{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:37:39Z","timestamp":1792823859452,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U01 AR080969"],"award-info":[{"award-number":["U01 AR080969"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"STRONG BONES","award":["R01 AR083706"],"award-info":[{"award-number":["R01 AR083706"]}]},{"name":"Wake Forest University Claude D. 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This pilot study examined association between HR-pQCT-measured leg muscle cross-sectional area (CSA) and density vs DXA-derived lean mass, and explored associations with muscle strength, power, and physical performance in adults with obesity. Patients eligible for bariatric surgery (BMI\u2009\u2265\u200930\u00a0kg\/m2; ages \u226530) received baseline HR-pQCT (XtremeCT II) and DXA (Hologic) scans. HR-pQCT scans of the non-dominant leg were acquired at 30% of tibial length and processed using a custom Python script for muscle segmentation, followed by manual editing. Whole-body DXA scans were analyzed to extract lean mass for the total leg and subregions analogous to the HR-pQCT. Functional measures included gait speed (400-m walk), muscle power (12-step stair climb), and knee extensor strength (isokinetic dynamometer). Pearson correlations assessed relationships between imaging modalities and functional measures. Among 28 adults (ages: 47.7\u2009\u00b1\u20098.6; BMI: 43.8\u2009\u00b1\u20094.6\u00a0kg\/m2), HR-pQCT muscle CSA and density averaged 36.0\u2009\u00b1\u20094.8\u00a0cm2 and 60.1\u2009\u00b1\u20098.1 HU, respectively. DXA lean mass was 2.23\u2009\u00b1\u20090.40\u00a0kg for the total leg and 0.107\u2009\u00b1\u20090.019\u00a0kg for the 30% site. HR-pQCT muscle CSA correlated moderately with DXA lean mass (r\u2009=\u20090.57-0.69, p\u2009=\u2009.0017-&amp;lt;.0001), whereas HR-pQCT muscle density showed negligible correlations with DXA lean mass (r\u2009=\u2009\u22120.01-0.04, p\u2009=\u2009.84-0.96). Significant positive correlations were observed for DXA total leg lean mass with absolute muscle power (r\u2009=\u20090.40) and HR-pQCT muscle CSA with knee strength (r\u2009=\u20090.41; both p\u2009&amp;lt;\u2009.05). In adults with obesity, HR-pQCT and DXA may provide complementary measures of leg muscle quantity, with moderate association for CSA and lean mass, but limited associations with muscle density. Body weight and whole-body lean mass showed stronger correlations with stair climb power (r\u2009=\u20090.42-0.70) than localized leg muscle measures (r\u2009=\u20090.17-0.40). Muscle density and muscle quantity may capture different aspects of musculoskeletal health, warranting further investigation in larger samples.<\/jats:p>","DOI":"10.1093\/jbmrpl\/ziag158","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:38:40Z","timestamp":1790077120000},"source":"Crossref","is-referenced-by-count":0,"title":["Leg muscle assessment by HR-pQCT and DXA: associations between imaging measures and muscle function in adults with obesity\u2014a pilot study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-2824","authenticated-orcid":false,"given":"S\u00f8ren","family":"Gam","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Esbjerg and Grindsted Hospital, University Hospital of Southern Denmark , 6700 Esbjerg ,","place":["Denmark"]},{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark , 5230 Odense M ,","place":["Denmark"]},{"name":"Department of Regional Health Research, University of Southern Denmark , 5230 Odense M ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-1806","authenticated-orcid":false,"given":"Joshua R","family":"Stapleton","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Wake Forest University School of Medicine , Winston-Salem, NC 27101,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3036-4387","authenticated-orcid":false,"given":"Vivian","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Wake Forest University , Winston-Salem, NC 27109 ,","place":["United 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Medicine , Winston-Salem, NC 27101,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9092-0454","authenticated-orcid":false,"given":"Kristin","family":"Cattell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Wake Forest University School of Medicine , Winston-Salem, NC 27101,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1392-4302","authenticated-orcid":false,"given":"Lori S","family":"Cogdill","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Wake Forest University , Winston-Salem, NC 27109 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6396-8698","authenticated-orcid":false,"given":"Catherine","family":"MacLean","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Wake Forest University , Winston-Salem, NC 27109 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-2174","authenticated-orcid":false,"given":"Sherri A","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Wake Forest University , Winston-Salem, NC 27109 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-2563","authenticated-orcid":false,"given":"Marjorie J","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine , Winston-Salem, NC 27157 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4286-9463","authenticated-orcid":false,"given":"Daniel P","family":"Beavers","sequence":"additional","affiliation":[{"name":"Department of Statistical Sciences, Wake Forest University , Winston-Salem, NC 27109 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1643-6795","authenticated-orcid":false,"given":"Jamy D","family":"Ard","sequence":"additional","affiliation":[{"name":"Weight Management Center, Atrium Health Wake Forest Baptist , Winston-Salem, NC 27104 ,","place":["United States"]},{"name":"Department of Epidemiology and Prevention, Wake Forest University School of Medicine , Winston-Salem, NC 27157 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-5997","authenticated-orcid":false,"given":"Steven K","family":"Boyd","sequence":"additional","affiliation":[{"name":"McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary , Calgary , AB T2N 4Z6,","place":["Canada"]},{"name":"Department of Biomedical Engineering, Schulich School of Engineering, University of Calgary , Calgary , AB T2N 4Z6,","place":["Canada"]},{"name":"Department of Radiology, Cumming School of Medicine, University of Calgary , Calgary , AB T2N 4Z6,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4383-0106","authenticated-orcid":false,"given":"Ashley A","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Wake Forest University School of Medicine , Winston-Salem, NC 27101,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-4195","authenticated-orcid":false,"given":"Kristen M","family":"Beavers","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science, Wake Forest University , Winston-Salem, NC 27109 ,","place":["United 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