{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T20:18:38Z","timestamp":1784405918513,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Actavis Specialty Pharmaceuticals Co."},{"name":"Canadian Society of Intestinal Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Irritable bowel syndrome (IBS) is a chronic, debilitating, functional gastrointestinal disorder with symptoms of abdominal pain, bloating, and altered bowel behaviours of constipation (IBS-C), diarrhea (IBS-D), or a mixture of both (IBS-M). There is limited information published on the impact of symptoms on everyday life in the Canadian population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An online survey was conducted with individuals diagnosed with IBS to capture the severity and frequency of patient-reported symptoms, including impact on productivity, quality of life, healthcare utilization, treatment access, and corresponding symptom relief. Responses from the three subtypes of IBS were categorized to illustrate differences among these.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>There were 2,470 qualified respondents (filtered from 2,981, which included nonspecific IBS). IBS-M was the most common subtype, at 44 percent. Most individuals from all three IBS subtypes reported experiencing moderate to severe abdominal pain (63\u201370 percent) and bloating (59\u201375 percent) over the previous 3 months. Persons living with IBS-C reported severe bloating (32 percent), straining (72 percent), and tenesmus (78 percent) whereas those with IBS-D experienced severe urgency (63 percent) and incontinence (29 percent). Symptoms interfered in daily life, sometimes in 46 percent and often in 23 percent of respondents. Patients reported mood and anxiety disorders as common comorbidities with IBS (mood disorders: 30\u201334 percent; anxiety disorders: 25\u201330 percent).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study focuses on the differences among the IBS subtypes. IBS impacts productivity and healthcare utilization, which requires further investigation on approaches to improve treatment. The frequency and severity of symptoms in IBS are high and only a few respondents reported that their symptoms are under control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jcag\/gwad028","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T21:18:24Z","timestamp":1696022304000},"page":"219-228","source":"Crossref","is-referenced-by-count":12,"title":["Irritable Bowel Syndrome Patient Experience: A Survey of Patient-Reported Symptoms by Irritable Bowel Syndrome Subtype and Impact on Quality of Life"],"prefix":"10.1093","volume":"6","author":[{"given":"Ganive","family":"Bhinder","sequence":"first","affiliation":[{"name":"Canadian Society of Intestinal Research , Vancouver, BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier M","family":"Meza-Cardona","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Espa\u00f1ol de Mexico , Mexico City , Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Low","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia , Vancouver, BC , Canada"},{"name":"Gastrointestinal Society , Vancouver, BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Aumais","sequence":"additional","affiliation":[{"name":"D\u00e9partmente de m\u00e9dicine, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al , QC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail P","family":"Attara","sequence":"additional","affiliation":[{"name":"Canadian Society of Intestinal Research , Vancouver, BC , Canada"},{"name":"Gastrointestinal Society , Vancouver, BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R","family":"Gray","sequence":"additional","affiliation":[{"name":"Canadian Society of Intestinal Research , Vancouver, BC , Canada"},{"name":"Gastrointestinal Society , Vancouver, BC , Canada"},{"name":"Division of Gastroenterology, University of British Columbia , Vancouver, BC , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"2023121523484401400_CIT0001","first-page":"712","article-title":"\u201cGlobal Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-Analysis.\u201d","volume-title":"Clinical Gastroenterology and Hepatology","author":"Lovell","year":"2012"},{"issue":"2","key":"2023121523484401400_CIT0002","first-page":"158","article-title":"\u201cEpidemiology of Irritable Bowel Syndrome.\u201d","volume":"28","author":"Endo","year":"2015","journal-title":"Annals of Gastroenterology"},{"key":"2023121523484401400_CIT0003","first-page":"71","article-title":"\u201cThe Epidemiology of Irritable Bowel Syndrome.\u201d","volume-title":"Clinical Epidemiology","author":"Canavan,","year":"2014"},{"issue":"5","key":"2023121523484401400_CIT0004","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2019.12.021","article-title":"\u201cPrevalence of Rome IV Functional Bowel Disorders Among Adults in the United States, Canada, and the United Kingdom.\u201d","volume":"158","author":"Olafur,","year":"2020","journal-title":"Gastroenterology"},{"issue":"2","key":"2023121523484401400_CIT0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000505287","article-title":"\u201cIrritable Bowel Syndrome Subtypes: New Names for Old Medical Conditions.\u201d","volume":"38","author":"Grad","year":"2020","journal-title":"Digestive Diseases"},{"issue":"2","key":"2023121523484401400_CIT0006","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5056\/jnm16214","article-title":"\u201cWhat is New in Rome IV.