{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:11:33Z","timestamp":1788498693971,"version":"build-2803163510"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malnutrition among inflammatory bowel disease (IBD) subjects is well documented in literature and may emerge from factors including inadequate dietary intake, malabsorption and disease activity. The aim of this study was to complete a comprehensive nutrition assessment and explore what possibilities may help bring a better quality of life for IBD subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Nutritional status based on biochemical tests, body composition and body mass index (BMI). Food intake was assessed by an alternate 3-day food record and the adequacy of intake was evaluated according to national and international references. Clinical disease activity was evaluated by the Harvey-Bradshaw index and CRP levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study included 217 patients and 65 controls, where 54.4% of these patients were classified as normal weight with a mean BMI lower than controls (23.8 \u00b1 4.9 versus 26.9 \u00b1 4.8 kg\/m2, P = 0.02). Patients with disease activity showed more overweight and obesity than patients with controlled disease. Vitamin B12 deficiency was present in 19% of Crohn\u2019s disease (CD), mainly in patients with ileal commitment and small bowel resections. Anemia was present in 21.7% of patients, being more common in patients with active disease (25%) and bowel resection (23%). Regarding calorie intake (EI), CD group ingested more than controls (1986.3 \u00b1 595.9 kcal versus 1701.8 \u00b1 478.9 kcal; P = 0.003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CD patients presented micronutrient deficiency when compared with controls, explained for other reasons than intake restrictions. Also, fat excess might have contributed to disease burden as continuously reported in the literature.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jcag\/gwab006","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T04:14:31Z","timestamp":1614226471000},"page":"290-295","source":"Crossref","is-referenced-by-count":16,"title":["Nutritional Global Status and Its Impact in Crohn\u2019s Disease"],"prefix":"10.1093","volume":"4","author":[{"given":"Juliana Midori Iqueda","family":"Prieto","sequence":"first","affiliation":[{"name":"Institute of Nutrition, Department of Nutrition, Faculty of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Ribas","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, University of Sao Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Oliveira","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Campinas, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Imbrizi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medical Sciences, State University of Campinas-UNICAMP, Campinas, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00eada","family":"Nishitokukado","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, HC-FMUSP, Laboratory of Experimental Clinical Gastroenterology, LIM 07, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Lucia","family":"Ortiz-Agostinho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, HC-FMUSP, Laboratory of Experimental Clinical Gastroenterology, LIM 07, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Maria","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, HC-FMUSP, Laboratory of Experimental Clinical Gastroenterology, LIM 07, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liania Alves","family":"Luzia","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Department of Nutrition, Faculty of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Helen de Carvalho","family":"Rondo","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Department of Nutrition, Faculty of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Zonetti de Arruda","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, University of Sao Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flair Jos\u00e9","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, University of Sao Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aytan Miranda","family":"Sipahi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Clinical Hospital of the University of S\u00e3o Paulo, University of Sao Paulo, S\u00e3o Paulo, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"issue":"4","key":"2021120508521777700_CIT0001","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejim.2010.04.012","article-title":"Nutritional status in patients with active inflammatory bowel disease: Prevalence of malnutrition and methods for routine nutritional assessment","volume":"21","author":"Mijac","year":"2010","journal-title":"Eur J Intern