{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:19:42Z","timestamp":1790961582991,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15DK127440"],"award-info":[{"award-number":["R15DK127440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity is associated with comorbidities including type 2 diabetes, chronic nonhealing wounds, and psoriasis. Normally, skin homeostasis and repair is regulated through the production of cytokines and growth factors derived from skin-resident cells including epidermal \u03b3\u03b4 T cells. However, epidermal \u03b3\u03b4 T cells exhibit reduced proliferation and defective growth factor and cytokine production during obesity and type 2 diabetes. One of the genes modulated in epidermal \u03b3\u03b4 T cells during obesity and type 2 diabetes is CCR6, which is the receptor for CCL20. CCL20 is elevated in the skin during obesity and type 2 diabetes. Here, we identify a subset of murine epidermal \u03b3\u03b4 T cells that express CCR6 upon activation, both in vitro and in vivo. We show that CCL20 stimulates epidermal \u03b3\u03b4 T cells to produce interleukin (IL)-17, indicating that CCR6 regulates the IL-17 axis in epidermal \u03b3\u03b4 T cells. In murine models of wound repair and psoriasis, these epidermal \u03b3\u03b4 T cells upregulate CCR6 and produce IL-17, with obesity amplifying this response during wound repair but having less effect during psoriasis. These findings have novel implications for the regulation of a specific population of IL-17\u2013producing epidermal \u03b3\u03b4 T cells during skin damage and inflammation.<\/jats:p>","DOI":"10.1093\/jimmun\/vkae011","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T09:58:46Z","timestamp":1737626326000},"page":"153-166","source":"Crossref","is-referenced-by-count":9,"title":["Impact of obesity on the CCR6-CCL20 axis in epidermal \u03b3\u03b4 T cells and IL-17A production in murine wound healing and psoriasis"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7266-8136","authenticated-orcid":false,"given":"William","family":"Lawler","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9227-9163","authenticated-orcid":false,"given":"Cristian R","family":"Alvizo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-4677","authenticated-orcid":false,"given":"Antolette","family":"Kasler","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savannah","family":"Bshara-Corson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-4066","authenticated-orcid":false,"given":"Julie M","family":"Jameson","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State University San Marcos , San Marcos, CA,","place":["United 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