\u201d","volume":"23","author":"Schmulson","year":"2017","journal-title":"Journal of Neurogastroenterology and Motility"},{"key":"2023121523484401400_CIT0007","first-page":"345","article-title":"\u201cThe Role of Inflammation in Irritable Bowel Syndrome (IBS).\u201d","volume-title":"Journal of Inflammation Research","author":"Ng","year":"2018"},{"key":"2023121523484401400_CIT0008","first-page":"e0139389","article-title":"\u201cChange in Quality of Life for Patients with Irritable Bowel Syndrome following Referral to a Gastroenterologist: A Cohort Study.\u201d","volume-title":"PLoS One","author":"Canavan","year":"2015"},{"key":"2023121523484401400_CIT0009","first-page":"12","article-title":"\u201cEvaluation of Health Related Quality of Life in Irritable Bowel Syndrome Patients.\u201d","volume-title":"Health and Quality of Life Outcomes","author":"Jamali","year":"2012"},{"key":"2023121523484401400_CIT0010","first-page":"208","article-title":"\u201cEvaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) Questionnaire in Diarrheal-Predominant Irritable Bowel Syndrome Patients.\u201d","volume-title":"Health and Quality of Life Outcomes","author":"Andrae","year":"2013"},{"key":"2023121523484401400_CIT0011","first-page":"892","article-title":"\u201cComparison of Symptoms, Healthcare Utilization, and Treatment in Diagnosed and Undiagnosed Individuals With Diarrhea-Predominant Irritable Bowel Syndrome.\u201d","volume-title":"American Journal of Gastroenterology","author":"Sayuk","year":"2017"},{"key":"2023121523484401400_CIT0012","first-page":"37","article-title":"\u201cDiagnosis, Comorbidities, and Management of Irritable Bowel Syndrome in Patients in a Large Health Maintenance Organization.\u201d","volume-title":"Clinical Gastroenterology and Hepatology","author":"Ladabaum","year":"2012"},{"key":"2023121523484401400_CIT0013","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"\u201cBowel Disorders.\u201d","volume":"150","author":"Lacy","year":"2016","journal-title":"Gastroenterology"},{"key":"2023121523484401400_CIT0014","first-page":"6","article-title":"\u201cCanadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS).\u201d","volume-title":"Journal of the Canadian Association of Gastroenterology","author":"Moayyedi","year":"2019"},{"key":"2023121523484401400_CIT0015","first-page":"2566","article-title":"\u201cIrritable Bowel Syndrome.\u201d","volume-title":"New England Journal of Medicine","author":"Ford","year":"2017"},{"key":"2023121523484401400_CIT0016","first-page":"127","article-title":"\u201cIrritable Bowel Syndrome: Diagnostic Approaches in Clinical Practice.\u201d","volume-title":"Clinical and Experimental Gastroenterology","author":"Burbige","year":"2010"},{"key":"2023121523484401400_CIT0017","first-page":"1327","article-title":"\u201cImpact of Irritable Bowel Syndrome on Personal Relationships and Working Practice.\u201d","volume-title":"European Journal of Gastroenterology and Hepatology","author":"Silk","year":"2001"},{"key":"2023121523484401400_CIT0018","first-page":"S17","article-title":"\u201cImpairment in Work Productivity and Health-Related Quality of Life in Patients with IBS.\u201d","volume":"11","author":"Dean","year":"2005","journal-title":"The American Journal of Managed Care"},{"key":"2023121523484401400_CIT0019","first-page":"113","article-title":"\u201cGastrointestinal Symptoms\u2014An Illness Burden That Affects Daily Work in Patients with IBS.\u201d","volume-title":"Health and Quality of Life Outcomes","author":"Faresj\u00f6","year":"2019"},{"key":"2023121523484401400_CIT0020","first-page":"349","article-title":"\u201cThe Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis.\u201d","volume-title":"Journal of Neurogastroenterology and Motility","author":"Lee","year":"2017"},{"key":"2023121523484401400_CIT0021","first-page":"655","article-title":"\u201cIrritable Bowel Syndrome Epidemiology, Pathophysiology, Diagnosis, and Treatment.\u201d","volume-title":"Primary Care","author":"Defrees","year":"2017"},{"key":"2023121523484401400_CIT0022","first-page":"67","article-title":"\u201cA Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome.\u201d","volume-title":"Gastroenterology","author":"Halmos","year":"2014"},{"issue":"3","key":"2023121523484401400_CIT0023","first-page":"CD003460","article-title":"\u201cBulking Agents, Antispasmodics and Antidepressants for the Treatment of Irritable Bowel Syndrome.\u201d","volume":"2013","author":"Ruepert","year":"2011","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"2023121523484401400_CIT0024","first-page":"1253","article-title":"\u201cMeta-Analysis: The Treatment of Irritable Bowel Syndrome.\u201d","volume-title":"Alimentary Pharmacology and Therapeutics","author":"Lesbros-Pantoflickova","year":"2004"}],"container-title":["Journal of the Canadian Association of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcag\/article-pdf\/6\/6\/219\/54492914\/gwad028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcag\/article-pdf\/6\/6\/219\/54492914\/gwad028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:17Z","timestamp":1702684817000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcag\/article\/6\/6\/219\/7286544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,9,29]]},"published-print":{"date-parts":[[2023,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/jcag\/gwad028","relation":{},"ISSN":["2515-2084","2515-2092"],"issn-type":[{"value":"2515-2084","type":"print"},{"value":"2515-2092","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,9,29]]}}}