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One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molecular mechanisms of action that underly those bioactivities. Particular emphasis is placed on RiPP\/target interactions for which there is structural information. This detailed mechanism of action work is critical toward the development of RiPPs as therapeutics and can also be used to prioritize hits in RiPP genome mining studies.<\/jats:p>","DOI":"10.1093\/jimb\/kuab005","type":"journal-article","created":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T20:19:03Z","timestamp":1611519543000},"source":"Crossref","is-referenced-by-count":100,"title":["Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs)"],"prefix":"10.1093","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-6056","authenticated-orcid":false,"given":"Li","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7212-0296","authenticated-orcid":false,"given":"Truc","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5066-9691","authenticated-orcid":false,"given":"A James","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA"},{"name":"Department of Chemistry, Princeton University, Princeton, NJ 08544, USA"},{"name":"Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,1,27]]},"reference":[{"key":"2022051714395297000_bib1","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/anie.198510511","article-title":"Elucidation of the structure of epidermin, a ribosomally synthesized, tetracyclic heterodetic polypeptide antibiotic","volume":"24","author":"Allgaier","year":"1985","journal-title":"Angewandte Chemie (International Ed. in English)"},{"key":"2022051714395297000_bib2","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1007\/s00253-016-7343-9","article-title":"Bacteriocins of lactic acid bacteria: Extending the family","volume":"100","author":"Alvarez-Sieiro","year":"2016","journal-title":"Applied Microbiology and Biotechnology"},{"key":"2022051714395297000_bib3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.biophys.36.040306.132643","article-title":"Bilayer thickness and membrane protein function: An energetic perspective","volume":"36","author":"Andersen","year":"2007","journal-title":"Annual Review of Biophysics and Biomolecular Structure"},{"key":"2022051714395297000_bib4","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1128\/AEM.64.6.2269-2272.1998","article-title":"Antagonistic activity of Lactobacillus plantarum C11: Two new two- peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A","volume":"64","author":"Anderssen","year":"1998","journal-title":"Applied and Environmental Microbiology"},{"key":"2022051714395297000_bib5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7164\/antibiotics.29.511","article-title":"Gardimycin, a new antibiotic from Actionoplanes. 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