Med"},{"issue":"12","key":"2021120508521777700_CIT0002","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/ecco-jcc\/jjx102","article-title":"Prevalence of malnutrition and nutritional characteristics of patients with inflammatory bowel disease","volume":"11","author":"Casanova","year":"2017","journal-title":"J Crohns Colitis"},{"issue":"9","key":"2021120508521777700_CIT0003","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.jada.2007.06.011","article-title":"Adequacy of nutritional intake in a Canadian population of patients with Crohn\u2019s disease","volume":"107","author":"Aghdassi","year":"2007","journal-title":"J Am Diet Assoc"},{"issue":"3","key":"2021120508521777700_CIT0004","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/apt.12372","article-title":"Systematic review: Body composition in adults with inflammatory bowel disease","volume":"38","author":"Bryant","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"2021120508521777700_CIT0005","first-page":"i","article-title":"Report of a WHO consultation","volume":"894","author":"Obesity: Preventing and managing the global epidemic","year":"2000","journal-title":"World Health Organ Tech Rep Ser"},{"key":"2021120508521777700_CIT0006"},{"key":"2021120508521777700_CIT0007"},{"key":"2021120508521777700_CIT0008"},{"key":"2021120508521777700_CIT0009","author":"Fisberg","year":"2002"},{"key":"2021120508521777700_CIT0010","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1038\/ejcn.2011.92","article-title":"The MSM program: Web-based statistics package for estimating usual dietary intake using the Multiple Source Method","volume":"65","author":"Harttig","journal-title":"Eur J Clin Nutr"},{"key":"2021120508521777700_CIT0011","doi-asserted-by":"crossref","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for total energy intake in epidemiologic studies","volume":"65","author":"Willett","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"2021120508521777700_CIT0012","author":"WHO."},{"key":"2021120508521777700_CIT0013","volume-title":"Guia alimentar para a popula\u00e7\u00e3o brasileira\/minist\u00e9rio da sa\u00fade, secretaria de aten\u00e7\u00e3o \u00e0 sa\u00fade, departamento de aten\u00e7\u00e3o B\u00e1sica.\u2013 2. ed. \u2013 Bras\u00edlia: minist\u00e9rio da sa\u00fade, 2014. ISBN 978-85-334-2176-9"},{"key":"2021120508521777700_CIT0014","volume-title":"Institute of Medicine (US) Subcommittee on Interpretation and Uses of Dietary Reference Intakes, Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes","year":"2000"},{"key":"2021120508521777700_CIT0015","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc","author":"Institute of Medicine (US) Panel on Micronutrients","year":"2001"},{"issue":"8167","key":"2021120508521777700_CIT0016","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(80)92767-1","article-title":"A simple index of Crohn\u2019s-disease activity","volume":"1","author":"Harvey","year":"1980","journal-title":"Lancet"},{"issue":"4","key":"2021120508521777700_CIT0017","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ajg.2011.44","article-title":"Dietary intake and risk of developing inflammatory bowel disease: A systematic review of the literature","volume":"106","author":"Hou","year":"2011","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"2021120508521777700_CIT0018","first-page":"181","article-title":"Dining with inflammatory bowel disease: A review of the literature on diet in the pathogenesis and management of IBD","volume":"26","author":"Gu","year":"2020","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"2021120508521777700_CIT0019","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/gutjnl-2012-304119","article-title":"Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation","volume":"63","author":"Martinez-Medina","year":"2014","journal-title":"Gut"},{"issue":"5","key":"2021120508521777700_CIT0020","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/gutjnl-2013-305304","article-title":"Long-term intake of dietary fat and risk of ulcerative colitis and Crohn\u2019s disease","volume":"63","author":"Ananthakrishnan","year":"2014","journal-title":"Gut"},{"key":"2021120508521777700_CIT0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humic.2018.01.001","article-title":"Gut microbiota diversity according to dietary habits and geographical provenance","volume":"7\u20138","author":"Senghor","year":"2018","journal-title":"Hum Microbiome J"},{"issue":"10","key":"2021120508521777700_CIT0022","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1007\/s10620-018-5145-x","article-title":"Children with Crohn\u2019s disease frequently consume select food additives","volume":"63","author":"Lee","year":"2018","journal-title":"Dig Dis Sci"},{"issue":"10","key":"2021120508521777700_CIT0023","first-page":"2722","article-title":"Food