{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:48:19Z","timestamp":1781070499175,"version":"3.54.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:00:00Z","timestamp":1758758400000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007173","name":"Bio-oriented Technology Research Advancement Institution","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006370","name":"Small Business Innovation Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Terephthalic acid, a key precursor for polyester production, is traditionally derived from fossil resources, contributing to global warming. Although numerous studies have explored the production of terephthalic acid from biomass polysaccharides, energy-intensive chemical processes are predominantly employed. In this study, we have developed a biochemical process to produce bio-based terephthalic acid from lignocellulosic biomass for reducing CO2 emissions. Among the tested six underutilized lignocellulosic biomasses, hardwood, with high cellulose contents of 52.8%, was subjected to alkaline pretreatment (165\u2009\u00b0C for 2.5\u00a0hr) to eliminate lignin, and the resulting water-insoluble fraction was hydrolyzed by cellulases to yield monosaccharides. These monosaccharides were then biochemically transformed into terephthalic acid via p-tolualdehyde using two microorganisms, Phlebia sp. (a p-tolualdehyde-producing strain) and Comamonas testosteroni DSM6577. Comamonas testosteroni DSM6577 was used to oxidize the side chains of p-tolualdehyde into carboxylic acid to obtain terephthalic acid. This report describes the successful production of small amounts of bio-based terephthalic acid from lignocellulosic biomass.<\/jats:p>\n               <jats:p>One-Sentence Summary: This paper shows that terephthalic acid, a key precursor for polyester production, can be produced from lignocellulosic biomass by microbial fermentation, which would contribute to reduce CO2 emission compared with other previous processes.<\/jats:p>","DOI":"10.1093\/jimb\/kuaf030","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:55:50Z","timestamp":1758812150000},"source":"Crossref","is-referenced-by-count":1,"title":["Biochemical production of bio-based terephthalic acid from lignocellulosic biomass for CO2 emission reduction"],"prefix":"10.1093","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-870X","authenticated-orcid":false,"given":"Seiji","family":"Nakagame","sequence":"first","affiliation":[{"name":"Kanagawa Institute of Technology 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