{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:38Z","timestamp":1787009078750,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is associated with inflammatory bowel disease (IBD), though risk factors remain to be determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To characterize HS among a cohort of IBD patients and identify risk factors for its development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective case\u2013control study at the ambulatory IBD centre at Mount Sinai Hospital from inception to May 2019. Patients with IBD who developed HS were included. Cases were matched 5:1 by age, gender (male versus female) and IBD type (ulcerative colitis [UC] or Crohn\u2019s disease [CD]) to controls who had IBD without HS. Conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (95% CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-nine cases of HS (19 CD and 10 UC) and 145 controls were included. Of the 29 patients with HS, 11 (37.9%) were male and 18 (62.1%) were female. The severity of HS was mild in 10 (34.5%), moderate in 16 (55.2%) and severe in 3 (10.3%) patients. Patients with HS and IBD were more likely to be active (OR 10.3, 95% CI 2.0 to 54.0, P = 0.006) or past (OR 8.4, 95% CI 2.7 to 25.8, P &amp;lt; 0.005) smokers. Patients with HS and IBD were also more likely to have active endoscopic disease (OR 3.8, 95% CI 1.2 to 12.2, P = 0.022). Furthermore, those with HS and CD were more likely to have active perianal disease (OR 21.1, 95% CI 6.2 to 71.9, P &amp;lt; 0.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Active IBD, perianal disease and smoking may be associated with HS in IBD. Larger studies are needed to better characterize this morbid condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jcag\/gwaa024","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T15:09:32Z","timestamp":1593616172000},"page":"165-172","source":"Crossref","is-referenced-by-count":13,"title":["Risk Factors for Developing Hidradenitis Suppurativa in Patients With Inflammatory Bowel Disease: A Retrospective Case\u2013Control Study"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3192-0910","authenticated-orcid":false,"given":"Parul","family":"Tandon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Govardhanam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zane","family":"Gallinger","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-7925","authenticated-orcid":false,"given":"Adam V","family":"Weizman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"issue":"2","key":"2021072911302687800_CIT0001","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archinte.1988.00380020041008","article-title":"Extraintestinal manifestations of idiopathic inflammatory bowel disease","volume":"148","author":"Danzi","year":"1988","journal-title":"Arch Intern Med"},{"issue":"1","key":"2021072911302687800_CIT0002","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ajg.2010.343","article-title":"Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort","volume":"106","author":"Vavricka","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"2021072911302687800_CIT0003","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphys.2012.00013","article-title":"Skin manifestations of inflammatory bowel disease","volume":"3","author":"Huang","year":"2012","journal-title":"Front Physiol"},{"issue":"1","key":"2021072911302687800_CIT0004","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cgh.2015.04.173","article-title":"Hidradenitis suppurativa in patients with inflammatory bowel disease: A population-based cohort study in Olmsted County, Minnesota","volume":"14","author":"Yadav","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"2021072911302687800_CIT0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cgh.2015.04.180","article-title":"Features of patients with Crohn\u2019s disease and hidradenitis suppurativa","volume":"14","author":"Kamal","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"2021072911302687800_CIT0006","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/bjd.13002","article-title":"The prevalence of hidradenitis suppurativa in 1093 patients with inflammatory bowel disease","volume":"171","author":"van der Zee","year":"2014","journal-title":"Br J Dermatol"},{"issue":"1","key":"2021072911302687800_CIT0007","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1365-2133.2009.09430.x","article-title":"Hidradenitis suppurativa and inflammatory bowel disease: are they associated? 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