{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:40:11Z","timestamp":1784882411428,"version":"3.55.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and Aims<\/jats:title>\n                  <jats:p>Endoscopic treatment is a definitive and cost-effective management strategy for early neoplasia in Barrett\u2019s oesophagus (BE). However, little is known of its impact on quality of life (QoL). This study reports outcomes of endoscopic eradication treatment (EET), focusing on QoL and costs in a Canadian tertiary referral centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study using a prospectively maintained clinical database captured validated QoL metrics during and at the end of EET, risk factors for BE, treatment response, complications, costs, and follow-up response of all treated Barrett patients in Calgary and Southern Alberta, Canada.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 147 BE patients were treated from 2013 to 2021. All patients showed significant improvement in almost all QoL parameters except depression. There was significant improvement in 7 of the 8 QoL metrics in those who achieved complete eradication of intestinal metaplasia (CEIM). EET was successful in achieving complete eradication of dysplasia (CED) and CEIM in 93.4% and 74.3% of patients, respectively, with a median of 3 radio frequency ablation treatments. Longer circumferential segments of BE (Cx) predicted a lower likelihood of achieving CEIM. The average total cost to achieve CED and CEIM were $10 414.58 and $9347.93CAD, respectively (compared to oesophagectomy estimated at $58 332.30 CAD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This Canadian cohort reports significant post-treatment improvement in QoL parameters in patients treated to CEIM or CED over an 8-year period. EET for BE eradication is cost-effective compared to oesophagectomy. There was a low rate of complications and recurrence post-CEIM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jcag\/gwae018","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T22:22:56Z","timestamp":1719440576000},"page":"368-375","source":"Crossref","is-referenced-by-count":1,"title":["Quality of life, clinical outcomes and cost utilization of endoscopic therapy in patients with Barrett\u2019s esophagus and early esophageal cancer\u2014an 8-year Canadian experience"],"prefix":"10.1093","volume":"7","author":[{"given":"Joel","family":"David","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Calgary, Cumming School of Medicine , 3330 Hospital Dr NW. Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Woo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Calgary, Cumming School of Medicine , 3330 Hospital Dr NW. Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3342-3531","authenticated-orcid":false,"given":"Stephen","family":"Congly","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Calgary, Cumming School of Medicine , 3330 Hospital Dr NW. Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher N","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Calgary, Cumming School of Medicine , 3330 Hospital Dr NW. Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thurarshen","family":"Jeyalingam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Toronto , 27 King\u2019s College Cir, Toronto, ON M5S 1A1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Belletrutti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Calgary, Cumming School of Medicine , 3330 Hospital Dr NW. Calgary, AB T2N 4N1 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milli","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Calgary, Cumming School of Medicine , 3330 Hospital Dr NW. 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