{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:03:21Z","timestamp":1781348601087,"version":"3.54.1"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"SinoMab BioScience Limited"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Autoimmune disease refers to a condition when the immune system anomalously attacks its own body and healthy cells. Although the exact causes of autoimmune diseases are unknown, it is recognized that excessive or aberrant cytokine responses contribute significantly to the development of autoimmunity. Among them, the common gamma c chain (\u03b3c) cytokines driven signaling cascade plays an indispensable role in driving pathogenic immune responses in patients with autoimmune diseases. Thus, we hypothesize that the development of an antibody targeting \u03b3c receptor could serve as a potential approach for treating autoimmune diseases and fulfil the unmet medical needs in this area. Here, we demonstrate that a humanized anti-\u03b3c antibody, hC2, could show high binding affinity to the human \u03b3c receptor and suppress 6 \u03b3c cytokines (interleukin [IL]-2, IL-4, IL-7, IL-9, IL-15 and IL-21)-driven STAT phosphorylation, leading to inhibition of autoimmunity and activation in B, T, and natural killer cell lines. Similar inhibitory effects were observed in the human peripheral blood mononuclear cell culture. Moreover, administration of hC2 could reduce expansion and tissue infiltration of T helper and cytotoxic T cells, leading to attenuation of damages to skin, liver, and kidney in the humanized xenograft mouse model. The current study demonstrates the potential of \u03b3c blockades for the treatment of T cell\u2013mediated autoimmune diseases and chronic graft-versus-host disease. Anti-\u03b3c antibody hC2 might offer a more efficacious therapy compared with antibodies targeting a single \u03b3c cytokine and safer therapy than JAK inhibitors to fulfill the unmet medical needs in the autoimmune diseases in the future.<\/jats:p>","DOI":"10.1093\/jimmun\/vkae020","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:43:26Z","timestamp":1741776206000},"page":"606-623","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of a new anti-\u03b3c antibody in clinical development for the treatment of autoimmune diseases"],"prefix":"10.1093","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-2624","authenticated-orcid":false,"given":"Chin Wai","family":"Hui","sequence":"first","affiliation":[{"name":"SinoMab BioScience Limited, Pak Shek Kok , New Territories, Hong Kong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7031-4413","authenticated-orcid":false,"given":"Wai Chung","family":"Wu","sequence":"additional","affiliation":[{"name":"SinoMab BioScience Limited, Pak Shek Kok , New Territories, Hong Kong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak Keung","family":"Tong","sequence":"additional","affiliation":[{"name":"SinoMab BioScience Limited, Pak Shek Kok , New Territories, Hong Kong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Shiu","sequence":"additional","affiliation":[{"name":"SinoMab BioScience Limited, Pak Shek Kok , New Territories, Hong Kong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoi Lam","family":"Ng","sequence":"additional","affiliation":[{"name":"SinoMab BioScience Limited, Pak Shek Kok , New Territories, Hong 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