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Developmental dysplasia of the hip (DDH) and femoroacetabular impingement (FAI) represent key pathologies, resulting from insufficient or excessive femoral head coverage, respectively. These abnormalities alter hip biomechanics, leading to structural damage, pain, and accelerated joint degeneration. Advances in genetic research have illuminated the interplay between genetics and mechanical loading in shaping hip morphology. Genes associated with osteoarthritis, DDH, and FAI include COL1A1, MMP13, and IL-6. Genes associated with FAI and osteoarthritis include ADAMTS4. Genes associated with DDH and osteoarthritis include FRZB, CX3CR1, ASPN, DKK1, PDRG1, GDF5, UQCC1, and TGF-\u03b21. The mechanisms linking morphological derangements to symptomatic osteoarthritis remain incompletely understood. Multimodal approaches integrating imaging, biomechanics, and genetics may uncover distinct disease subtypes, enabling personalized interventions. Early detection of MHAs is critical in preventing early-onset osteoarthritis. Incorporating advanced imaging techniques, such as statistical shape modelling, can enhance the understanding of complex 3D hip morphologies and their progression to osteoarthritis. Future research should explore the genetic underpinnings of other morphologic hip conditions, including Slipped Capital Femoral Epiphysis and Legg\u2013Calv\u00e9\u2013Perthes disease, to refine preventive and therapeutic strategies. A comprehensive approach combining genetics, imaging, and clinical insights holds promise for mitigating the lifelong impact of MHAs.<\/jats:p>","DOI":"10.1093\/jhps\/hnaf020","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T11:28:24Z","timestamp":1744975704000},"page":"202-216","source":"Crossref","is-referenced-by-count":5,"title":["Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping review"],"prefix":"10.1093","volume":"12","author":[{"given":"Lainey G","family":"Bukowiec","sequence":"first","affiliation":[{"name":"Mayo Clinic Department of Orthopedic Surgery , 200 First St, Rochester, MN 55905,","place":["United States"]},{"name":"Mayo Clinic Orthopedic Surgery Artificial Intelligence Lab , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S","family":"Kaji","sequence":"additional","affiliation":[{"name":"Mayo Clinic Orthopedic Surgery Artificial Intelligence Lab , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A","family":"Koch","sequence":"additional","affiliation":[{"name":"Mayo Clinic Orthopedic Surgery Artificial Intelligence Lab , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Saniei","sequence":"additional","affiliation":[{"name":"Mayo Clinic Orthopedic Surgery Artificial Intelligence Lab , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel M","family":"Girod-Hoffmann","sequence":"additional","affiliation":[{"name":"Mayo Clinic Orthopedic Surgery Artificial Intelligence Lab , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P","family":"Sinnwell","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Quantitative Health Sciences , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-7567","authenticated-orcid":false,"given":"Cody C","family":"Wyles","sequence":"additional","affiliation":[{"name":"Mayo Clinic Department of Orthopedic Surgery , 200 First St, Rochester, MN 55905,","place":["United States"]},{"name":"Mayo Clinic Orthopedic Surgery Artificial Intelligence Lab , 200 First St, Rochester, MN 55905,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"2025092505063612000_R1","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1007\/s11999-007-0060-z","article-title":"The etiology of osteoarthritis of the hip: an integrated mechanical concept","volume":"466","author":"Ganz","year":"2008","journal-title":"Clin Orthop Relat Res"},{"key":"2025092505063612000_R2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1097\/00003086-198612000-00004","article-title":"Etiology of osteoarthritis of the hip","volume":"213","author":"Harris","year":"1986","journal-title":"Clin Orthop Relat Res"},{"key":"2025092505063612000_R3","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1302\/0301-620X.87B7.15203","article-title":"Hip morphology influences the pattern of damage to the acetabular cartilage: femoroacetabular impingement as a cause of early osteoarthritis of the hip","volume":"87-B","author":"Beck","year":"2005","journal-title":"J Bone Joint Surg Br"},{"key":"2025092505063612000_R4","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/art.39929","article-title":"Cam deformity and acetabular dysplasia as risk factors for hip osteoarthritis","volume":"69","author":"Saberi Hosnijeh","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2025092505063612000_R5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2106\/JBJS.J.01734","article-title":"Radiographic structural abnormalities associated with premature, natural hip-joint failure","volume":"93","author":"Clohisy","year":"2011","journal-title":"J Bone Joint Surg Am"},{"key":"2025092505063612000_R6","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/j.joca.2014.06.038","article-title":"Subclinical deformities of the hip are significant predictors of radiographic osteoarthritis and joint replacement in women. 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