{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:43:30Z","timestamp":1760798610006,"version":"3.37.3"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent work has illuminated the bizarre sex chromosomal system of the mandarin vole, Lasiopodomys mandarinus. The ancestral sex chromosomes have been replaced by 4 neo-sex chromosomes. These sex chromosomes show non-Mendelian inheritance and epistatic sex determination, as well as unaccounted-for karyotype frequencies. I suggest a model to account for the complex observed inheritance patterns. The proposed model combines putative adaptations previously observed in rodents, including feminizing X chromosomes and Y-biased spermatogenesis, with a novel proposed mechanism of genomic imprinting of X-linked genes during oogenesis in XY females. Alternative possibilities are also discussed. The proposed scenario provides a relatively simple and testable model for the function and origins of a remarkably complex mammalian sex chromosomal system.<\/jats:p>","DOI":"10.1093\/jhered\/esab020","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T03:09:59Z","timestamp":1619060999000},"page":"328-334","source":"Crossref","is-referenced-by-count":8,"title":["On the Form and Origins of the Bizarre Sex Chromosomal System of the Mandarin Vole"],"prefix":"10.1093","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6459","authenticated-orcid":false,"given":"Scott William","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Biology, San Francisco State University , San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"2023030808365682000_","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000318012","article-title":"Comparative analysis by chromosome painting of the sex chromosomes in arvicolid rodents","volume":"132","author":"Acosta","year":"2011","journal-title":"Cytogenet Genome Res"},{"volume-title":"Evolution of sex determining mechanisms","year":"1983","author":"Bull","key":"2023030808365682000_"},{"key":"2023030808365682000_","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/hdy.1981.97","article-title":"The evolution of XY females in mammals","volume":"47","author":"Bull","year":"1981","journal-title":"Heredity (Edinb)"},{"volume-title":"Genes in conflict: the biology of selfish genetic elements","year":"2009","author":"Burt","key":"2023030808365682000_"},{"key":"2023030808365682000_","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1365-2540.2001.00803.x","article-title":"A model of the evolution of the unusual sex chromosome system of Microtus oregoni","volume":"86","author":"Charlesworth","year":"2001","journal-title":"Heredity (Edinb)"},{"key":"2023030808365682000_","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00335-007-9076-7","article-title":"Sex determination of Microtus mandarinus mandarinus is independent of Sry gene","volume":"19","author":"Chen","year":"2008","journal-title":"Mamm Genome"},{"key":"2023030808365682000_","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/hdy.1987.146","article-title":"Meiotic drive in the sex chromosome system of the varying lemming, Dicrostonyx torquatus Pall.(Rodentia, Microtinae)","volume":"59","author":"Gileva","year":"1987","journal-title":"Heredity"},{"key":"2023030808365682000_","doi-asserted-by":"crossref","first-page":"e0167653","DOI":"10.1371\/journal.pone.0167653","article-title":"Rapid karyotype evolution in Lasiopodomys involved at least two autosome - 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