additive emulsifiers: A review of their role in foods, legislation and classifications, presence in food supply, dietary exposure, and safety assessment","volume":"63","author":"Cox","year":"2020","journal-title":"Nutr Rev"},{"issue":"5","key":"2021120508521777700_CIT0024","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1572-0241.2006.00381.x","article-title":"A population-based case control study of potential risk factors for IBD","volume":"101","author":"Bernstein","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"2021120508521777700_CIT0025","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/j.gastro.2019.03.015","article-title":"A diet low in red and processed meat does not reduce rate of Crohn\u2019s disease flares","volume":"157","author":"Albenberg","year":"2019","journal-title":"Gastroenterology"},{"issue":"3","key":"2021120508521777700_CIT0026","doi-asserted-by":"crossref","first-page":"e024555","DOI":"10.1136\/bmjopen-2018-024555","article-title":"Impact of red meat, processed meat and fibre intake on risk of late-onset chronic inflammatory diseases: Prospective cohort study on lifestyle factors using the Danish \u2018Diet, Cancer and Health\u2019 cohort (PROCID-DCH): Protocol","volume":"9","author":"Rasmussen","year":"2019","journal-title":"BMJ Open"},{"issue":"2","key":"2021120508521777700_CIT0027","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3390\/nu12020372","article-title":"Nutritional aspects in inflammatory bowel diseases","volume":"12","author":"Balestrieri","year":"2020","journal-title":"Nutrients"},{"issue":"11","key":"2021120508521777700_CIT0028","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/1751-2980.12283","article-title":"Vitamin D deficiency in patients with intestinal malabsorption syndromes\u2013think in and outside the gut","volume":"16","author":"Margulies","year":"2015","journal-title":"J Dig Dis"},{"issue":"13","key":"2021120508521777700_CIT0029","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.3748\/wjg.v20.i13.3542","article-title":"Anemia in inflammatory bowel disease: A neglected issue with relevant effects","volume":"20","author":"Guagnozzi","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"35","key":"2021120508521777700_CIT0030","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.3748\/wjg.v22.i35.7868","article-title":"Interaction of obesity and inflammatory bowel disease","volume":"22","author":"Harper","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"2","key":"2021120508521777700_CIT0031","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1590\/s0004-2803.201800000-25","article-title":"Visceral fat is increased in individuals with Crohn\u2019s disease: A comparative analysis with healthy controls","volume":"55","author":"Magro","year":"2018","journal-title":"Arq Gastroenterol"},{"issue":"5","key":"2021120508521777700_CIT0032","doi-asserted-by":"crossref","first-page":"e0195123","DOI":"10.1371\/journal.pone.0195123","article-title":"Obesity and response to anti-tumor necrosis factor-\u03b1 agents in patients with select immune-mediated inflammatory diseases: A systematic review and meta-analysis","volume":"13","author":"Singh","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"2021120508521777700_CIT0033","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn\u2019s disease","volume":"6","author":"Roda","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"2021120508521777700_CIT0034","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1590\/s0004-2803.201700000-37","article-title":"Obesity and Crohn\u2019s disease: What comes first, the egg or the chicken?","volume":"54","author":"Kotze","year":"2017","journal-title":"Arq Gastroenterol"},{"issue":"5","key":"2021120508521777700_CIT0035","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051348","article-title":"High intake of sugar and the balance between pro- and anti-inflammatory gut bacteria","volume":"12","author":"Satokari","year":"2020","journal-title":"Nutrients"}],"container-title":["Journal of the Canadian Association of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcag\/article-pdf\/4\/6\/290\/41504197\/gwab006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcag\/article-pdf\/4\/6\/290\/41504197\/gwab006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T08:52:40Z","timestamp":1638694360000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcag\/article\/4\/6\/290\/6184010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3,23]]},"published-print":{"date-parts":[[2021,12,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jcag\/gwab006","relation":{},"ISSN":["2515-2084","2515-2092"],"issn-type":[{"value":"2515-2084","type":"print"},{"value":"2515-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,3,23]]}}}