for individualized multidisciplinary care addressing fracture prevention, mobility, spinal surveillance, rehabilitation, and long-term function.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag146","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:38:09Z","timestamp":1787657889000},"source":"Crossref","is-referenced-by-count":0,"title":["Phenotypic spectrum and quality of life in pediatric Bruck syndrome due to FKBP10 and PLOD2 variants: a 2-center United Arab Emirates experience"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-6554","authenticated-orcid":false,"given":"Mohammad Hosny","family":"Awad","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology Department, Al Jalila Children\u2019s Specialty Hospital, Dubai Health, P.O. Box 7662 , Dubai ,","place":["United Arab Emirates"]},{"name":"Pediatric Department, Mansoura University, Mansoura 35516 ,","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8830-839X","authenticated-orcid":false,"given":"Rania","family":"Eladl","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department, Al Jalila Children\u2019s Specialty Hospital, Dubai Health, P.O. Box 7662 , Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-1340","authenticated-orcid":false,"given":"Asmahan Tagelsir","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine Division, Sheikh Shakhbout Medical City , P.O. Box 11001, Abu Dhabi ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-4408","authenticated-orcid":false,"given":"Ibrar","family":"Majid","sequence":"additional","affiliation":[{"name":"Orthopedic Department, Al Jalila Children\u2019s Specialty Hospital , Dubai Health, P.O. Box 7662, Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-5694","authenticated-orcid":false,"given":"Mohamed","family":"Kenaway","sequence":"additional","affiliation":[{"name":"Orthopedic Department, Al Jalila Children\u2019s Specialty Hospital , Dubai Health, P.O. Box 7662, Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-7642","authenticated-orcid":false,"given":"Mason","family":"Alnouri","sequence":"additional","affiliation":[{"name":"Orthopedic Department, Al Jalila Children\u2019s Specialty Hospital , Dubai Health, P.O. Box 7662, Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-206X","authenticated-orcid":false,"given":"Sattar","family":"Alshryda","sequence":"additional","affiliation":[{"name":"Orthopedic Department, Al Jalila Children\u2019s Specialty Hospital , Dubai Health, P.O. Box 7662, Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8821-0066","authenticated-orcid":false,"given":"Manal","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department, Al Jalila Children\u2019s Specialty Hospital, Dubai Health, P.O. Box 7662 , Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2890-7515","authenticated-orcid":false,"given":"Sarah","family":"Ehtisham","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department, Al Jalila Children\u2019s Specialty Hospital, Dubai Health, P.O. Box 7662 , Dubai ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4090-4672","authenticated-orcid":false,"given":"Asma","family":"Deeb","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine Division, Sheikh Shakhbout Medical City , P.O. Box 11001, Abu Dhabi ,","place":["United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-5663","authenticated-orcid":false,"given":"Mohamed Zulficar","family":"Mughal","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology Department, Al Jalila Children\u2019s Specialty Hospital, Dubai Health, P.O. 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