{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:52:41Z","timestamp":1791967961673,"version":"4.3.4"},"reference-count":81,"publisher":"Oxford University Press (OUP)","issue":"1-2","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0905100"],"award-info":[{"award-number":["2019YFA0905100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21878220"],"award-info":[{"award-number":["21878220"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Forskolin, a class of labdane-type diterpenoid, has significant medicinal value in anticancer, antiasthmatic, antihypertensive, and heart-strengthening treatments. The main source of natural forskolin is its extraction from the cork tissue of the root of Coleus forskohlii. However, conventional modes of extraction pose several challenges. In recent years, the construction of microbial cell factories to produce medicinal natural products via synthetic biological methods has effectively solved the current problems and is a research hotspot in this field. This review summarizes the recent progress in the heterologous synthesis of forskolin via synthetic biological technology, analyzes the current challenges, and proposes corresponding strategies.<\/jats:p>","DOI":"10.1093\/jimb\/kuab009","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T03:37:13Z","timestamp":1612409833000},"source":"Crossref","is-referenced-by-count":16,"title":["Progress in heterologous biosynthesis of forskolin"],"prefix":"10.1093","volume":"48","author":[{"given":"Haiyan","family":"Ju","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyu","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, P. R. China"},{"name":"Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education, Tianjin 300350, P. R. China"},{"name":"SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300350, P. R. 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