{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:55:24Z","timestamp":1767707724591,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>A 40% risk of disease recurrence post-liver transplantation (LT) for autoimmune hepatitis (AIH) has been previously reported. Risk factors for recurrence and its impact on long-term patient outcome are poorly defined. We aimed to assess prevalence, time to disease recurrence, as well as patient and graft survival in patients with recurrent AIH (rAIH) versus those without recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Single-center retrospective study of adult recipients who underwent LT for AIH between January 2007 and December 2017. Patients with AIH overlap syndromes were excluded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1436 LTs were performed during the study period, of whom 46 (3%) for AIH. Eight patients had AIH overlap syndromes and were excluded. Patients were followed up for 4.4 \u00b1 3.4 years and mean age at LT was 46.8 years. Average transplant MELD (Model for End-Stage Liver Disease) score was 24.9. About 21% of patients (8 of 38) were transplanted for acute onset of AIH; 66% of patients (n = 25) received a deceased donor liver graft, and 34% a living donor organ. rAIH occurred in 7.8% (n = 3\/38) of recipients. Time to recurrence was 1.6, 12.2 and 60.7 months. Patient and graft survival in patients without recurrence was 88.6% and 82.8% in 5 years, whereas in those with rAIH, it was 66.7%, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Although AIH recurs post-LT, our data indicate a lower recurrence rate when compared to the literature and excellent patient and graft survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jcag\/gwaa022","type":"journal-article","created":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T19:18:34Z","timestamp":1593371914000},"page":"137-144","source":"Crossref","is-referenced-by-count":6,"title":["Single-Center North American Experience of Liver Transplantation in Autoimmune Hepatitis: Infrequent Indication but Good Outcomes for Patients"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-7543","authenticated-orcid":false,"given":"Fernanda","family":"de Quadros Onofrio","sequence":"first","affiliation":[{"name":"Toronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evon","family":"Neong","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Adebayo","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmar","family":"Kollmann","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oyedele Adewale","family":"Adeyi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon Morris","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina Elisabeth","family":"Hansen","sequence":"additional","affiliation":[{"name":"Toronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada"},{"name":"IHPME, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamatha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Galvin","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie Blake","family":"Lilly","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazia","family":"Selzner","sequence":"additional","affiliation":[{"name":"Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"issue":"6","key":"2021052716200256700_CIT0001","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/hep.23584","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"51","author":"Manns","year":"2010","journal-title":"Hepatology"},{"issue":"12","key":"2021052716200256700_CIT0002","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.lts.2003.09.018","article-title":"Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry","volume":"9","author":"Adam","year":"2003","journal-title":"Liver Transpl"},{"issue":"1","key":"2021052716200256700_CIT0003","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/lt.25375","article-title":"Recurrent and de novo autoimmune hepatitis","volume":"25","author":"Stirnimann","year":"2019","journal-title":"Liver 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