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This study describes the impact of bilateral orchiectomy (ORX) in a colony of diet-induced obese (DIO) male Mauritius cynomolgus macaques (DIO-CM) maintained on a Western Style Diet (WSD). Body composition analysis via DXA was performed prior and up to 15\u00a0m postsurgery to determine the long-term changes in hypogonadism. As expected, ORX significantly reduced testosterone, inhibin B, and estrogen while increasing follicle-stimulating hormone and luteinizing hormone throughout the entire follow-up period. Animals lost significant body weight mainly due to a loss of lean but not fat mass. Orchiectomy had detrimental and long-lasting, 15\u00a0m postsurgery, effects on bone, including decreased total BMC and BMD, with the most drastic losses localized to the pelvic region. Additionally, animals demonstrated a transient elevation of numerous bone turnover markers. This model demonstrates that in a phenotypically well-characterized colony of DIO-CM, hypogonadism induces lean mass loss, increased body fat percentage, and numerous hallmarks of osteoporosis. This nonhuman primate model is relevant to human bone biology, age-related body composition changes, such as sarcopenic obesity, and hypogonadism and therefore could be utilized to test muscle and bone mass preserving interventions in the future.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag150","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:57:31Z","timestamp":1788289051000},"source":"Crossref","is-referenced-by-count":0,"title":["Skeletal and body composition effects of orchiectomy in a colony of diet-induced obese cynomolgus macaques"],"prefix":"10.1093","volume":"10","author":[{"given":"Melissa A","family":"Kirigiti","sequence":"first","affiliation":[{"name":"Division of Metabolic Health and Disease, Oregon National Primate Research Center, Oregon Health and Science University , Beaverton, OR 97006 ,","place":["United 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